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Results: 1 to 20 of 98

1.

Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities.

Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1226-32. doi: 10.1152/ajpheart.00315.2013. Epub 2014 Aug 22.

PMID:
25320333
[PubMed - in process]
2.

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A).

Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT.

PLoS One. 2014 Oct 7;9(10):e109869. doi: 10.1371/journal.pone.0109869. eCollection 2014.

PMID:
25290914
[PubMed - in process]
Free PMC Article
3.

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ.

Bioorg Med Chem. 2014 Sep 16. pii: S0968-0896(14)00648-8. doi: 10.1016/j.bmc.2014.09.012. [Epub ahead of print]

PMID:
25282655
[PubMed - as supplied by publisher]
4.

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT.

Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19.

PMID:
25140003
[PubMed - in process]
5.

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, Vaara M, Lehtonen M, Alakurtti S, Yli-Kauhaluoma J, Nevalainen T, Savinainen JR, Laitinen JT.

PLoS One. 2014 May 30;9(5):e98286. doi: 10.1371/journal.pone.0098286. eCollection 2014.

PMID:
24879289
[PubMed - in process]
Free PMC Article
6.

Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.

Jokela TA, Kärnä R, Makkonen KM, Laitinen JT, Tammi RH, Tammi MI.

J Biol Chem. 2014 Jun 27;289(26):18569-81. doi: 10.1074/jbc.M114.551804. Epub 2014 May 20.

PMID:
24847057
[PubMed - indexed for MEDLINE]
7.

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR.

Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24.

PMID:
24368842
[PubMed - indexed for MEDLINE]
8.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T.

J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22.

PMID:
24083878
[PubMed - indexed for MEDLINE]
9.

Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice.

Aaltonen N, Riera Ribas C, Lehtonen M, Savinainen JR, Laitinen JT.

Eur J Pharm Sci. 2014 Jan 23;51:87-95. doi: 10.1016/j.ejps.2013.08.035. Epub 2013 Sep 3.

PMID:
24012970
[PubMed - indexed for MEDLINE]
10.

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT.

Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012.

PMID:
23521796
[PubMed - indexed for MEDLINE]
Free Article
11.

Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice.

Kärkkäine E, Tanila H, Laitinen JT.

CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1038-44.

PMID:
23244427
[PubMed - indexed for MEDLINE]
12.

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).

Navia-Paldanius D, Savinainen JR, Laitinen JT.

J Lipid Res. 2012 Nov;53(11):2413-24. doi: 10.1194/jlr.M030411. Epub 2012 Sep 11.

PMID:
22969151
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation.

Aaltonen N, Lehtonen M, Varonen K, Goterris GA, Laitinen JT.

BMC Pharmacol. 2012 Jun 11;12:7. doi: 10.1186/1471-2210-12-7.

PMID:
22686545
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors.

Savinainen JR, Saario SM, Laitinen JT.

Acta Physiol (Oxf). 2012 Feb;204(2):267-76. doi: 10.1111/j.1748-1716.2011.02280.x. Epub 2011 Apr 22. Review. Erratum in: Acta Physiol (Oxf). 2012 Mar;204(3):460.

PMID:
21418147
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy.

Korpisalo P, Hytönen JP, Laitinen JT, Laidinen S, Parviainen H, Karvinen H, Siponen J, Marjomäki V, Vajanto I, Rissanen TT, Ylä-Herttuala S.

Eur Heart J. 2011 Jul;32(13):1664-72. doi: 10.1093/eurheartj/ehq433. Epub 2010 Dec 7.

PMID:
21138938
[PubMed - indexed for MEDLINE]
Free Article
16.

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry.

Aaltonen N, Laitinen JT, Lehtonen M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 1;878(15-16):1145-52. doi: 10.1016/j.jchromb.2010.03.030. Epub 2010 Mar 20.

PMID:
20381434
[PubMed - indexed for MEDLINE]
17.

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique.

Savinainen JR, Yoshino M, Minkkilä A, Nevalainen T, Laitinen JT.

Anal Biochem. 2010 Apr 1;399(1):132-4. doi: 10.1016/j.ab.2009.12.009. Epub 2009 Dec 11.

PMID:
20005861
[PubMed - indexed for MEDLINE]
18.

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.

Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM.

ChemMedChem. 2009 Aug;4(8):1253-9. doi: 10.1002/cmdc.200900137. No abstract available.

PMID:
19472270
[PubMed - indexed for MEDLINE]
19.

PACAP27 regulates ciliary function in primary cultures of rat brain ependymal cells.

Mönkkönen KS, Hirst RA, Laitinen JT, O'Callaghan C.

Neuropeptides. 2008 Oct-Dec;42(5-6):633-40. doi: 10.1016/j.npep.2008.09.006. Epub 2008 Nov 4. Erratum in: Neuropeptides. 2009 Apr;43(2):177. Mnkkonen, K S [corrected to Mönkkönen, K S].

PMID:
18986701
[PubMed - indexed for MEDLINE]
20.

Neuroanatomical mapping of juvenile rat brain regions with prominent basal signal in [(35)S]GTPgammaS autoradiography.

Aaltonen N, Palomäki VA, Lecklin A, Laitinen JT.

J Chem Neuroanat. 2008 Mar;35(2):233-41. doi: 10.1016/j.jchemneu.2007.12.003. Epub 2007 Dec 23.

PMID:
18242056
[PubMed - indexed for MEDLINE]

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