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Results: 1 to 20 of 25

1.

Bioinformatic analysis of 302 reactive metabolite target proteins. Which ones are important for cell death?

Hanzlik RP, Koen YM, Fang J.

Toxicol Sci. 2013 Oct;135(2):390-401. doi: 10.1093/toxsci/kft166. Epub 2013 Jul 28.

PMID:
23897987
[PubMed - indexed for MEDLINE]
2.

Protein targets of thioacetamide metabolites in rat hepatocytes.

Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2013 Apr 15;26(4):564-74. doi: 10.1021/tx400001x. Epub 2013 Mar 20.

PMID:
23465048
[PubMed - in process]
Free PMC Article
3.

Liver protein targets of hepatotoxic 4-bromophenol metabolites.

Koen YM, Hajovsky H, Liu K, Williams TD, Galeva NA, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Aug 20;25(8):1777-86. doi: 10.1021/tx3002675. Epub 2012 Aug 3.

PMID:
22827705
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

Sarma D, Hajovsky H, Koen YM, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1868-77. doi: 10.1021/tx3001658. Epub 2012 Jun 15.

PMID:
22667464
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.

Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP.

Chem Res Toxicol. 2012 May 21;25(5):1145-54. doi: 10.1021/tx300103j. Epub 2012 Apr 10.

PMID:
22462724
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

Fang J, Koen YM, Hanzlik RP.

BMC Chem Biol. 2009 Jun 12;9:5. doi: 10.1186/1472-6769-9-5.

PMID:
19523227
[PubMed]
Free PMC Article
7.

Filling and mining the reactive metabolite target protein database.

Hanzlik RP, Fang J, Koen YM.

Chem Biol Interact. 2009 Apr 15;179(1):38-44. doi: 10.1016/j.cbi.2008.08.016. Epub 2008 Sep 6. Review.

PMID:
18823962
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.

Ikehata K, Duzhak TG, Galeva NA, Ji T, Koen YM, Hanzlik RP.

Chem Res Toxicol. 2008 Jul;21(7):1432-42. doi: 10.1021/tx800093k. Epub 2008 Jun 12.

PMID:
18547066
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.

Ji T, Ikehata K, Koen YM, Esch SW, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2007 Apr;20(4):701-8. Epub 2007 Mar 24.

PMID:
17381136
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The reactive metabolite target protein database (TPDB)--a web-accessible resource.

Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J.

BMC Bioinformatics. 2007 Mar 16;8:95.

PMID:
17367530
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.

Koen YM, Gogichaeva NV, Alterman MA, Hanzlik RP.

Chem Res Toxicol. 2007 Mar;20(3):511-9. Epub 2007 Feb 17.

PMID:
17305373
[PubMed - indexed for MEDLINE]
12.

Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo.

Koen YM, Yue W, Galeva NA, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2006 Nov;19(11):1426-34.

PMID:
17112229
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Use of isotopic signatures for mass spectral detection of protein adduction by chemically reactive metabolites of bromobenzene: studies with model proteins.

Yue W, Koen YM, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2005 Nov;18(11):1748-54.

PMID:
16300384
[PubMed - indexed for MEDLINE]
14.

1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard.

Lucas LH, Cerny MA, Koen YM, Hanzlik RP, Larive CK.

Anal Bioanal Chem. 2004 Oct;380(4):627-31. Epub 2004 Oct 7.

PMID:
15480583
[PubMed - indexed for MEDLINE]
15.

Synthesis of N tau-arylhistidine derivatives via direct N-arylation.

Yue W, Lewis SI, Koen YM, Hanzlik RP.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1637-40.

PMID:
15026040
[PubMed - indexed for MEDLINE]
16.

Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.

Shaffer CL, Harriman S, Koen YM, Hanzlik RP.

J Am Chem Soc. 2002 Jul 17;124(28):8268-74.

PMID:
12105905
[PubMed - indexed for MEDLINE]
17.

Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene.

Koen YM, Hanzlik RP.

Chem Res Toxicol. 2002 May;15(5):699-706.

PMID:
12018992
[PubMed - indexed for MEDLINE]
18.

Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol.

Koen YM, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2000 Dec;13(12):1326-35.

PMID:
11123975
[PubMed - indexed for MEDLINE]
19.

Interactions of cytochrome P450 2B4 with NADPH-cytochrome P450 reductase studied by fluorescent probe.

Davydov DR, Knyushko TV, Kanaeva IP, Koen YM, Samenkova NF, Archakov AI, Hui Bon Hoa G.

Biochimie. 1996;78(8-9):734-43.

PMID:
9010602
[PubMed - indexed for MEDLINE]
20.

High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

Davydov DR, Deprez E, Hoa GH, Knyushko TV, Kuznetsova GP, Koen YM, Archakov AI.

Arch Biochem Biophys. 1995 Jul 10;320(2):330-44.

PMID:
7625841
[PubMed - indexed for MEDLINE]

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