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Items: 1 to 20 of 226

1.

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Fey D, Halasz M, Dreidax D, Kennedy SP, Hastings JF, Rauch N, Munoz AG, Pilkington R, Fischer M, Westermann F, Kolch W, Kholodenko BN, Croucher DR.

Sci Signal. 2015 Dec 22;8(408):ra130. doi: 10.1126/scisignal.aab0990.

PMID:
26696630
2.

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma.

Duffy DJ, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, Mehta JP, Killick K, Whilde J, Turriziani B, Haapa-Paananen S, Fey V, Fischer M, Westermann F, Henrich KO, Bannert S, Higgins DG, Kolch W.

Oncotarget. 2015 Dec 22;6(41):43182-201. doi: 10.18632/oncotarget.6568.

3.

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

Jambrina PG, Rauch N, Pilkington R, Rybakova K, Nguyen LK, Kholodenko BN, Buchete NV, Kolch W, Rosta E.

Angew Chem Int Ed Engl. 2016 Jan;55(3):983-6. doi: 10.1002/anie.201509272. Epub 2015 Dec 8.

PMID:
26644280
4.

A microfluidic dual gradient generator for conducting cell-based drug combination assays.

Kilinc D, Schwab J, Rampini S, Ikpekha OW, Thampi A, Blasiak A, Li P, Schwamborn R, Kolch W, Matallanas D, Lee GU.

Integr Biol (Camb). 2016 Jan 18;8(1):39-49. doi: 10.1039/c5ib00209e. Epub 2015 Nov 16.

PMID:
26569638
5.

MST2-RASSF protein-protein interactions through SARAH domains.

Sánchez-Sanz G, Matallanas D, Nguyen LK, Kholodenko BN, Rosta E, Kolch W, Buchete NV.

Brief Bioinform. 2015 Oct 5. pii: bbv070. [Epub ahead of print]

PMID:
26443615
6.

Measuring Transcription Rate Changes via Time-Course 4-Thiouridine Pulse-Labelling Improves Transcriptional Target Identification.

Schwarzl T, Higgins DG, Kolch W, Duffy DJ.

J Mol Biol. 2015 Oct 23;427(21):3368-74. doi: 10.1016/j.jmb.2015.09.006. Epub 2015 Sep 9.

PMID:
26362006
7.

The dynamic control of signal transduction networks in cancer cells.

Kolch W, Halasz M, Granovskaya M, Kholodenko BN.

Nat Rev Cancer. 2015 Sep;15(9):515-27. doi: 10.1038/nrc3983. Epub 2015 Aug 20. Review.

PMID:
26289315
8.

Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses.

Varusai TM, Kolch W, Kholodenko BN, Nguyen LK.

Mol Biosyst. 2015 Oct;11(10):2750-62. doi: 10.1039/c5mb00385g.

PMID:
26266875
9.

ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells.

Ryan CM, Brown JA, Bourke E, Prendergast ÁM, Kavanagh C, Liu Z, Owens P, Shaw G, Kolch W, O'Brien T, Barry FP.

Stem Cell Res Ther. 2015 Jul 24;6:136. doi: 10.1186/s13287-015-0125-y.

10.

Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.

Milewska M, Romano D, Herrero A, Guerriero ML, Birtwistle M, Quehenberger F, Hatzl S, Kholodenko BN, Segatto O, Kolch W, Zebisch A.

PLoS One. 2015 Jun 12;10(6):e0129859. doi: 10.1371/journal.pone.0129859. eCollection 2015.

11.

Silence on the relevant literature and errors in implementation.

Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff HV, Kholodenko BN.

Nat Biotechnol. 2015 Apr;33(4):336-9. doi: 10.1038/nbt.3185. No abstract available.

PMID:
25850052
12.

Network-based identification of feedback modules that control RhoA activity and cell migration.

Kim TH, Monsefi N, Song JH, von Kriegsheim A, Vandamme D, Pertz O, Kholodenko BN, Kolch W, Cho KH.

J Mol Cell Biol. 2015 Jun;7(3):242-52. doi: 10.1093/jmcb/mjv017. Epub 2015 Mar 16.

13.

Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.

Tortolina L, Duffy DJ, Maffei M, Castagnino N, Carmody AM, Kolch W, Kholodenko BN, De Ambrosi C, Barla A, Biganzoli EM, Nencioni A, Patrone F, Ballestrero A, Zoppoli G, Verri A, Parodi S.

Oncotarget. 2015 Mar 10;6(7):5041-58.

14.

Signalling mechanisms regulating phenotypic changes in breast cancer cells.

Volinsky N, McCarthy CJ, von Kriegsheim A, Saban N, Okada-Hatakeyama M, Kolch W, Kholodenko BN.

Biosci Rep. 2015 Mar 18;35(2). pii: e00178. doi: 10.1042/BSR20140172.

15.

Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.

Nguyen LK, Matallanas DG, Romano D, Kholodenko BN, Kolch W.

Cell Cycle. 2015;14(2):189-99. doi: 10.4161/15384101.2014.973743.

16.

Regulation of the MAPK pathway by raf kinase inhibitory protein.

Vandamme D, Herrero A, Al-Mulla F, Kolch W.

Crit Rev Oncog. 2014;19(6):405-15. Review.

PMID:
25597351
17.

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

Kilinc D, Lesniak A, Rashdan SA, Gandhi D, Blasiak A, Fannin PC, von Kriegsheim A, Kolch W, Lee GU.

Adv Healthc Mater. 2015 Feb 18;4(3):395-404. doi: 10.1002/adhm.201400391. Epub 2014 Oct 9.

PMID:
25296863
18.

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells.

Lesniak A, Kilinc D, Rashdan SA, von Kriegsheim A, Ashall B, Zerulla D, Kolch W, Lee GU.

Faraday Discuss. 2014;175:189-201. doi: 10.1039/c4fd00115j.

PMID:
25266763
19.

One Hippo and many masters: differential regulation of the Hippo pathway in cancer.

Romano D, Matallanas D, Frederick DT, Flaherty KT, Kolch W.

Biochem Soc Trans. 2014 Aug;42(4):816-21. doi: 10.1042/BST20140030. Review.

PMID:
25109963
20.

Molecular mechanisms of asymmetric RAF dimer activation.

Jambrina PG, Bohuszewicz O, Buchete NV, Kolch W, Rosta E.

Biochem Soc Trans. 2014 Aug;42(4):784-90. doi: 10.1042/BST20140025. Review.

PMID:
25109958
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