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Results: 1 to 20 of 30

1.

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses.

Ried JS, Shin SY, Krumsiek J, Illig T, Theis FJ, Spector TD, Adamski J, Wichmann HE, Strauch K, Soranzo N, Suhre K, Gieger C.

Hum Mol Genet. 2014 Jun 13. pii: ddu301. [Epub ahead of print]

PMID:
24927737
[PubMed - as supplied by publisher]
2.

An atlas of genetic influences on human blood metabolites.

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E; Multiple Tissue Human Expression Resource (MuTHER) Consortium, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenmüller G, Spector TD, Soranzo N.

Nat Genet. 2014 Jun;46(6):543-50. doi: 10.1038/ng.2982. Epub 2014 May 11.

PMID:
24816252
[PubMed - in process]
3.

Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study.

Floegel A, Wientzek A, Bachlechner U, Jacobs S, Drogan D, Prehn C, Adamski J, Krumsiek J, Schulze MB, Pischon T, Boeing H.

Int J Obes (Lond). 2014 Mar 10. doi: 10.1038/ijo.2014.39. [Epub ahead of print]

PMID:
24608922
[PubMed - as supplied by publisher]
4.

Metabolite profiling reveals new insights into the regulation of serum urate in humans.

Albrecht E, Waldenberger M, Krumsiek J, Evans AM, Jeratsch U, Breier M, Adamski J, Koenig W, Zeilinger S, Fuchs C, Klopp N, Theis FJ, Wichmann HE, Suhre K, Illig T, Strauch K, Peters A, Gieger C, Kastenmüller G, Doering A, Meisinger C.

Metabolomics. 2014;10:141-151. Epub 2013 Jul 20.

PMID:
24482632
[PubMed]
Free PMC Article
5.

A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.

Bonifacio E, Krumsiek J, Winkler C, Theis FJ, Ziegler AG.

Acta Diabetol. 2014 Jun;51(3):403-11. doi: 10.1007/s00592-013-0526-2. Epub 2013 Nov 19.

PMID:
24249616
[PubMed - in process]
6.

A study of Caenorhabditis elegans DAF-2 mutants by metabolomics and differential correlation networks.

Castro C, Krumsiek J, Lehrbach NJ, Murfitt SA, Miska EA, Griffin JL.

Mol Biosyst. 2013 Jul;9(7):1632-42. doi: 10.1039/c3mb25539e. Epub 2013 Mar 11.

PMID:
23475189
[PubMed - indexed for MEDLINE]
7.

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.

Ried JS, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann HE, Theis FJ, Illig T, Adamski J, Weidinger S.

Allergy. 2013;68(5):629-36. doi: 10.1111/all.12110. Epub 2013 Mar 1.

PMID:
23452035
[PubMed - indexed for MEDLINE]
8.

Statistical methods for the analysis of high-throughput metabolomics data.

Bartel J, Krumsiek J, Theis FJ.

Comput Struct Biotechnol J. 2013 Mar 22;4:e201301009. doi: 10.5936/csbj.201301009. eCollection 2013. Review.

PMID:
24688690
[PubMed]
Free PMC Article
9.

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RP, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM, Johansson A, Murgia F, Wild SH, Bakker SJ, Peden JF, Dehghan A, Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimäki T, Woodward OM, Okada Y, Tin A, Müller C, Oldmeadow C, Putku M, Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK, Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M, Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs DR Jr, Liu K, D'Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G, Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B, Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ, Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E, Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R, Döring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann HE, Davies G, Gow AJ, Bruinenberg M; LifeLines Cohort Study, Stolk RP, Kooner JS, Zhang W, Winkelmann BR, Boehm BO, Lucae S, Penninx BW, Smit JH, Curhan G, Mudgal P, Plenge RM, Portas L, Persico I, Kirin M, Wilson JF, Mateo Leach I, van Gilst WH, Goel A, Ongen H, Hofman A, Rivadeneira F, Uitterlinden AG, Imboden M, von Eckardstein A, Cucca F, Nagaraja R, Piras MG, Nauck M, Schurmann C, Budde K, Ernst F, Farrington SM, Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa V, Shin SY, Spector TD, Sala C, Ridker PM, Kähönen M, Viikari J, Hengstenberg C, Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium, Meschia JF, Nalls MA, Sharma P, Singleton AB, Kamatani N, Zeller T, Burnier M, Attia J, Laan M, Klopp N, Hillege HL, Kloiber S, Choi H, Pirastu M, Tore S, Probst-Hensch NM, Völzke H, Gudnason V, Parsa A, Schmidt R, Whitfield JB, Fornage M, Gasparini P, Siscovick DS, Polašek O, Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos RJ, van Duijn CM, Borecki IB, Ferrucci L, Gambaro G, Deary IJ, Wolffenbuttel BH, Chambers JC, März W, Pramstaller PP, Snieder H, Gyllensten U, Wright AF, Navis G, Watkins H, Witteman JC, Sanna S, Schipf S, Dunlop MG, Tönjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI, Raitakari O, Kao WH, Ciullo M, Fox CS, Caulfield M, Bochud M, Gieger C.

Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. Epub 2012 Dec 23.

PMID:
23263486
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality.

Altmaier E, Emeny RT, Krumsiek J, Lacruz ME, Lukaschek K, Häfner S, Kastenmüller G, Römisch-Margl W, Prehn C, Mohney RP, Evans AM, Milburn MV, Illig T, Adamski J, Theis F, Suhre K, Ladwig KH.

Psychoneuroendocrinology. 2013 Aug;38(8):1299-309. doi: 10.1016/j.psyneuen.2012.11.014. Epub 2012 Dec 10.

PMID:
23237813
[PubMed - indexed for MEDLINE]
11.

Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information.

Krumsiek J, Suhre K, Evans AM, Mitchell MW, Mohney RP, Milburn MV, Wägele B, Römisch-Margl W, Illig T, Adamski J, Gieger C, Theis FJ, Kastenmüller G.

PLoS Genet. 2012;8(10):e1003005. doi: 10.1371/journal.pgen.1003005. Epub 2012 Oct 18.

PMID:
23093944
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.

Winkler C, Krumsiek J, Lempainen J, Achenbach P, Grallert H, Giannopoulou E, Bunk M, Theis FJ, Bonifacio E, Ziegler AG.

Genes Immun. 2012 Oct;13(7):549-55. doi: 10.1038/gene.2012.36. Epub 2012 Aug 30.

PMID:
22932816
[PubMed - indexed for MEDLINE]
13.

Identification and quantification of 1-hydroxybutene-2-yl mercapturic acid in human urine by UPLC- HILIC-MS/MS as a novel biomarker for 1,3-butadiene exposure.

Sterz K, Scherer G, Krumsiek J, Theis FJ, Ecker J.

Chem Res Toxicol. 2012 Aug 20;25(8):1565-7. doi: 10.1021/tx3002862. Epub 2012 Jul 27.

PMID:
22817647
[PubMed - indexed for MEDLINE]
14.

Body fat free mass is associated with the serum metabolite profile in a population-based study.

Jourdan C, Petersen AK, Gieger C, Döring A, Illig T, Wang-Sattler R, Meisinger C, Peters A, Adamski J, Prehn C, Suhre K, Altmaier E, Kastenmüller G, Römisch-Margl W, Theis FJ, Krumsiek J, Wichmann HE, Linseisen J.

PLoS One. 2012;7(6):e40009. doi: 10.1371/journal.pone.0040009. Epub 2012 Jun 27.

PMID:
22761945
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Bayesian independent component analysis recovers pathway signatures from blood metabolomics data.

Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ.

J Proteome Res. 2012 Aug 3;11(8):4120-31. doi: 10.1021/pr300231n. Epub 2012 Jul 17.

PMID:
22713116
[PubMed - indexed for MEDLINE]
16.

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies.

Petersen AK, Krumsiek J, Wägele B, Theis FJ, Wichmann HE, Gieger C, Suhre K.

BMC Bioinformatics. 2012 Jun 6;13:120. doi: 10.1186/1471-2105-13-120.

PMID:
22672667
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The dynamic range of the human metabolome revealed by challenges.

Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, Sailer M, Raffler J, Römisch-Margl W, Adamski J, Prehn C, Frank T, Engel KH, Hofmann T, Luy B, Zimmermann R, Moritz F, Schmitt-Kopplin P, Krumsiek J, Kremer W, Huber F, Oeh U, Theis FJ, Szymczak W, Hauner H, Suhre K, Daniel H.

FASEB J. 2012 Jun;26(6):2607-19. doi: 10.1096/fj.11-198093. Epub 2012 Mar 16.

PMID:
22426117
[PubMed - indexed for MEDLINE]
Free Article
18.

Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network.

Krumsiek J, Marr C, Schroeder T, Theis FJ.

PLoS One. 2011;6(8):e22649. doi: 10.1371/journal.pone.0022649. Epub 2011 Aug 10.

PMID:
21853041
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Discovery of sexual dimorphisms in metabolic and genetic biomarkers.

Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T.

PLoS Genet. 2011 Aug;7(8):e1002215. doi: 10.1371/journal.pgen.1002215. Epub 2011 Aug 11.

PMID:
21852955
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.

Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ.

BMC Syst Biol. 2011 Jan 31;5:21. doi: 10.1186/1752-0509-5-21.

PMID:
21281499
[PubMed - indexed for MEDLINE]
Free PMC Article

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