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Items: 1 to 20 of 22

1.

Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action.

Feinstein HE, Benbow SJ, LaPointe NE, Patel N, Ramachandran S, Do TD, Gaylord MR, Huskey NE, Dressler N, Korff M, Quon B, Cantrell KL, Bowers MT, Lal R, Feinstein SC.

J Neurochem. 2016 Jun;137(6):939-54. doi: 10.1111/jnc.13604. Epub 2016 Apr 20.

PMID:
26953146
2.

Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels.

Do TD, LaPointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan S, Feinstein SC, Teplow DB, Eisenberg D, Shea JE, Bowers MT.

J Am Chem Soc. 2016 Jan 20;138(2):549-57. doi: 10.1021/jacs.5b09536. Epub 2016 Jan 6.

PMID:
26700445
3.

Amino Acid Metaclusters: Implications of Growth Trends on Peptide Self-Assembly and Structure.

Do TD, de Almeida NE, LaPointe NE, Chamas A, Feinstein SC, Bowers MT.

Anal Chem. 2016 Jan 5;88(1):868-76. doi: 10.1021/acs.analchem.5b03454. Epub 2015 Dec 15.

PMID:
26632663
4.

Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25-35 Assembly.

de Almeida NE, Do TD, Tro M, LaPointe NE, Feinstein SC, Shea JE, Bowers MT.

ACS Chem Neurosci. 2016 Feb 17;7(2):218-26. doi: 10.1021/acschemneuro.5b00280. Epub 2015 Dec 10.

PMID:
26629788
5.

Tau Aggregation Propensity Engrained in Its Solution State.

Eschmann NA, Do TD, LaPointe NE, Shea JE, Feinstein SC, Bowers MT, Han S.

J Phys Chem B. 2015 Nov 12;119(45):14421-32. doi: 10.1021/acs.jpcb.5b08092. Epub 2015 Oct 28.

PMID:
26484390
6.

Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.

Ganguly P, Do TD, Larini L, LaPointe NE, Sercel AJ, Shade MF, Feinstein SC, Bowers MT, Shea JE.

J Phys Chem B. 2015 Apr 2;119(13):4582-93. doi: 10.1021/acs.jpcb.5b00175. Epub 2015 Mar 24.

7.

Regulation and aggregation of intrinsically disordered peptides.

Levine ZA, Larini L, LaPointe NE, Feinstein SC, Shea JE.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2758-63. doi: 10.1073/pnas.1418155112. Epub 2015 Feb 17.

8.

Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants.

Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT.

J Phys Chem B. 2014 Jul 3;118(26):7247-56. doi: 10.1021/jp502473s. Epub 2014 Jun 18.

9.

Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro.

Yu D, LaPointe NE, Guzman E, Pessino V, Wilson L, Feinstein SC, Valentine MT.

J Alzheimers Dis. 2014;39(2):301-14. doi: 10.3233/JAD-131274.

PMID:
24150109
10.

A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function.

Iyer A, Lapointe NE, Zielke K, Berdynski M, Guzman E, Barczak A, Chodakowska-Żebrowska M, Barcikowska M, Feinstein S, Zekanowski C.

PLoS One. 2013 Sep 27;8(9):e76409. doi: 10.1371/journal.pone.0076409. eCollection 2013.

11.

Effects of pH and charge state on peptide assembly: the YVIFL model system.

Do TD, LaPointe NE, Economou NJ, Buratto SK, Feinstein SC, Shea JE, Bowers MT.

J Phys Chem B. 2013 Sep 19;117(37):10759-68. doi: 10.1021/jp406066d. Epub 2013 Sep 4.

PMID:
23937333
12.

Factors that drive peptide assembly and fibril formation: experimental and theoretical analysis of Sup35 NNQQNY mutants.

Do TD, Economou NJ, LaPointe NE, Kincannon WM, Bleiholder C, Feinstein SC, Teplow DB, Buratto SK, Bowers MT.

J Phys Chem B. 2013 Jul 18;117(28):8436-46. doi: 10.1021/jp4046287. Epub 2013 Jul 9.

PMID:
23802812
13.

Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.

LaPointe NE, Morfini G, Brady ST, Feinstein SC, Wilson L, Jordan MA.

Neurotoxicology. 2013 Jul;37:231-9. doi: 10.1016/j.neuro.2013.05.008. Epub 2013 May 24.

14.

Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study.

Larini L, Gessel MM, LaPointe NE, Do TD, Bowers MT, Feinstein SC, Shea JE.

Phys Chem Chem Phys. 2013 Jun 21;15(23):8916-28. doi: 10.1039/c3cp00063j. Epub 2013 Mar 20.

15.

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST.

Neurobiol Aging. 2012 Apr;33(4):826.e15-30. doi: 10.1016/j.neurobiolaging.2011.06.006. Epub 2011 Jul 27.

16.

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.

Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI.

J Neurosci. 2011 Jul 6;31(27):9858-68. doi: 10.1523/JNEUROSCI.0560-11.2011.

17.

Tau isoform-specific modulation of kinesin-driven microtubule gliding rates and trajectories as determined with tau-stabilized microtubules.

Peck A, Sargin ME, LaPointe NE, Rose K, Manjunath BS, Feinstein SC, Wilson L.

Cytoskeleton (Hoboken). 2011 Jan;68(1):44-55. doi: 10.1002/cm.20494. Epub 2010 Nov 10.

PMID:
21162159
18.

The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules.

Yenjerla M, LaPointe NE, Lopus M, Cox C, Jordan MA, Feinstein SC, Wilson L.

J Alzheimers Dis. 2010;19(4):1377-86. doi: 10.3233/JAD-2010-1335.

19.

Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro.

Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI.

Biochemistry. 2009 Dec 29;48(51):12290-7. doi: 10.1021/bi901304u.

20.

Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro.

Peterson DW, George RC, Scaramozzino F, LaPointe NE, Anderson RA, Graves DJ, Lew J.

J Alzheimers Dis. 2009;17(3):585-97. doi: 10.3233/JAD-2009-1083.

PMID:
19433898
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