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Results: 1 to 20 of 42

1.

Systematic Annotation of Celiac Disease Loci Refines Pathological Pathways and Suggests a Genetic Explanation for Increased Interferon Gamma levels.

Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, Zhernakova A, Franke L, Lahesmaa R, Wijmenga C, Withoff S.

Hum Mol Genet. 2014 Sep 4. pii: ddu453. [Epub ahead of print]

PMID:
25190711
[PubMed - as supplied by publisher]
2.

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.

Tsagaratou A, Aijö T, Lio CW, Yue X, Huang Y, Jacobsen SE, Lähdesmäki H, Rao A.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3306-15. doi: 10.1073/pnas.1412327111. Epub 2014 Jul 28.

PMID:
25071199
[PubMed - in process]
3.

Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation.

Äijö T, Butty V, Chen Z, Salo V, Tripathi S, Burge CB, Lahesmaa R, Lähdesmäki H.

Bioinformatics. 2014 Jun 15;30(12):i113-20. doi: 10.1093/bioinformatics/btu274.

PMID:
24931974
[PubMed - in process]
Free PMC Article
4.

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B.

Nat Immunol. 2014 Apr;15(4):384-92. doi: 10.1038/ni.2843. Epub 2014 Mar 2.

PMID:
24584089
[PubMed - indexed for MEDLINE]
5.

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells.

Noisa P, Lund C, Kanduri K, Lund R, Lähdesmäki H, Lahesmaa R, Lundin K, Chokechuwattanalert H, Otonkoski T, Tuuri T, Raivio T.

J Cell Sci. 2014 May 1;127(Pt 9):2083-94. doi: 10.1242/jcs.145755. Epub 2014 Feb 25.

PMID:
24569875
[PubMed - in process]
6.

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R.

Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18.

PMID:
24550192
[PubMed - indexed for MEDLINE]
7.

Evaluating a linear k-mer model for protein-DNA interactions using high-throughput SELEX data.

Kähärä J, Lähdesmäki H.

BMC Bioinformatics. 2013;14 Suppl 10:S2. doi: 10.1186/1471-2105-14-S10-S2. Epub 2013 Aug 12.

PMID:
24267147
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.

Närvä E, Pursiheimo JP, Laiho A, Rahkonen N, Emani MR, Viitala M, Laurila K, Sahla R, Lund R, Lähdesmäki H, Jaakkola P, Lahesmaa R.

PLoS One. 2013 Nov 13;8(11):e78847. doi: 10.1371/journal.pone.0078847. eCollection 2013.

PMID:
24236059
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.

Hawkins RD, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H, Lahesmaa R.

Immunity. 2013 Jun 27;38(6):1271-84. doi: 10.1016/j.immuni.2013.05.011. Epub 2013 Jun 20.

PMID:
23791644
[PubMed - indexed for MEDLINE]
Free Article
10.

The genome-wide landscape of copy number variations in the MUSGEN study provides evidence for a founder effect in the isolated Finnish population.

Kanduri C, Ukkola-Vuoti L, Oikkonen J, Buck G, Blancher C, Raijas P, Karma K, Lähdesmäki H, Järvelä I.

Eur J Hum Genet. 2013 Dec;21(12):1411-6. doi: 10.1038/ejhg.2013.60. Epub 2013 Apr 17.

PMID:
23591402
[PubMed - indexed for MEDLINE]
11.

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

Ko M, An J, Bandukwala HS, Chavez L, Aijö T, Pastor WA, Segal MF, Li H, Koh KP, Lähdesmäki H, Hogan PG, Aravind L, Rao A.

Nature. 2013 May 2;497(7447):122-6. doi: 10.1038/nature12052. Epub 2013 Apr 7.

PMID:
23563267
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Sorad: a systems biology approach to predict and modulate dynamic signaling pathway response from phosphoproteome time-course measurements.

Äijö T, Granberg K, Lähdesmäki H.

Bioinformatics. 2013 May 15;29(10):1283-91. doi: 10.1093/bioinformatics/btt130. Epub 2013 Mar 16.

PMID:
23505293
[PubMed - indexed for MEDLINE]
Free Article
13.

Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music.

Ukkola-Vuoti L, Kanduri C, Oikkonen J, Buck G, Blancher C, Raijas P, Karma K, Lähdesmäki H, Järvelä I.

PLoS One. 2013;8(2):e56356. doi: 10.1371/journal.pone.0056356. Epub 2013 Feb 27.

PMID:
23460800
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R.

J Biol Chem. 2013 Feb 1;288(5):3048-58. doi: 10.1074/jbc.M112.361709. Epub 2012 Dec 3.

PMID:
23209281
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structure learning for Bayesian networks as models of biological networks.

Larjo A, Shmulevich I, Lähdesmäki H.

Methods Mol Biol. 2013;939:35-45. doi: 10.1007/978-1-62703-107-3_4.

PMID:
23192539
[PubMed - indexed for MEDLINE]
16.

An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation.

Aijö T, Edelman SM, Lönnberg T, Larjo A, Kallionpää H, Tuomela S, Engström E, Lahesmaa R, Lähdesmäki H.

BMC Genomics. 2012 Oct 30;13:572. doi: 10.1186/1471-2164-13-572.

PMID:
23110343
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.

Benson MJ, Aijö T, Chang X, Gagnon J, Pape UJ, Anantharaman V, Aravind L, Pursiheimo JP, Oberdoerffer S, Liu XS, Lahesmaa R, Lähdesmäki H, Rao A.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16252-7. doi: 10.1073/pnas.1214414109. Epub 2012 Sep 18.

PMID:
22991471
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate.

Lehmusvaara S, Erkkilä T, Urbanucci A, Jalava S, Seppälä J, Kaipia A, Kujala P, Lähdesmäki H, Tammela TL, Visakorpi T.

Prostate. 2013 Jan;73(1):101-12. doi: 10.1002/pros.22545. Epub 2012 Jun 5.

PMID:
22674191
[PubMed - indexed for MEDLINE]
19.

Identification of early gene expression changes during human Th17 cell differentiation.

Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B, Lähdesmäki H, Lahesmaa R.

Blood. 2012 Jun 7;119(23):e151-60. doi: 10.1182/blood-2012-01-407528. Epub 2012 Apr 27.

PMID:
22544700
[PubMed - indexed for MEDLINE]
Free Article
20.

Chemical castration and anti-androgens induce differential gene expression in prostate cancer.

Lehmusvaara S, Erkkilä T, Urbanucci A, Waltering K, Seppälä J, Larjo A, Tuominen VJ, Isola J, Kujala P, Lähdesmäki H, Kaipia A, Tammela TLj, Visakorpi T.

J Pathol. 2012 Jul;227(3):336-45. doi: 10.1002/path.4027. Epub 2012 May 8.

PMID:
22431170
[PubMed - indexed for MEDLINE]

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