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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.

Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M.

J Clin Invest. 2016 Apr 1;126(4):1603. doi: 10.1172/JCI87345. Epub 2016 Apr 1. No abstract available.


Biomarkers for monitoring pre-analytical quality variation of mRNA in blood samples.

Zhang H, Korenková V, Sjöback R, Švec D, Björkman J, Kruhøffer M, Verderio P, Pizzamiglio S, Ciniselli CM, Wyrich R, Oelmueller U, Kubista M, Lindahl T, Lönneborg A, Rian E.

PLoS One. 2014 Nov 4;9(11):e111644. doi: 10.1371/journal.pone.0111644. eCollection 2014.


miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan.

Schou JV, Rossi S, Jensen BV, Nielsen DL, Pfeiffer P, Høgdall E, Yilmaz M, Tejpar S, Delorenzi M, Kruhøffer M, Johansen JS.

PLoS One. 2014 Jun 18;9(6):e99886. doi: 10.1371/journal.pone.0099886. eCollection 2014.


Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue.

Hedegaard J, Thorsen K, Lund MK, Hein AM, Hamilton-Dutoit SJ, Vang S, Nordentoft I, Birkenkamp-Demtröder K, Kruhøffer M, Hager H, Knudsen B, Andersen CL, Sørensen KD, Pedersen JS, Ørntoft TF, Dyrskjøt L.

PLoS One. 2014 May 30;9(5):e98187. doi: 10.1371/journal.pone.0098187. eCollection 2014.


Data resource profile: the Aarhus birth cohort biobank (ABC biobank).

Mortensen LM, Bech BH, Nohr EA, Kruhøffer M, Kjærgaard S, Uldbjerg N, Olsen J, Henriksen TB.

Int J Epidemiol. 2013 Dec;42(6):1697-701. doi: 10.1093/ije/dyt199.


DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.

Pedersen JM, Fredsoe J, Roedgaard M, Andreasen L, Mundbjerg K, Kruhøffer M, Brinch M, Schierup MH, Bjergbaek L, Andersen AH.

PLoS Genet. 2012;8(12):e1003128. doi: 10.1371/journal.pgen.1003128. Epub 2012 Dec 20.


Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas.

Schultz NA, Roslind A, Christensen IJ, Horn T, Høgdall E, Pedersen LN, Kruhøffer M, Burcharth F, Wøjdemann M, Johansen JS.

Pancreas. 2012 Jul;41(5):759-66. doi: 10.1097/MPA.0b013e31823cd9df.


Ischemic pre- and postconditioning has pronounced effects on gene expression profiles in the rat liver after ischemia/reperfusion.

Knudsen AR, Kannerup AS, Dich R, Funch-Jensen P, Grønbaek H, Kruhøffer M, Mortensen FV.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G482-9. doi: 10.1152/ajpgi.00337.2011. Epub 2012 Jun 7.


Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer.

Bertini I, Cacciatore S, Jensen BV, Schou JV, Johansen JS, Kruhøffer M, Luchinat C, Nielsen DL, Turano P.

Cancer Res. 2012 Jan 1;72(1):356-64. doi: 10.1158/0008-5472.CAN-11-1543. Epub 2011 Nov 11.


Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.

Liaset B, Hao Q, Jørgensen H, Hallenborg P, Du ZY, Ma T, Marschall HU, Kruhøffer M, Li R, Li Q, Yde CC, Criales G, Bertram HC, Mellgren G, Ofjord ES, Lock EJ, Espe M, Frøyland L, Madsen L, Kristiansen K.

J Biol Chem. 2011 Aug 12;286(32):28382-95. doi: 10.1074/jbc.M111.234732. Epub 2011 Jun 16.


Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.

Baandrup JD, Markvardsen LH, Peters CD, Schou UK, Jensen JL, Magnusson NE, Ørntoft TF, Kruhøffer M, Simonsen U.

PLoS One. 2011 Jan 5;6(1):e15859. doi: 10.1371/journal.pone.0015859.


Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.

Neess D, Bloksgaard M, Bek S, Marcher AB, Elle IC, Helledie T, Due M, Pagmantidis V, Finsen B, Wilbertz J, Kruhøffer M, Færgeman N, Mandrup S.

J Biol Chem. 2011 Feb 4;286(5):3460-72. doi: 10.1074/jbc.M110.161109. Epub 2010 Nov 24.


Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males.

Marteau JB, Rigaud O, Brugat T, Gault N, Vallat L, Kruhoffer M, Orntoft TF, Nguyen-Khac F, Chevillard S, Merle-Beral H, Delic J.

BMC Med Genomics. 2010 Nov 10;3:53. doi: 10.1186/1755-8794-3-53.


Expression of genes involved in rat liver angiogenesis after ischaemia and reperfusion: effects of ischaemic pre- and post-conditioning.

Knudsen AR, Kannerup AS, Dich R, Kruhøffer M, Funch-Jensen P, Grønbaek H, Mortensen FV.

HPB (Oxford). 2010 Oct;12(8):554-60. doi: 10.1111/j.1477-2574.2010.00215.x.


1Identification of genes differentially expressed in the embryonic pig cerebral cortex before and after appearance of gyration.

Nielsen KB, Kruhøffer M, Holm IE, Jørgensen AL, Nielsen AL.

BMC Res Notes. 2010 May 5;3:127. doi: 10.1186/1756-0500-3-127.


Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.

Jorissen RN, Gibbs P, Christie M, Prakash S, Lipton L, Desai J, Kerr D, Aaltonen LA, Arango D, Kruhøffer M, Orntoft TF, Andersen CL, Gruidl M, Kamath VP, Eschrich S, Yeatman TJ, Sieber OM.

Clin Cancer Res. 2009 Dec 15;15(24):7642-7651. Epub .


IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.

Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T.

Eur Cytokine Netw. 2009 Jun;20(2):81-7. doi: 10.1684/ecn.2009.0152.


Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sørensen FB, Verspaget HW, Simon R, Kruhøffer M, Aaltonen LA, Laurberg S, Ørntoft TF.

Br J Cancer. 2009 Feb 10;100(3):511-23. doi: 10.1038/sj.bjc.6604884. Epub 2009 Jan 20.


Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.

Jensen SA, Vainer B, Kruhøffer M, Sørensen JB.

BMC Cancer. 2009 Jan 20;9:25. doi: 10.1186/1471-2407-9-25.


DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.

Jorissen RN, Lipton L, Gibbs P, Chapman M, Desai J, Jones IT, Yeatman TJ, East P, Tomlinson IP, Verspaget HW, Aaltonen LA, Kruhøffer M, Orntoft TF, Andersen CL, Sieber OM.

Clin Cancer Res. 2008 Dec 15;14(24):8061-9. doi: 10.1158/1078-0432.CCR-08-1431.

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