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Items: 1 to 20 of 24

1.

N-Acylethanolamines Bind to SIRT6.

Rahnasto-Rilla M, Kokkola T, Jarho E, Lahtela-Kakkonen M, Moaddel R.

Chembiochem. 2016 Jan;17(1):77-81. doi: 10.1002/cbic.201500482. Epub 2015 Nov 26.

PMID:
26607666
2.

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.

Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ.

Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2.

PMID:
26575458
3.

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.

Yaluri N, Modi S, López Rodríguez M, Stančáková A, Kuusisto J, Kokkola T, Laakso M.

PLoS One. 2015 Nov 11;10(11):e0142902. doi: 10.1371/journal.pone.0142902. eCollection 2015.

4.

Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment.

Pesonen M, Storvik M, Kokkola T, Rysä J, Vähäkangas K, Pasanen M.

Chem Res Toxicol. 2015 Oct 19;28(10):1926-35. doi: 10.1021/acs.chemrestox.5b00123. Epub 2015 Sep 17.

PMID:
26352163
5.

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses.

Kokkola T, Suuronen T, Pesonen M, Filippakopoulos P, Salminen A, Jarho EM, Lahtela-Kakkonen M.

Chembiochem. 2015 Sep 21;16(14):1997-2001. doi: 10.1002/cbic.201500272. Epub 2015 Aug 13.

6.

Virtual screening approach of sirtuin inhibitors results in two new scaffolds.

Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela-Kakkonen M.

Eur J Pharm Sci. 2015 Aug 30;76:27-32. doi: 10.1016/j.ejps.2015.04.025. Epub 2015 May 1.

PMID:
25936698
7.

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress.

Oksala NK, Ekmekçi FG, Ozsoy E, Kirankaya S, Kokkola T, Emecen G, Lappalainen J, Kaarniranta K, Atalay M.

Redox Biol. 2014;3:25-8. doi: 10.1016/j.redox.2014.10.003. Epub 2014 Oct 24.

8.

Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.

Seifert T, Malo M, Kokkola T, Engen K, Fridén-Saxin M, Wallén EA, Lahtela-Kakkonen M, Jarho EM, Luthman K.

J Med Chem. 2014 Dec 11;57(23):9870-88. doi: 10.1021/jm500930h. Epub 2014 Dec 2.

PMID:
25383691
9.

Studying SIRT6 regulation using H3K56 based substrate and small molecules.

Kokkonen P, Rahnasto-Rilla M, Mellini P, Jarho E, Lahtela-Kakkonen M, Kokkola T.

Eur J Pharm Sci. 2014 Oct 15;63:71-6. doi: 10.1016/j.ejps.2014.06.015. Epub 2014 Jul 6.

PMID:
25004411
10.

AROS has a context-dependent effect on SIRT1.

Kokkola T, Suuronen T, Molnár F, Määttä J, Salminen A, Jarho EM, Lahtela-Kakkonen M.

FEBS Lett. 2014 May 2;588(9):1523-8. doi: 10.1016/j.febslet.2014.03.020. Epub 2014 Mar 26.

11.

Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.

Mellini P, Kokkola T, Suuronen T, Salo HS, Tolvanen L, Mai A, Lahtela-Kakkonen M, Jarho EM.

J Med Chem. 2013 Sep 12;56(17):6681-95. doi: 10.1021/jm400438k. Epub 2013 Aug 22.

PMID:
23927550
12.

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.

Kokkola T, Kruse C, Roy-Pogodzik EM, Pekkinen J, Bauch C, Hönck HH, Hennemann H, Kreienkamp HJ.

FEBS Lett. 2011 Sep 2;585(17):2665-70. doi: 10.1016/j.febslet.2011.07.028. Epub 2011 Jul 31.

13.

Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity.

Atalay M, Bilginoglu A, Kokkola T, Oksala N, Turan B.

Mol Cell Biochem. 2011 May;351(1-2):125-31. doi: 10.1007/s11010-011-0719-3. Epub 2011 Jan 19.

PMID:
21246260
14.

An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples.

Breusing N, Grune T, Andrisic L, Atalay M, Bartosz G, Biasi F, Borovic S, Bravo L, Casals I, Casillas R, Dinischiotu A, Drzewinska J, Faber H, Fauzi NM, Gajewska A, Gambini J, Gradinaru D, Kokkola T, Lojek A, Luczaj W, Margina D, Mascia C, Mateos R, Meinitzer A, Mitjavila MT, Mrakovcic L, Munteanu MC, Podborska M, Poli G, Sicinska P, Skrzydlewska E, Vina J, Wiswedel I, Zarkovic N, Zelzer S, Spickett CM.

Free Radic Res. 2010 Oct;44(10):1203-15. doi: 10.3109/10715762.2010.499907.

PMID:
20836662
15.
16.

The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor.

Kokkola T, Salo OM, Poso A, Laitinen JT.

J Pineal Res. 2005 Aug;39(1):1-11.

PMID:
15978051
17.

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.

Savinainen JR, Kokkola T, Salo OM, Poso A, Järvinen T, Laitinen JT.

Br J Pharmacol. 2005 Jul;145(5):636-45.

18.

S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.

Kokkola T, Savinainen JR, Mönkkönen KS, Retamal MD, Laitinen JT.

BMC Cell Biol. 2005 Apr 25;6(1):21.

19.

Important amino acids for the function of the human MT1 melatonin receptor.

Kokkola T, Foord SM, Watson MA, Vakkuri O, Laitinen JT.

Biochem Pharmacol. 2003 May 1;65(9):1463-71.

PMID:
12732358
20.

Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function.

Kokkola T, Watson MA, White J, Dowell S, Foord SM, Laitinen JT.

Biochem Biophys Res Commun. 1998 Aug 19;249(2):531-6.

PMID:
9712731
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