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Results: 1 to 20 of 355

1.

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid.

Gutiérrez-Fernández A, Soria-Valles C, Osorio FG, Gutiérrez-Abril J, Garabaya C, Aguirre A, Fueyo A, Fernández-García MS, Puente XS, López-Otín C.

EMBO J. 2015 May 19. pii: e201490594. [Epub ahead of print]

PMID:
25991604
2.

New roles for mitochondrial proteases in health, ageing and disease.

Quirós PM, Langer T, López-Otín C.

Nat Rev Mol Cell Biol. 2015 Jun;16(6):345-59. doi: 10.1038/nrm3984. Epub 2015 May 13.

PMID:
25970558
3.

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis.

Cabrera S, Maciel M, Herrera I, Nava T, Vergara F, Gaxiola M, López-Otín C, Selman M, Pardo A.

Autophagy. 2015 Apr 3;11(4):670-84. doi: 10.1080/15548627.2015.1034409.

PMID:
25906080
4.

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.

Aguilera Ó, González-Sancho JM, Zazo S, Rincón R, Fernández AF, Tapia O, Canals F, Morte B, Calvanese V, Orgaz JL, Niell N, Aguilar S, Freije JM, Graña O, Pisano DG, Borrero A, Martínez-Useros J, Jiménez B, Fraga MF, García-Foncillas J, López-Otín C, Lafarga M, Rojo F, Muñoz A.

Oncotarget. 2015 Mar 20;6(8):5903-17.

5.

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

Bassaganyas L, Beà S, Escaramís G, Tornador C, Salaverria I, Zapata L, Drechsel O, Ferreira PG, Rodriguez-Santiago B, Tubio JM, Navarro A, Martín-García D, López C, Martínez-Trillos A, López-Guillermo A, Gut M, Ossowski S, López-Otín C, Campo E, Estivill X.

Leukemia. 2015 Mar;29(3):758. doi: 10.1038/leu.2014.309. No abstract available.

PMID:
25738466
6.

The functional and pathologic relevance of autophagy proteases.

Fernández ÁF, López-Otín C.

J Clin Invest. 2015 Jan;125(1):33-41. doi: 10.1172/JCI73940. Epub 2015 Jan 2. Review.

PMID:
25654548
7.

ADAMTS proteases and cancer.

Cal S, López-Otín C.

Matrix Biol. 2015 Jan 28. pii: S0945-053X(15)00027-X. doi: 10.1016/j.matbio.2015.01.013. [Epub ahead of print] Review.

8.

Molecular pathogenesis of CLL and its evolution.

Rodríguez D, Bretones G, Arango JR, Valdespino V, Campo E, Quesada V, López-Otín C.

Int J Hematol. 2015 Mar;101(3):219-28. doi: 10.1007/s12185-015-1733-0. Epub 2015 Jan 29.

PMID:
25630433
9.

Insights into the evolution of longevity from the bowhead whale genome.

Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T, Madsen LB, van Dam S, Brawand D, Marques PI, Michalak P, Kang L, Bhak J, Yim HS, Grishin NV, Nielsen NH, Heide-Jørgensen MP, Oziolor EM, Matson CW, Church GM, Stuart GW, Patton JC, George JC, Suydam R, Larsen K, López-Otín C, O'Connell MJ, Bickham JW, Thomsen B, de Magalhães JP.

Cell Rep. 2015 Jan 6;10(1):112-22. doi: 10.1016/j.celrep.2014.12.008.

10.

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.

Aoude LG, Pritchard AL, Robles-Espinoza CD, Wadt K, Harland M, Choi J, Gartside M, Quesada V, Johansson P, Palmer JM, Ramsay AJ, Zhang X, Jones K, Symmons J, Holland EA, Schmid H, Bonazzi V, Woods S, Dutton-Regester K, Stark MS, Snowden H, van Doorn R, Montgomery GW, Martin NG, Keane TM, López-Otín C, Gerdes AM, Olsson H, Ingvar C, Borg A, Gruis NA, Trent JM, Jönsson G, Bishop DT, Mann GJ, Newton-Bishop JA, Brown KM, Adams DJ, Hayward NK.

