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Results: 1 to 20 of 340

1.

A B-cell epigenetic signature defines three biological subgroups of chronic lymphocytic leukemia with clinical impact.

Queirós AC, Villamor N, Clot G, Martinez-Trillos A, Kulis M, Navarro A, Penas EM, Jayne S, Majid A, Richter J, Bergmann AK, Kolarova J, Royo C, Russiñol N, Castellano G, Pinyol M, Bea S, Salaverria I, López-Guerra M, Colomer D, Aymerich M, Rozman M, Delgado J, Giné E, González-Díaz M, Puente XS, Siebert R, Dyer MJ, López-Otín C, Rozman C, Campo E, López-Guillermo A, Martín-Subero JI.

Leukemia. 2014 Aug 25. doi: 10.1038/leu.2014.252. [Epub ahead of print]

PMID:
25151957
[PubMed - as supplied by publisher]
2.

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity.

Quirós PM, Español Y, Acín-Pérez R, Rodríguez F, Bárcena C, Watanabe K, Calvo E, Loureiro M, Fernández-García MS, Fueyo A, Vázquez J, Enríquez JA, López-Otín C.

Cell Rep. 2014 Jul 24;8(2):542-56. doi: 10.1016/j.celrep.2014.06.018. Epub 2014 Jul 10.

PMID:
25017063
[PubMed - in process]
Free Article
3.

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.

Porlan E, Martí-Prado B, Morante-Redolat JM, Consiglio A, Delgado AC, Kypta R, López-Otín C, Kirstein M, Fariñas I.

Nat Cell Biol. 2014 Jul;16(7):629-38. doi: 10.1038/ncb2993. Epub 2014 Jun 22.

PMID:
24952463
[PubMed - in process]
4.

Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.

Willemetz A, Lenoir A, Deschemin JC, Lopez-Otin C, Ramsay AJ, Vaulont S, Nicolas G.

Blood. 2014 Jul 17;124(3):441-4. doi: 10.1182/blood-2014-01-551150. Epub 2014 Jun 5.

PMID:
24904115
[PubMed - in process]
5.

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome.

Bárcena C, Quesada V, De Sandre-Giovannoli A, Puente DA, Fernández-Toral J, Sigaudy S, Baban A, Lévy N, Velasco G, López-Otín C.

BMC Med Genet. 2014 May 2;15:51. doi: 10.1186/1471-2350-15-51.

PMID:
24886349
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome.

Martínez-Trillos A, Pinyol M, Navarro A, Aymerich M, Jares P, Juan M, Rozman M, Colomer D, Delgado J, Giné E, González-Díaz M, Hernández-Rivas JM, Colado E, Rayón C, Payer AR, Terol MJ, Navarro B, Quesada V, Puente XS, Rozman C, López-Otín C, Campo E, López-Guillermo A, Villamor N.

Blood. 2014 Jun 12;123(24):3790-6. doi: 10.1182/blood-2013-12-543306. Epub 2014 Apr 29.

PMID:
24782504
[PubMed - indexed for MEDLINE]
7.

The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells.

López-Guerra M, Xargay-Torrent S, Rosich L, Montraveta A, Roldán J, Matas-Céspedes A, Villamor N, Aymerich M, López-Otín C, Pérez-Galán P, Roué G, Campo E, Colomer D.

Leukemia. 2014 Apr 30. doi: 10.1038/leu.2014.143. [Epub ahead of print]

PMID:
24781018
[PubMed - as supplied by publisher]
8.

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JM, López-Otín C, Sánchez-Madrid F, Andrés V.

Sci Signal. 2014 Apr 22;7(322):ra37. doi: 10.1126/scisignal.2004872.

PMID:
24757177
[PubMed - in process]
9.

The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy.

Santacruz R, Villamor N, Aymerich M, Martínez-Trillos A, López C, Navarro A, Rozman M, Beà S, Royo C, Cazorla M, Colomer D, Giné E, Pinyol M, Puente XS, López-Otín C, Campo E, López-Guillermo A, Delgado J.

Haematologica. 2014 May;99(5):873-80. doi: 10.3324/haematol.2013.099796. Epub 2014 Apr 3.

PMID:
24700492
[PubMed - in process]
Free PMC Article
10.

POT1 loss-of-function variants predispose to familial melanoma.

