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Items: 1 to 20 of 353

1.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

Golani LK, Wallace-Povirk A, Deis SM, Wong JE, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin LA, de Waal PW, White K, Kushner J, O'Connor CE, Hou Z, Xu HE, Melcher K, Dann Iii CE, Matherly LH, Gangjee A.

J Med Chem. 2016 Jul 26. [Epub ahead of print]

PMID:
27458733
2.

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA.

PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.

3.

Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital.

Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS.

J Pediatr. 2016 May;172:5-6.e5. doi: 10.1016/j.jpeds.2016.02.002. No abstract available.

PMID:
27112081
4.

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage.

Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA.

Diabetologia. 2016 Jun;59(6):1231-41. doi: 10.1007/s00125-016-3922-7. Epub 2016 Mar 22.

5.

Extended-release Once-daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared with Immediate-release Tofacitinib and Impact of Food.

Lamba M, Wang R, Fletcher T, Alvey C, Kushner J, Stock TC.

J Clin Pharmacol. 2016 Mar 11. doi: 10.1002/jcph.734. [Epub ahead of print]

PMID:
26970526
6.

Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.

Wilson MR, Hou Z, Yang S, Polin L, Kushner J, White K, Huang J, Ratnam M, Gangjee A, Matherly LH.

Mol Pharmacol. 2016 Apr;89(4):425-34. doi: 10.1124/mol.115.102798. Epub 2016 Feb 2.

PMID:
26837243
7.

Research and Evaluations of the Health Aspects of Disasters, Part VI: Interventional Research and the Disaster Logic Model.

Birnbaum ML, Daily EK, O'Rourke AP, Kushner J.

Prehosp Disaster Med. 2016 Apr;31(2):181-94. doi: 10.1017/S1049023X16000017. Epub 2016 Feb 2.

PMID:
26830875
8.

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes.

Bansal N, Hampe CS, Rodriguez L, O'Brian Smith E, Kushner J, Balasubramanyam A, Redondo MJ.

Diabet Med. 2016 Jan 23. doi: 10.1111/dme.13077. [Epub ahead of print]

PMID:
26802570
9.

Nutritional Support on the Medical Wards--Thought for Food.

Kushner JP, Lacy JA, Gay SR.

JAMA Intern Med. 2016 Jan;176(1):53-4. doi: 10.1001/jamainternmed.2015.7062. No abstract available.

PMID:
26720103
10.

Type I interferons mediate pancreatic toxicities of PERK inhibition.

Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1.

11.

Doppler Systolic Signal Void in Hypertrophic Cardiomyopathy: Apical Aneurysm and Severe Obstruction without Elevated Intraventricular Velocities.

Po JR, Kim B, Aslam F, Arabadjian M, Winson G, Cantales D, Kushner J, Kornberg R, Sherrid MV.

J Am Soc Echocardiogr. 2015 Dec;28(12):1462-73. doi: 10.1016/j.echo.2015.08.015. Epub 2015 Sep 28.

PMID:
26422555
12.

Dissatisfaction with maintenance of certification in academic pediatrics.

Ackerman KG, Lee B, Kushner JA.

Pediatr Res. 2016 Feb;79(2):240-2. doi: 10.1038/pr.2015.189. Epub 2015 Sep 30. No abstract available.

PMID:
26421351
13.

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.

Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE 3rd, Matherly LH, Gangjee A.

J Med Chem. 2015 Sep 10;58(17):6938-59. doi: 10.1021/acs.jmedchem.5b00801. Epub 2015 Aug 28.

14.

Echocardiography before and after resect-plicate-release surgical myectomy for obstructive hypertrophic cardiomyopathy.

Halpern DG, Swistel DG, Po JR, Joshi R, Winson G, Arabadjian M, Lopresto C, Kushner J, Kim B, Balaram SK, Sherrid MV.

J Am Soc Echocardiogr. 2015 Nov;28(11):1318-28. doi: 10.1016/j.echo.2015.07.002. Epub 2015 Aug 10.

PMID:
26272699
15.

Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention.

Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M.

Pediatr Diabetes. 2015 Nov;16(7):465-84. doi: 10.1111/pedi.12299. Epub 2015 Jul 23. Review.

PMID:
26202050
16.

Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes.

Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA.

PLoS One. 2015 Jun 9;10(6):e0129809. doi: 10.1371/journal.pone.0129809. eCollection 2015.

17.

Phase I trial of low-dose oral Clofarabine in myelodysplastic syndromes patients who have failed frontline therapy.

Rudrapatna VK, Morley K, Boucher KM, Pierson AS, Shull CT, Kushner JP, Shami PJ.

Leuk Res. 2015 Aug;39(8):835-9. doi: 10.1016/j.leukres.2015.05.004. Epub 2015 May 18.

PMID:
26038120
18.

A method for determining δ-aminolevulinic acid synthase activity in homogenized cells and tissues.

Bergonia HA, Franklin MR, Kushner JP, Phillips JD.

Clin Biochem. 2015 Aug;48(12):788-95. doi: 10.1016/j.clinbiochem.2015.04.023. Epub 2015 May 8.

19.

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice.

Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA.

Diabetologia. 2015 Jul;58(7):1523-31. doi: 10.1007/s00125-015-3590-z. Epub 2015 Apr 28.

20.

Empowering a healthy practice environment.

Kushner J, Ruffin T.

Nurs Clin North Am. 2015 Mar;50(1):167-83. doi: 10.1016/j.cnur.2014.10.013. Epub 2014 Dec 13. Review.

PMID:
25680495
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