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Results: 1 to 20 of 188

1.

Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220).

Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J.

PLoS One. 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177. eCollection 2015.

2.

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Lorenz SG, Deng P, Hantschel O, Superti-Furga G, Kuriyan J.

Biochem J. 2015 Mar 17. [Epub ahead of print]

3.

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J.

Elife. 2015 Feb 20;4. doi: 10.7554/eLife.06074.

4.

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor.

Kovacs E, Zorn JA, Huang Y, Barros T, Kuriyan J.

Annu Rev Biochem. 2015 Jan 26. [Epub ahead of print]

PMID:
25621509
5.

A structural atlas of kinases inhibited by clinically approved drugs.

Wang Q, Zorn JA, Kuriyan J.

Methods Enzymol. 2014;548:23-67. doi: 10.1016/B978-0-12-397918-6.00002-1.

PMID:
25399641
6.

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J.

Biochem J. 2015 Jan 1;465(1):149-61. doi: 10.1042/BJ20140793.

PMID:
25287889
7.

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.

Herzik MA Jr, Jonnalagadda R, Kuriyan J, Marletta MA.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4156-64. doi: 10.1073/pnas.1416936111. Epub 2014 Sep 24.

8.

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.

Endres NF, Barros T, Cantor AJ, Kuriyan J.

Trends Biochem Sci. 2014 Oct;39(10):437-46. doi: 10.1016/j.tibs.2014.08.001. Epub 2014 Sep 18. Review.

PMID:
25242369
9.

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT.

Science. 2014 Jul 4;345(6192):50-4. doi: 10.1126/science.1250373.

10.

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12.

11.

Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2014 Feb 11;3:e02490. doi: 10.7554/eLife.02490. No abstract available.

12.

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2013 Jan 1;3:e01610. doi: 10.7554/eLife.01610.

13.

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.

14.

Macromolecular juggling by ubiquitylation enzymes.

Lorenz S, Cantor AJ, Rape M, Kuriyan J.

BMC Biol. 2013 Jun 25;11:65. doi: 10.1186/1741-7007-11-65. Review.

15.

Fixing a hole where the Ras gets in.

Iwig JS, Kuriyan J.

Cell. 2013 Jun 6;153(6):1191-3. doi: 10.1016/j.cell.2013.05.029.

16.

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation.

Engel K, Sasaki T, Wang Q, Kuriyan J.

Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537.

17.

A structural role for the PHP domain in E. coli DNA polymerase III.

Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH.

BMC Struct Biol. 2013 May 14;13:8. doi: 10.1186/1472-6807-13-8.

18.

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Stratton MM, Chao LH, Schulman H, Kuriyan J.

Curr Opin Struct Biol. 2013 Apr;23(2):292-301. doi: 10.1016/j.sbi.2013.04.002. Epub 2013 Apr 27. Review.

19.

Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.

20.

Architecture and membrane interactions of the EGF receptor.

Arkhipov A, Shan Y, Das R, Endres NF, Eastwood MP, Wemmer DE, Kuriyan J, Shaw DE.

Cell. 2013 Jan 31;152(3):557-69. doi: 10.1016/j.cell.2012.12.030.

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