Robles-Espinoza CD, Harland M, Ramsay AJ, Aoude LG, Quesada V, Ding Z, Pooley KA, Pritchard AL, Tiffen JC, Petljak M, Palmer JM, Symmons J, Johansson P, Stark MS, Gartside MG, Snowden H, Montgomery GW, Martin NG, Liu JZ, Choi J, Makowski M, Brown KM, Dunning AM, Keane TM, López-Otín C, Gruis NA, Hayward NK, Bishop DT, Newton-Bishop JA, Adams DJ.

Nat Genet. 2014 May;46(5):478-81. doi: 10.1038/ng.2947. Epub 2014 Mar 30.

PMID:
24686849
[PubMed - indexed for MEDLINE]
11.

OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.

Xiao X, Hu Y, Quirós PM, Wei Q, López-Otín C, Dong Z.

Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1318-26. doi: 10.1152/ajprenal.00036.2014. Epub 2014 Mar 26.

PMID:
24671334
[PubMed - indexed for MEDLINE]
12.

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM.

Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17.

PMID:
24636986
[PubMed - indexed for MEDLINE]
13.

Regulation of autophagy by cytosolic acetyl-coenzyme A.

Mariño G, Pietrocola F, Eisenberg T, Kong Y, Malik SA, Andryushkova A, Schroeder S, Pendl T, Harger A, Niso-Santano M, Zamzami N, Scoazec M, Durand S, Enot DP, Fernández ÁF, Martins I, Kepp O, Senovilla L, Bauvy C, Morselli E, Vacchelli E, Bennetzen M, Magnes C, Sinner F, Pieber T, López-Otín C, Maiuri MC, Codogno P, Andersen JS, Hill JA, Madeo F, Kroemer G.

Mol Cell. 2014 Mar 6;53(5):710-25. doi: 10.1016/j.molcel.2014.01.016. Epub 2014 Feb 20.

PMID:
24560926
[PubMed - indexed for MEDLINE]
14.

Progeria: a paradigm for translational medicine.

Gordon LB, Rothman FG, López-Otín C, Misteli T.

Cell. 2014 Jan 30;156(3):400-7. doi: 10.1016/j.cell.2013.12.028.

PMID:
24485450
[PubMed - indexed for MEDLINE]
15.

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.

Ferreira PG, Jares P, Rico D, Gómez-López G, Martínez-Trillos A, Villamor N, Ecker S, González-Pérez A, Knowles DG, Monlong J, Johnson R, Quesada V, Djebali S, Papasaikas P, López-Guerra M, Colomer D, Royo C, Cazorla M, Pinyol M, Clot G, Aymerich M, Rozman M, Kulis M, Tamborero D, Gouin A, Blanc J, Gut M, Gut I, Puente XS, Pisano DG, Martin-Subero JI, López-Bigas N, López-Guillermo A, Valencia A, López-Otín C, Campo E, Guigó R.

Genome Res. 2014 Feb;24(2):212-26. doi: 10.1101/gr.152132.112. Epub 2013 Nov 21.

PMID:
24265505
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Next-generation sequencing in chronic lymphocytic leukemia.

Villamor N, López-Guillermo A, López-Otín C, Campo E.

Semin Hematol. 2013 Oct;50(4):286-95. doi: 10.1053/j.seminhematol.2013.09.005. Review.

PMID:
24246696
[PubMed - indexed for MEDLINE]
17.

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas.

Fraile JM, Ordóñez GR, Quirós PM, Astudillo A, Galván JA, Colomer D, López-Otín C, Freije JM, Puente XS.

Oncotarget. 2013 Nov;4(11):1931-2.

PMID:
24243807
[PubMed - in process]
Free Article
18.

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Di Croce L, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18250-5. doi: 10.1073/pnas.1314608110. Epub 2013 Oct 21.

PMID:
24145436
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

Fanjul-Fernández M, Quesada V, Cabanillas R, Cadiñanos J, Fontanil T, Obaya A, Ramsay AJ, Llorente JL, Astudillo A, Cal S, López-Otín C.

Nat Commun. 2013;4:2531. doi: 10.1038/ncomms3531.

PMID:
24100690
[PubMed - indexed for MEDLINE]
20.

Recurrent gene mutations in CLL.

Martínez-Trillos A, Quesada V, Villamor N, Puente XS, López-Otín C, Campo E.

Adv Exp Med Biol. 2013;792:87-107. doi: 10.1007/978-1-4614-8051-8_4. Review.

PMID:
24014293
[PubMed - indexed for MEDLINE]

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