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Results: 10

1.

Structural dynamics flexibility informs function and evolution at a proteome scale.

Nevin Gerek Z, Kumar S, Banu Ozkan S.

Evol Appl. 2013 Apr;6(3):423-33. doi: 10.1111/eva.12052. Epub 2013 Feb 13.

PMID:
23745135
[PubMed]
Free PMC Article
2.

Evolutionary balancing is critical for correctly forecasting disease-associated amino acid variants.

Liu L, Kumar S.

Mol Biol Evol. 2013 Jun;30(6):1252-7. doi: 10.1093/molbev/mst037. Epub 2013 Mar 5.

PMID:
23462317
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The evolutionary history of amino acid variations mediating increased resistance of S. aureus identifies reversion mutations in metabolic regulators.

Champion MD, Gray V, Eberhard C, Kumar S.

PLoS One. 2013;8(2):e56466. doi: 10.1371/journal.pone.0056466. Epub 2013 Feb 12.

PMID:
23424663
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Evolutionary diagnosis method for variants in personal exomes.

Kumar S, Sanderford M, Gray VE, Ye J, Liu L.

Nat Methods. 2012 Sep;9(9):855-6. doi: 10.1038/nmeth.2147. No abstract available.

PMID:
22936163
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Purifying selection modulates the estimates of population differentiation and confounds genome-wide comparisons across single-nucleotide polymorphisms.

Maruki T, Kumar S, Kim Y.

Mol Biol Evol. 2012 Dec;29(12):3617-23. doi: 10.1093/molbev/mss187. Epub 2012 Jul 23.

PMID:
22826460
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutations.

Gray VE, Kukurba KR, Kumar S.

Bioinformatics. 2012 Aug 15;28(16):2093-6. doi: 10.1093/bioinformatics/bts336. Epub 2012 Jun 8.

PMID:
22685075
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Human genomic disease variants: a neutral evolutionary explanation.

Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, Butte AJ, Kumar S.

Genome Res. 2012 Aug;22(8):1383-94. doi: 10.1101/gr.133702.111. Epub 2012 Jun 4. Review.

PMID:
22665443
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery.

Dudley JT, Chen R, Sanderford M, Butte AJ, Kumar S.

Mol Biol Evol. 2012 Sep;29(9):2087-94. doi: 10.1093/molbev/mss079. Epub 2012 Mar 1.

PMID:
22389448
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.

Kumar S, Dudley JT, Filipski A, Liu L.

Trends Genet. 2011 Sep;27(9):377-86. doi: 10.1016/j.tig.2011.06.004. Epub 2011 Jul 20. Review.

PMID:
21764165
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Rampant purifying selection conserves positions with posttranslational modifications in human proteins.

Gray VE, Kumar S.

Mol Biol Evol. 2011 May;28(5):1565-8. doi: 10.1093/molbev/msr013. Epub 2011 Jan 27.

PMID:
21273632
[PubMed - indexed for MEDLINE]
Free PMC Article

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