J Natl Cancer Inst. 2014 Dec 13;107(2). pii: dju408. doi: 10.1093/jnci/dju408. Print 2015 Feb.

PMID:
25505254
11.

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction.

Wallace DF, Secondes ES, Rishi G, Ostini L, McDonald CJ, Lane SW, Vu T, Hooper JD, Velasco G, Ramsay AJ, Lopez-Otin C, Subramaniam VN.

Br J Haematol. 2015 Mar;168(6):891-901. doi: 10.1111/bjh.13225. Epub 2014 Nov 17.

PMID:
25403101
12.

Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy.

Valdés-Mas R, Gutiérrez-Fernández A, Gómez J, Coto E, Astudillo A, Puente DA, Reguero JR, Álvarez V, Morís C, León D, Martín M, Puente XS, López-Otín C.

Nat Commun. 2014 Oct 29;5:5326. doi: 10.1038/ncomms6326.

PMID:
25351925
13.

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads.

Moncunill V, Gonzalez S, Beà S, Andrieux LO, Salaverria I, Royo C, Martinez L, Puiggròs M, Segura-Wang M, Stütz AM, Navarro A, Royo R, Gelpí JL, Gut IG, López-Otín C, Orozco M, Korbel JO, Campo E, Puente XS, Torrents D.

Nat Biotechnol. 2014 Nov;32(11):1106-12. doi: 10.1038/nbt.3027. Epub 2014 Oct 26.

PMID:
25344728
14.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19.

15.

Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness.

Baixauli F, López-Otín C, Mittelbrunn M.

Front Immunol. 2014 Aug 20;5:403. doi: 10.3389/fimmu.2014.00403. eCollection 2014. Review.

16.

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.

Queirós AC, Villamor N, Clot G, Martinez-Trillos A, Kulis M, Navarro A, Penas EM, Jayne S, Majid A, Richter J, Bergmann AK, Kolarova J, Royo C, Russiñol N, Castellano G, Pinyol M, Bea S, Salaverria I, López-Guerra M, Colomer D, Aymerich M, Rozman M, Delgado J, Giné E, González-Díaz M, Puente XS, Siebert R, Dyer MJ, López-Otín C, Rozman C, Campo E, López-Guillermo A, Martín-Subero JI.

Leukemia. 2015 Mar;29(3):598-605. doi: 10.1038/leu.2014.252. Epub 2014 Aug 25.

PMID:
25151957
17.

ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity.

Quirós PM, Español Y, Acín-Pérez R, Rodríguez F, Bárcena C, Watanabe K, Calvo E, Loureiro M, Fernández-García MS, Fueyo A, Vázquez J, Enríquez JA, López-Otín C.

Cell Rep. 2014 Jul 24;8(2):542-56. doi: 10.1016/j.celrep.2014.06.018. Epub 2014 Jul 10.

18.

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.

Porlan E, Martí-Prado B, Morante-Redolat JM, Consiglio A, Delgado AC, Kypta R, López-Otín C, Kirstein M, Fariñas I.

Nat Cell Biol. 2014 Jul;16(7):629-38. doi: 10.1038/ncb2993. Epub 2014 Jun 22.

PMID:
24952463
19.

Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.

Willemetz A, Lenoir A, Deschemin JC, Lopez-Otin C, Ramsay AJ, Vaulont S, Nicolas G.

Blood. 2014 Jul 17;124(3):441-4. doi: 10.1182/blood-2014-01-551150. Epub 2014 Jun 5.

PMID:
24904115
20.

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome.

Bárcena C, Quesada V, De Sandre-Giovannoli A, Puente DA, Fernández-Toral J, Sigaudy S, Baban A, Lévy N, Velasco G, López-Otín C.

BMC Med Genet. 2014 May 2;15:51. doi: 10.1186/1471-2350-15-51.

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