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Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.
Cheung CS, Chung KK, Lui JC, Lau CP, Hon PM, Chan JY, Fung KP, Au SW. Cheung CS, et al. Cancer Lett. 2007 Aug 18;253(2):224-35. doi: 10.1016/j.canlet.2007.01.025. Epub 2007 Mar 26. Cancer Lett. 2007. PMID: 17379399
The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line Hep …
The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this st …
Flavonoids as CYP3A4 Inhibitors In Vitro.
Kondža M, Brizić I, Jokić S. Kondža M, et al. Biomedicines. 2024 Mar 13;12(3):644. doi: 10.3390/biomedicines12030644. Biomedicines. 2024. PMID: 38540257 Free PMC article. Review.
This review delves into the scientific evidence surrounding flavonoid-mediated CYP3A4 inhibition, exploring the inhibitory potential of investigated flavonoids and future implications. Kusehnol I, chrysin, leachianone A, and sophoraflavone G showed the largest inhib …
This review delves into the scientific evidence surrounding flavonoid-mediated CYP3A4 inhibition, exploring the inhibitory potential of inve …
Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase.
Huang Y, Hao J, Tian D, Wen Y, Zhao P, Chen H, Lv Y, Yang X. Huang Y, et al. Front Pharmacol. 2018 Jul 16;9:760. doi: 10.3389/fphar.2018.00760. eCollection 2018. Front Pharmacol. 2018. PMID: 30061831 Free PMC article.
Four main flavonoids of SD-FRE namely apigenin, maackiain, leachianone A and leachianone B were purified and identified. In vitro, SD-FRE significantly promoted the translocation and expression of glucose transporter 4 (GLUT4) in L6 cells, which was significantly in …
Four main flavonoids of SD-FRE namely apigenin, maackiain, leachianone A and leachianone B were purified and identified. In vi …
Bioactivity-guided isolation of compounds from Sophora flavescens with antibacterial activity against Acinetobacter baumannii.
Li P, Chai WC, Wang ZY, Tang KJ, Chen JY, Venter H, Semple SJ, Xiang L. Li P, et al. Nat Prod Res. 2022 Sep;36(17):4340-4348. doi: 10.1080/14786419.2021.1983570. Epub 2021 Oct 1. Nat Prod Res. 2022. PMID: 34592853
Bioactivity-guided fraction of an extract of Sophora flavescens to identify antibacterial compounds against Acinetobacter baumannii, led to the isolation of two new compounds, (2"R)-5-methoxy-7-hydroxy-8-lavandulylchromone (13) and (2S,betaS)-(-)-sophobiflavonoid CE (19), and 18 …
Bioactivity-guided fraction of an extract of Sophora flavescens to identify antibacterial compounds against Acinetobacter baumannii, led to …
The anti-inflammatory activity of flavonoids and alkaloids from Sophora flavescens alleviates psoriasiform lesions: Prenylation and methoxylation beneficially enhance bioactivity and skin targeting.
Lin CF, Lin MH, Hung CF, Alshetaili A, Tsai YF, Jhong CL, Fang JY. Lin CF, et al. Phytother Res. 2024 Apr;38(4):1951-1970. doi: 10.1002/ptr.8140. Epub 2024 Feb 15. Phytother Res. 2024. PMID: 38358770
The ability of flavonoids (maackiain, sophoraflavanone G, leachianone A) and alkaloids (matrine, oxymatrine) isolated from S. flavescens to inhibit production of cytokine/chemokines was examined in keratinocytes and macrophages. ...In the IVPT, prenylation of the fl …
The ability of flavonoids (maackiain, sophoraflavanone G, leachianone A) and alkaloids (matrine, oxymatrine) isolated from S. …
Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes.
Yim D, Kim MJ, Shin Y, Lee SJ, Shin JG, Kim DH. Yim D, et al. Evid Based Complement Alternat Med. 2019 Mar 13;2019:2673769. doi: 10.1155/2019/2673769. eCollection 2019. Evid Based Complement Alternat Med. 2019. PMID: 31001351 Free PMC article.
Prenylated flavonoids also inhibited CYP isoforms with different selectivity and modes of action. Kushenol I, leachianone A, and sophoraflavone G inhibited CYP2B6, whereas kushenol C, kushenol I, kushenol M, leachianone A, and sophoraflavone G inhibite …
Prenylated flavonoids also inhibited CYP isoforms with different selectivity and modes of action. Kushenol I, leachianone A, a …
Cytotoxic lavandulyl flavanones from Sophora flavescens.
Kang TH, Jeong SJ, Ko WG, Kim NY, Lee BH, Inagaki M, Miyamoto T, Higuchi R, Kim YC. Kang TH, et al. J Nat Prod. 2000 May;63(5):680-1. doi: 10.1021/np990567x. J Nat Prod. 2000. PMID: 10843587
Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, form …
Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, …
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Zhu XF, Sun ZL, Ma J, Hu B, Yu MC, Liu XJ, Yang P, Xu Y, Ju D, Mu Q. Zhu XF, et al. Phytother Res. 2023 Feb;37(2):592-610. doi: 10.1002/ptr.7637. Epub 2022 Sep 30. Phytother Res. 2023. PMID: 36180975
In the experiment, most compounds were found to prominently enhance the inhibitory effects of SF on HCC cells than their alone treatment. Among them, three compounds leachianone A (1), sophoraflavanone G (3), and trifolirhizin (17) exhibited significantly synergisti …
In the experiment, most compounds were found to prominently enhance the inhibitory effects of SF on HCC cells than their alone treatment. Am …
Stilbene oligomers in roots of Sophora davidii.
Tanaka T, Ito T, Iinuma M, Ohyama M, Ichise M, Tateishi Y. Tanaka T, et al. Phytochemistry. 2000 Apr;53(8):1009-14. doi: 10.1016/s0031-9422(00)00016-9. Phytochemistry. 2000. PMID: 10820822
Three stilbene oligomers, davidiols A-C were isolated from the roots of Sophora davidii in addition to the seven known phenols, leachianone A, sophoraflavanones G, H and I, miyabenol C, alpha-viniferin and epsilon-viniferin. ...
Three stilbene oligomers, davidiols A-C were isolated from the roots of Sophora davidii in addition to the seven known phenols, leachiano …
16 results