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Items: 1 to 20 of 82

1.

In the beginning, there was protein phosphorylation.

Kyriakis JM.

J Biol Chem. 2014 Apr 4;289(14):9460-2. doi: 10.1074/jbc.R114.557926. Epub 2014 Feb 19.

2.

Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice.

Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, Galper JB.

Diabetes. 2014 Jun;63(6):2097-113. doi: 10.2337/db12-1459. Epub 2014 Jan 23.

3.

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.

Kyriakis JM, Avruch J.

Physiol Rev. 2012 Apr;92(2):689-737. doi: 10.1152/physrev.00028.2011. Review.

4.

Retraction for Zhong et al. GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Gavrilescu LC, Molnár Á, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134. doi: 10.1073/pnas.1203089109. Epub 2012 Mar 12. No abstract available.

5.

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.

Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. doi: 10.1152/ajpcell.00211.2011. Epub 2011 Jul 20.

6.

Activation of SAPK/JNKs in vitro.

Chadee DN, Kyriakis JM.

Methods Mol Biol. 2010;661:59-73. doi: 10.1007/978-1-60761-795-2_3.

PMID:
20811976
8.

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.E09-09-0818. Epub 2010 Feb 24.

9.

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Zhong J, Gavrilescu LC, Molnár A, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7. doi: 10.1073/pnas.0812642106. Epub 2009 Feb 25. Retraction in: Gavrilescu LC, Molnár Á, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134.

10.

Thinking outside the box about Ras.

Kyriakis JM.

J Biol Chem. 2009 Apr 24;284(17):10993-4. doi: 10.1074/jbc.R800085200. Epub 2008 Dec 17. Review. No abstract available.

11.
12.

The integration of signaling by multiprotein complexes containing Raf kinases.

Kyriakis JM.

Biochim Biophys Acta. 2007 Aug;1773(8):1238-47. Epub 2006 Nov 7. Review.

13.
15.

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4463-8. Epub 2006 Mar 13.

16.
17.

A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.

Chadee DN, Kyriakis JM.

Cell Cycle. 2004 Oct;3(10):1227-9. Epub 2004 Oct 19.

PMID:
15467451
19.

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.

Chadee DN, Kyriakis JM.

Nat Cell Biol. 2004 Aug;6(8):770-6. Epub 2004 Jul 18.

PMID:
15258589
20.

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.

Circulation. 2004 Mar 16;109(10):1196-205. Review.

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