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Results: 1 to 20 of 101

1.

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Navia-Paldanius D, Aaltonen N, Lehtonen M, Savinainen JR, Taschler U, Radner FP, Zimmermann R, Laitinen JT.

Eur J Pharm Sci. 2015 Sep 18;77:180-8. doi: 10.1016/j.ejps.2015.06.005. Epub 2015 Jun 9.

PMID:
26070239
2.

Loratadine analogues as MAGL inhibitors.

Patel JZ, Ahenkorah S, Vaara M, Staszewski M, Adams Y, Laitinen T, Navia-Paldanius D, Parkkari T, Savinainen JR, Walczyński K, Laitinen JT, Nevalainen TJ.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42. doi: 10.1016/j.bmcl.2015.02.037. Epub 2015 Feb 24.

PMID:
25752982
3.

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T.

ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec 11.

PMID:
25504894
4.

Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities.

Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1226-32. doi: 10.1152/ajpheart.00315.2013. Epub 2014 Aug 22.

PMID:
25320333
5.

Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).

Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT.

PLoS One. 2014 Oct 7;9(10):e109869. doi: 10.1371/journal.pone.0109869. eCollection 2014.

6.

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ.

Bioorg Med Chem. 2014 Dec 1;22(23):6694-705. doi: 10.1016/j.bmc.2014.09.012. Epub 2014 Sep 16.

PMID:
25282655
7.

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT.

Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19.

PMID:
25140003
8.

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, Vaara M, Lehtonen M, Alakurtti S, Yli-Kauhaluoma J, Nevalainen T, Savinainen JR, Laitinen JT.

PLoS One. 2014 May 30;9(5):e98286. doi: 10.1371/journal.pone.0098286. eCollection 2014.

9.
10.

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR.

Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24.

11.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T.

J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22.

PMID:
24083878
12.

Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice.

Aaltonen N, Riera Ribas C, Lehtonen M, Savinainen JR, Laitinen JT.

Eur J Pharm Sci. 2014 Jan 23;51:87-95. doi: 10.1016/j.ejps.2013.08.035. Epub 2013 Sep 3.

PMID:
24012970
13.

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT.

Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012.

14.

Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice.

Kärkkäine E, Tanila H, Laitinen JT.

CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1038-44.

PMID:
23244427
15.

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).

Navia-Paldanius D, Savinainen JR, Laitinen JT.

J Lipid Res. 2012 Nov;53(11):2413-24. doi: 10.1194/jlr.M030411. Epub 2012 Sep 11.

16.

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation.

Aaltonen N, Lehtonen M, Varonen K, Goterris GA, Laitinen JT.

BMC Pharmacol. 2012 Jun 11;12:7. doi: 10.1186/1471-2210-12-7.

17.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors.

Savinainen JR, Saario SM, Laitinen JT.

Acta Physiol (Oxf). 2012 Feb;204(2):267-76. doi: 10.1111/j.1748-1716.2011.02280.x. Epub 2011 Apr 22. Review. Erratum in: Acta Physiol (Oxf). 2012 Mar;204(3):460.

18.

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy.

Korpisalo P, Hytönen JP, Laitinen JT, Laidinen S, Parviainen H, Karvinen H, Siponen J, Marjomäki V, Vajanto I, Rissanen TT, Ylä-Herttuala S.

Eur Heart J. 2011 Jul;32(13):1664-72. doi: 10.1093/eurheartj/ehq433. Epub 2010 Dec 7.

19.

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry.

Aaltonen N, Laitinen JT, Lehtonen M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 1;878(15-16):1145-52. doi: 10.1016/j.jchromb.2010.03.030. Epub 2010 Mar 20.

PMID:
20381434
20.

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique.

Savinainen JR, Yoshino M, Minkkilä A, Nevalainen T, Laitinen JT.

Anal Biochem. 2010 Apr 1;399(1):132-4. doi: 10.1016/j.ab.2009.12.009. Epub 2009 Dec 11.

PMID:
20005861
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