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Results: 1 to 20 of 45

1.

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.

Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP.

Nat Immunol. 2015 Jul 27. doi: 10.1038/ni.3230. [Epub ahead of print]

PMID:
26214742
2.

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.

Albert GI, Schell C, Kirschner KM, Schäfer S, Naumann R, Müller A, Kretz O, Kuropka B, Girbig M, Hübner N, Krause E, Scholz H, Huber TB, Knobeloch KP, Freund C.

J Mol Cell Biol. 2015 Jun 16. pii: mjv039. [Epub ahead of print]

3.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M.

EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20.

PMID:
25896511
4.

ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo.

Ketscher L, Knobeloch KP.

Cytokine. 2015 Mar 21. pii: S1043-4666(15)00112-X. doi: 10.1016/j.cyto.2015.03.006. [Epub ahead of print]

PMID:
25805508
5.

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.

PMID:
25605921
6.

Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.

Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A.

Circulation. 2014 Oct 28;130(18):1589-600. doi: 10.1161/CIRCULATIONAHA.114.009847. Epub 2014 Aug 27.

PMID:
25165091
7.

Genetic targeting of microglia.

Wieghofer P, Knobeloch KP, Prinz M.

Glia. 2015 Jan;63(1):1-22. doi: 10.1002/glia.22727. Epub 2014 Aug 8.

PMID:
25132502
8.

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.

Basters A, Geurink PP, El Oualid F, Ketscher L, Casutt MS, Krause E, Ovaa H, Knobeloch KP, Fritz G.

FEBS J. 2014 Apr;281(7):1918-28. doi: 10.1111/febs.12754. Epub 2014 Mar 3.

PMID:
24533902
9.

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.

Begitt A, Droescher M, Meyer T, Schmid CD, Baker M, Antunes F, Knobeloch KP, Owen MR, Naumann R, Decker T, Vinkemeier U.

Nat Immunol. 2014 Feb;15(2):168-76. doi: 10.1038/ni.2794. Epub 2014 Jan 12. Erratum in: Nat Immunol. 2014 Nov;15(11):1090.

PMID:
24413774
10.

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia.

Troilo A, Alexander I, Muehl S, Jaramillo D, Knobeloch KP, Krek W.

EMBO Rep. 2014 Jan;15(1):77-85. doi: 10.1002/embr.201337688. Epub 2013 Dec 30.

11.

ISG15 regulates peritoneal macrophages functionality against viral infection.

Yángüez E, García-Culebras A, Frau A, Llompart C, Knobeloch KP, Gutierrez-Erlandsson S, García-Sastre A, Esteban M, Nieto A, Guerra S.

PLoS Pathog. 2013;9(10):e1003632. doi: 10.1371/journal.ppat.1003632. Epub 2013 Oct 10. Erratum in: PLoS Pathog. 2013 Oct;9(10). doi: 10.1371/annotation/64a20cef-bf55-4d84-983e-b914eb09b1ee.

12.

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.

13.

Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system.

Prinz M, Knobeloch KP.

Front Immunol. 2012 Apr 9;3:67. doi: 10.3389/fimmu.2012.00067. eCollection 2012.

14.

mHERC6 is the essential ISG15 E3 ligase in the murine system.

Ketscher L, Basters A, Prinz M, Knobeloch KP.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40. doi: 10.1016/j.bbrc.2011.11.071. Epub 2011 Nov 23.

PMID:
22138649
15.

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.

Nat Neurosci. 2011 Dec 4;15(1):98-106. doi: 10.1038/nn.2964.

PMID:
22138643
16.

ISG15 modulates development of the erythroid lineage.

Maragno AL, Pironin M, Alcalde H, Cong X, Knobeloch KP, Tangy F, Zhang DE, Ghysdael J, Quang CT.

PLoS One. 2011;6(10):e26068. doi: 10.1371/journal.pone.0026068. Epub 2011 Oct 12.

17.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

Begitt A, Droescher M, Knobeloch KP, Vinkemeier U.

Blood. 2011 Jul 28;118(4):1002-7. doi: 10.1182/blood-2011-04-347930. Epub 2011 Jun 2.

18.

Control of bone formation by the serpentine receptor Frizzled-9.

Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T.

J Cell Biol. 2011 Mar 21;192(6):1057-72. doi: 10.1083/jcb.201008012. Epub 2011 Mar 14.

19.

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.

Raasch J, Zeller N, van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, Del Turco D, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M.

Brain. 2011 Apr;134(Pt 4):1184-98. doi: 10.1093/brain/awq359. Epub 2011 Feb 10.

20.

In vivo functions of isgylation.

Knobeloch KP.

Subcell Biochem. 2010;54:215-27. doi: 10.1007/978-1-4419-6676-6_17.

PMID:
21222285
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