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Items: 1 to 20 of 195

1.

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8218-23. doi: 10.1073/pnas.1602602113. Epub 2016 Jul 1.

PMID:
27370798
2.

Molecular basis for multimerization in the activation of the epidermal growth factor receptor.

Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J.

Elife. 2016 Mar 28;5. pii: e14107. doi: 10.7554/eLife.14107.

3.

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.

Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams ER, Kuriyan J.

Elife. 2016 Mar 7;5. pii: e13405. doi: 10.7554/eLife.13405.

4.

Crystal Structure of a Ube2S-Ubiquitin Conjugate.

Lorenz S, Bhattacharyya M, Feiler C, Rape M, Kuriyan J.

PLoS One. 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550. eCollection 2016.

5.

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM.

J Exp Med. 2016 Feb 8;213(2):155-65. doi: 10.1084/jem.20150888. Epub 2016 Jan 18.

6.

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.

Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J.

Mol Cell Biol. 2015 Sep 1;35(17):3083-102. doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29.

7.

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Sjölin-Goodfellow H, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon AR, Weiss A.

Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596.

8.

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).

Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J.

PLoS One. 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177. eCollection 2015.

9.

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J.

Biochem J. 2015 Jun 1;468(2):283-91. doi: 10.1042/BJ20141492.

PMID:
25779001
10.

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J.

Elife. 2015 Feb 20;4. doi: 10.7554/eLife.06074.

11.

A structural perspective on the regulation of the epidermal growth factor receptor.

Kovacs E, Zorn JA, Huang Y, Barros T, Kuriyan J.

Annu Rev Biochem. 2015;84:739-64. doi: 10.1146/annurev-biochem-060614-034402. Epub 2015 Jan 26. Review.

12.

A structural atlas of kinases inhibited by clinically approved drugs.

Wang Q, Zorn JA, Kuriyan J.

Methods Enzymol. 2014;548:23-67. doi: 10.1016/B978-0-12-397918-6.00002-1. Review.

PMID:
25399641
13.

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J.

Biochem J. 2015 Jan 1;465(1):149-61. doi: 10.1042/BJ20140793.

14.

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.

Herzik MA Jr, Jonnalagadda R, Kuriyan J, Marletta MA.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4156-64. doi: 10.1073/pnas.1416936111. Epub 2014 Sep 24.

15.

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.

Endres NF, Barros T, Cantor AJ, Kuriyan J.

Trends Biochem Sci. 2014 Oct;39(10):437-46. doi: 10.1016/j.tibs.2014.08.001. Epub 2014 Sep 18. Review.

PMID:
25242369
16.

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT.

Science. 2014 Jul 4;345(6192):50-4. doi: 10.1126/science.1250373.

17.

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12.

18.

Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2014 Feb 11;3:e02490. doi: 10.7554/eLife.02490. No abstract available.

19.

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2013 Jan 1;3:e01610. doi: 10.7554/eLife.01610. Erratum in: Elife. 2014;3:e02490.

20.

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.

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