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Clin Calcium. 2010 Feb;20(2):225-33. doi: CliCa1002225233.

[Bone and Men's Health. Bone selective androgen receptor modulators].

[Article in Japanese]

Author information

  • Research Planning & Coordination Department, Central Research Laboratories, Kaken Pharmaceutical Co., Ltd..

Abstract

Androgen, one of the sex steroid hormones shows various biological activities on the corresponding various tissues. Many efforts to produce novel drug materials maintaining a desired biological activity with an adequate tissue selectivity, which is so-called selective androgen receptor modulators (SARMs) , are being performed. As one of such efforts, studies on SARMs against bone tissues which possess a significant potential to stimulate a bone formation with reducing undesirable androgenic virilizing activities are in progress all over the world. This review focuses on the research and development activities of such SARMs and discuses their usefulness for the treatment of osteoporosis.

PMID:
20118515
[PubMed - indexed for MEDLINE]
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