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Items: 1 to 20 of 36


Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.

Crawford DJ, Liu MY, Nabel CS, Cao XJ, Garcia BA, Kohli RM.

J Am Chem Soc. 2016 Jan 27;138(3):730-3. doi: 10.1021/jacs.5b10554. Epub 2016 Jan 13.


Targets for Combating the Evolution of Acquired Antibiotic Resistance.

Culyba MJ, Mo CY, Kohli RM.

Biochemistry. 2015 Jun 16;54(23):3573-82. doi: 10.1021/acs.biochem.5b00109. Epub 2015 Jun 5. Review.


High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.

Gajula KS, Huwe PJ, Mo CY, Crawford DJ, Stivers JT, Radhakrishnan R, Kohli RM.

Nucleic Acids Res. 2014 Sep;42(15):9964-75. doi: 10.1093/nar/gku689. Epub 2014 Jul 26.


Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.

Stavrou S, Crawford D, Blouch K, Browne EP, Kohli RM, Ross SR.

PLoS Pathog. 2014 May 22;10(5):e1004145. doi: 10.1371/journal.ppat.1004145. eCollection 2014 May.


Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis.

Mo CY, Birdwell LD, Kohli RM.

Biochemistry. 2014 May 20;53(19):3158-68. doi: 10.1021/bi500026e. Epub 2014 May 8.


Molecular targeting of mutagenic AID and APOBEC deaminases.

Nabel CS, Schutsky EK, Kohli RM.

Cell Cycle. 2014;13(2):171-2. doi: 10.4161/cc.27036. Epub 2013 Nov 15. No abstract available.


TET enzymes, TDG and the dynamics of DNA demethylation.

Kohli RM, Zhang Y.

Nature. 2013 Oct 24;502(7472):472-9. doi: 10.1038/nature12750. Review.


Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.

Nabel CS, Lee JW, Wang LC, Kohli RM.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14225-30. doi: 10.1073/pnas.1306345110. Epub 2013 Aug 13.


APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.

MacMillan AL, Kohli RM, Ross SR.

J Virol. 2013 May;87(9):4808-17. doi: 10.1128/JVI.00112-13. Epub 2013 Feb 28.


AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

Nabel CS, Jia H, Ye Y, Shen L, Goldschmidt HL, Stivers JT, Zhang Y, Kohli RM.

Nat Chem Biol. 2012 Sep;8(9):751-8. doi: 10.1038/nchembio.1042. Epub 2012 Jul 8.


The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

Nabel CS, Manning SA, Kohli RM.

ACS Chem Biol. 2012 Jan 20;7(1):20-30. doi: 10.1021/cb2002895. Epub 2011 Oct 31. Review.


Molecular biology. Demystifying DNA demethylation.

Nabel CS, Kohli RM.

Science. 2011 Sep 2;333(6047):1229-30. doi: 10.1126/science.1211917. No abstract available.


Grand challenge commentary: The chemistry of a dynamic genome.

Kohli RM.

Nat Chem Biol. 2010 Dec;6(12):866-8. doi: 10.1038/nchembio.471.


Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

Kohli RM, Maul RW, Guminski AF, McClure RL, Gajula KS, Saribasak H, McMahon MA, Siliciano RF, Gearhart PJ, Stivers JT.

J Biol Chem. 2010 Dec 24;285(52):40956-64. doi: 10.1074/jbc.M110.177402. Epub 2010 Oct 6.


Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.

McMahon MA, Siliciano JD, Kohli RM, Siliciano RF.

AIDS. 2010 Jan 16;24(2):319-23. doi: 10.1097/QAD.0b013e32833424e5.


A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT.

J Biol Chem. 2009 Aug 21;284(34):22898-904. doi: 10.1074/jbc.M109.025536. Epub 2009 Jun 26.


When to think of zebras.

Ho RS, Kohli RM, Maragakis LL.

Am J Med. 2009 May;122(5):424-6. doi: 10.1016/j.amjmed.2009.01.008. No abstract available.


The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation.

McMahon MA, Siliciano JD, Lai J, Liu JO, Stivers JT, Siliciano RF, Kohli RM.

J Biol Chem. 2008 Nov 14;283(46):31289-93. doi: 10.1074/jbc.C800188200. Epub 2008 Sep 24.


Modification of medical outcome study (MOS) instrument for quality of life assessment & its validation in HIV infected individuals in India.

Kohli RM, Sane S, Kumar K, Paranjape RS, Mehendale SM.

Indian J Med Res. 2005 Oct;122(4):297-304.


Assessment of quality of life among HIV-infected persons in Pune, India.

Kohli RM, Sane S, Kumar K, Paranjape RS, Mehendale SM.

Qual Life Res. 2005 Aug;14(6):1641-7.

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