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Items: 1 to 20 of 169


Understanding the pathogenesis of abdominal aortic aneurysms.

Kuivaniemi H, Ryer EJ, Elmore JR, Tromp G.

Expert Rev Cardiovasc Ther. 2015 Sep;13(9):975-987.


Patients with familial abdominal aortic aneurysms are at increased risk for endoleak and secondary intervention following elective endovascular aneurysm repair.

Ryer EJ, Garvin RP, Thomas B, Kuivaniemi H, Franklin DP, Elmore JR.

J Vasc Surg. 2015 Aug 4. pii: S0741-5214(15)01452-4. doi: 10.1016/j.jvs.2015.06.205. [Epub ahead of print]


A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough.

Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM.

Pharmacogenomics J. 2015 Jul 14. doi: 10.1038/tpj.2015.51. [Epub ahead of print]


The potential role of DNA methylation in abdominal aortic aneurysms.

Ryer EJ, Ronning KE, Erdman R, Schworer CM, Elmore JR, Peeler TC, Nevius CD, Lillvis JH, Garvin RP, Franklin DP, Kuivaniemi H, Tromp G.

Int J Mol Sci. 2015 May 18;16(5):11259-75. doi: 10.3390/ijms160511259.


Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm.

Pahl MC, Erdman R, Kuivaniemi H, Lillvis JH, Elmore JR, Tromp G.

Int J Mol Sci. 2015 May 18;16(5):11229-58. doi: 10.3390/ijms160511229.


Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.

Hinterseher I, Schworer CM, Lillvis JH, Stahl E, Erdman R, Gatalica Z, Tromp G, Kuivaniemi H.

Int J Mol Sci. 2015 May 18;16(5):11196-212. doi: 10.3390/ijms160511196.


SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.

Dai X, Shen J, Annam NP, Jiang H, Levi E, Schworer CM, Tromp G, Arora A, Higgins M, Wang XF, Yang M, Li HJ, Zhang K, Kuivaniemi H, Li L.

Sci Rep. 2015 May 18;5:10180. doi: 10.1038/srep10180.


Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network.

Hall MA, Verma SS, Wallace J, Lucas A, Berg RL, Connolly J, Crawford DC, Crosslin DR, de Andrade M, Doheny KF, Haines JL, Harley JB, Jarvik GP, Kitchner T, Kuivaniemi H, Larson EB, Carrell DS, Tromp G, Vrabec TR, Pendergrass SA, McCarty CA, Ritchie MD.

Genet Epidemiol. 2015 Jul;39(5):376-84. doi: 10.1002/gepi.21902. Epub 2015 May 17.


The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research.

Ritchie MD, de Andrade M, Kuivaniemi H.

Front Genet. 2015 Mar 17;6:104. doi: 10.3389/fgene.2015.00104. eCollection 2015. No abstract available.


Imputation and quality control steps for combining multiple genome-wide datasets.

Verma SS, de Andrade M, Tromp G, Kuivaniemi H, Pugh E, Namjou-Khales B, Mukherjee S, Jarvik GP, Kottyan LC, Burt A, Bradford Y, Armstrong GD, Derr K, Crawford DC, Haines JL, Li R, Crosslin D, Ritchie MD.

Front Genet. 2014 Dec 11;5:370. doi: 10.3389/fgene.2014.00370. eCollection 2014.


Gene expression study in positron emission tomography-positive abdominal aortic aneurysms identifies CCL18 as a potential biomarker for rupture risk.

Courtois A, Nusgens BV, Hustinx R, Namur G, Gomez P, Kuivaniemi H, Defraigne JO, Colige AC, Sakalihasan N.

Mol Med. 2015 Mar 24;20:697-706. doi: 10.2119/molmed.2014.00065.


Population risk factor estimates for abdominal aortic aneurysm from electronic medical records: a case control study.

Smelser DT, Tromp G, Elmore JR, Kuivaniemi H, Franklin DP, Kirchner HL, Carey DJ.

BMC Cardiovasc Disord. 2014 Dec 4;14:174. doi: 10.1186/1471-2261-14-174.


Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records.

Crosslin DR, Tromp G, Burt A, Kim DS, Verma SS, Lucas AM, Bradford Y, Crawford DC, Armasu SM, Heit JA, Hayes MG, Kuivaniemi H, Ritchie MD, Jarvik GP, de Andrade M; electronic Medical Records and Genomics (eMERGE) Network.

Front Genet. 2014 Nov 4;5:352. doi: 10.3389/fgene.2014.00352. eCollection 2014.


Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model.

Cheng J, Koenig SN, Kuivaniemi HS, Garg V, Hans CP.

J Am Heart Assoc. 2014 Oct 27;3(6):e001064. doi: 10.1161/JAHA.114.001064.


Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.

Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman GJ, Sadee W.

Circ Res. 2014 Dec 5;115(12):1017-25. doi: 10.1161/CIRCRESAHA.116.304398. Epub 2014 Oct 17.


Genetic variation in the HLA region is associated with susceptibility to herpes zoster.

Crosslin DR, Carrell DS, Burt A, Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E, de Andrade M, Kullo IJ, Tromp G, Kuivaniemi H, Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E, Kho A, Pacheco J, Hayes MG, Ritchie MD, Verma SS, Armstrong G, Stallings S, Denny JC, Carroll RJ, Crawford DC, Crane PK, Mukherjee S, Bottinger E, Li R, Keating B, Mirel DB, Carlson CS, Harley JB, Larson EB, Jarvik GP.

Genes Immun. 2015 Jan-Feb;16(1):1-7. doi: 10.1038/gene.2014.51. Epub 2014 Oct 9.


Molecular basis and genetic predisposition to intracranial aneurysm.

Tromp G, Weinsheimer S, Ronkainen A, Kuivaniemi H.

Ann Med. 2014 Dec;46(8):597-606. doi: 10.3109/07853890.2014.949299. Epub 2014 Aug 12. Review.


Sex differences in abdominal aortic aneurysm: the role of sex hormones.

Makrygiannis G, Courtois A, Drion P, Defraigne JO, Kuivaniemi H, Sakalihasan N.

Ann Vasc Surg. 2014 Nov;28(8):1946-58. doi: 10.1016/j.avsg.2014.07.008. Epub 2014 Aug 6. Review.


Proinflammatory role of stem cells in abdominal aortic aneurysms.

Ryer EJ, Garvin RP, Schworer CM, Bernard-Eckroth KR, Tromp G, Franklin DP, Elmore JR, Kuivaniemi H.

J Vasc Surg. 2014 Jul 2. pii: S0741-5214(14)00934-3. doi: 10.1016/j.jvs.2014.04.067. [Epub ahead of print]


eMERGEing progress in genomics-the first seven years.

Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD.

Front Genet. 2014 Jun 17;5:184. doi: 10.3389/fgene.2014.00184. eCollection 2014. Review.

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