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Results: 1 to 20 of 60

1.

Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells.

Kiriazis A, Vahakoski RL, Santio NM, Arnaudova R, Eerola SK, Rainio EM, Aumüller IB, Yli-Kauhaluoma J, Koskinen PJ.

PLoS One. 2013;8(2):e55409. doi: 10.1371/journal.pone.0055409. Epub 2013 Feb 6.

PMID:
23405147
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R.

J Biol Chem. 2013 Feb 1;288(5):3048-58. doi: 10.1074/jbc.M112.361709. Epub 2012 Dec 3.

PMID:
23209281
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P, Ojala PM.

Oncogene. 2013 Feb 28;32(9):1091-8. doi: 10.1038/onc.2012.118. Epub 2012 Apr 2.

PMID:
22469985
[PubMed - indexed for MEDLINE]
4.

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Letribot B, Akué-Gédu R, Santio NM, El-Ghozzi M, Avignant D, Cisnetti F, Koskinen PJ, Gautier A, Anizon F, Moreau P.

Eur J Med Chem. 2012 Apr;50:304-10. doi: 10.1016/j.ejmech.2012.02.009. Epub 2012 Feb 10.

PMID:
22386260
[PubMed - indexed for MEDLINE]
5.

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion.

Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ.

Mol Cancer. 2010 Oct 19;9:279. doi: 10.1186/1476-4598-9-279.

PMID:
20958956
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

Peltola K, Hollmen M, Maula SM, Rainio E, Ristamäki R, Luukkaa M, Sandholm J, Sundvall M, Elenius K, Koskinen PJ, Grenman R, Jalkanen S.

Neoplasia. 2009 Jul;11(7):629-36.

PMID:
19568408
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM.

PLoS Pathog. 2009 Mar;5(3):e1000324. doi: 10.1371/journal.ppat.1000324. Epub 2009 Mar 6.

PMID:
19266083
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity.

Aho TL, Sandholm J, Peltola KJ, Ito Y, Koskinen PJ.

BMC Cell Biol. 2006 May 9;7:21.

PMID:
16684349
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation.

Aho TL, Lund RJ, Ylikoski EK, Matikainen S, Lahesmaa R, Koskinen PJ.

Immunology. 2005 Sep;116(1):82-8.

PMID:
16108820
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells.

Glazova M, Aho TL, Palmetshofer A, Murashov A, Scheinin M, Koskinen PJ.

Brain Res Mol Brain Res. 2005 Aug 18;138(2):116-23.

PMID:
15935514
[PubMed - indexed for MEDLINE]
11.

Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.

Rainio EM, Ahlfors H, Carter KL, Ruuska M, Matikainen S, Kieff E, Koskinen PJ.

Virology. 2005 Mar 15;333(2):201-6.

PMID:
15721354
[PubMed - indexed for MEDLINE]
Free Article
12.

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site.

Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ.

FEBS Lett. 2004 Jul 30;571(1-3):43-9.

PMID:
15280015
[PubMed - indexed for MEDLINE]
Free Article
13.

Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

Peltola KJ, Paukku K, Aho TL, Ruuska M, Silvennoinen O, Koskinen PJ.

Blood. 2004 May 15;103(10):3744-50. Epub 2004 Feb 5.

PMID:
14764533
[PubMed - indexed for MEDLINE]
Free Article
14.

Biochemical markers of types I and III collagen and limited joint mobility in type 1 diabetic patients.

Arkkila PE, Koskinen PJ, Kantola IM, Rönnemaa T, Seppänen E, Viikari JS.

Acta Diabetol. 2003 Dec;40(4):151-5.

PMID:
14740273
[PubMed - indexed for MEDLINE]
15.

Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1.

Thompson J, Peltola KJ, Koskinen PJ, Jänne OA, Palvimo JJ.

Lab Invest. 2003 Sep;83(9):1301-9.

PMID:
13679438
[PubMed - indexed for MEDLINE]
16.

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.

Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M.

J Biol Chem. 2003 Nov 14;278(46):45358-67. Epub 2003 Sep 3.

PMID:
12954615
[PubMed - indexed for MEDLINE]
Free Article
17.

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.

Rainio EM, Sandholm J, Koskinen PJ.

J Immunol. 2002 Feb 15;168(4):1524-7.

PMID:
11823475
[PubMed - indexed for MEDLINE]
Free Article
18.

Biochemical markers of type III and I collagen: association with retinopathy and neuropathy in type 1 diabetic subjects.

Arkkila PE, Rönnemaa T, Koskinen PJ, Kantola IM, Seppänen E, Viikari JS.

Diabet Med. 2001 Oct;18(10):816-21.

PMID:
11678972
[PubMed - indexed for MEDLINE]
19.

Diabetic complications are associated with liver enzyme activities in people with type 1 diabetes.

Arkkila PE, Koskinen PJ, Kantola IM, Rönnemaa T, Seppänen E, Viikari JS.

Diabetes Res Clin Pract. 2001 May;52(2):113-8.

PMID:
11311965
[PubMed - indexed for MEDLINE]
20.

Dupuytren's disease in type I diabetic subjects: investigation of biochemical markers of type III and I collagen.

Arkkila PE, Koskinen PJ, Kantola IM, Rönnemaa T, Seppänen E, Viikari JS.

Clin Exp Rheumatol. 2000 Mar-Apr;18(2):215-9.

PMID:
10812494
[PubMed - indexed for MEDLINE]

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