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Results: 1 to 20 of 180

1.

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT.

Science. 2014 Jul 4;345(6192):50-4. doi: 10.1126/science.1250373.

PMID:
24994643
[PubMed - indexed for MEDLINE]
2.

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12.

PMID:
24623852
[PubMed - indexed for MEDLINE]
3.

Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2014 Feb 11;3:e02490. doi: 10.7554/eLife.02490. No abstract available.

PMID:
24520169
[PubMed - in process]
Free PMC Article
4.

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2013 Jan 1;3:e01610. doi: 10.7554/eLife.01610.

PMID:
24473075
[PubMed - in process]
Free PMC Article
5.

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.

PMID:
23908768
[PubMed - in process]
Free PMC Article
6.

Macromolecular juggling by ubiquitylation enzymes.

Lorenz S, Cantor AJ, Rape M, Kuriyan J.

BMC Biol. 2013 Jun 25;11:65. doi: 10.1186/1741-7007-11-65. Review.

PMID:
23800009
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Fixing a hole where the Ras gets in.

Iwig JS, Kuriyan J.

Cell. 2013 Jun 6;153(6):1191-3. doi: 10.1016/j.cell.2013.05.029.

PMID:
23746837
[PubMed - indexed for MEDLINE]
Free Article
8.

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation.

Engel K, Sasaki T, Wang Q, Kuriyan J.

Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537.

PMID:
23734957
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A structural role for the PHP domain in E. coli DNA polymerase III.

Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH.

BMC Struct Biol. 2013 May 14;13:8. doi: 10.1186/1472-6807-13-8.

PMID:
23672456
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Stratton MM, Chao LH, Schulman H, Kuriyan J.

Curr Opin Struct Biol. 2013 Apr;23(2):292-301. doi: 10.1016/j.sbi.2013.04.002. Epub 2013 Apr 27. Review.

PMID:
23632248
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.

PMID:
23530057
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Architecture and membrane interactions of the EGF receptor.

Arkhipov A, Shan Y, Das R, Endres NF, Eastwood MP, Wemmer DE, Kuriyan J, Shaw DE.

Cell. 2013 Jan 31;152(3):557-69. doi: 10.1016/j.cell.2012.12.030.

PMID:
23374350
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Conformational coupling across the plasma membrane in activation of the EGF receptor.

Endres NF, Das R, Smith AW, Arkhipov A, Kovacs E, Huang Y, Pelton JG, Shan Y, Shaw DE, Wemmer DE, Groves JT, Kuriyan J.

Cell. 2013 Jan 31;152(3):543-56. doi: 10.1016/j.cell.2012.12.032.

PMID:
23374349
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A.

Sci Signal. 2013 Jan 1;6(256):ra1. doi: 10.1126/scisignal.2003220.

PMID:
23281368
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE.

Cell. 2012 May 11;149(4):860-70. doi: 10.1016/j.cell.2012.02.063.

PMID:
22579287
[PubMed - indexed for MEDLINE]
Free Article
16.

Clamp loader ATPases and the evolution of DNA replication machinery.

Kelch BA, Makino DL, O'Donnell M, Kuriyan J.

BMC Biol. 2012 Apr 20;10:34. doi: 10.1186/1741-7007-10-34.

PMID:
22520345
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP.

Nature. 2012 Apr 15;485(7397):260-3. doi: 10.1038/nature11016.

PMID:
22504184
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

How a DNA polymerase clamp loader opens a sliding clamp.

Kelch BA, Makino DL, O'Donnell M, Kuriyan J.

Science. 2011 Dec 23;334(6063):1675-80. doi: 10.1126/science.1211884.

PMID:
22194570
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.

Winter MB, Herzik MA Jr, Kuriyan J, Marletta MA.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E881-9. doi: 10.1073/pnas.1114038108. Epub 2011 Oct 12.

PMID:
21997213
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.

Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J.

Cell. 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038. Erratum in: Cell. 2011 Oct 28;147(3):704.

PMID:
21884935
[PubMed - indexed for MEDLINE]
Free PMC Article

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