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Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T.

EMBO Mol Med. 2015 Aug 18;7(10):1285-306. doi: 10.15252/emmm.201505444.


Might your respiratory patient have alpha-1 antitrypsin deficiency?

Sandhaus RA, Knebel AR.

Heart Lung. 2015 Nov-Dec;44(6):463-4. doi: 10.1016/j.hrtlng.2015.07.003. Epub 2015 Aug 8. No abstract available.


Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H.

EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7.


Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.


Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.


Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.

Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW.

Nat Commun. 2015 Apr 24;6:6718. doi: 10.1038/ncomms7718.


Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes.

Stanley M, Han C, Knebel A, Murphy P, Shpiro N, Virdee S.

ACS Chem Biol. 2015 Jun 19;10(6):1542-54. doi: 10.1021/acschembio.5b00118. Epub 2015 Apr 15.


Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

Bulatov E, Martin EM, Chatterjee S, Knebel A, Shimamura S, Konijnenberg A, Johnson C, Zinn N, Grandi P, Sobott F, Ciulli A.

J Biol Chem. 2015 Feb 13;290(7):4178-91. doi: 10.1074/jbc.M114.616664. Epub 2014 Dec 11.


Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers.

Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT.

Biochem J. 2015 Mar 15;466(3):489-98. doi: 10.1042/BJ20141349.


Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.

Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M.

Nat Commun. 2014 Aug 27;5:4763. doi: 10.1038/ncomms5763.


Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM.

Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334.


How is emotional awareness related to emotion regulation strategies and self-reported negative affect in the general population?

Subic-Wrana C, Beutel ME, Brähler E, Stöbel-Richter Y, Knebel A, Lane RD, Wiltink J.

PLoS One. 2014 Mar 17;9(3):e91846. doi: 10.1371/journal.pone.0091846. eCollection 2014.


Informing the gestalt: an ethical framework for allocating scarce federal public health and medical resources to states during disasters.

Knebel AR, Sharpe VA, Danis M, Toomey LM, Knickerbocker DK.

Disaster Med Public Health Prep. 2014 Feb;8(1):79-88. doi: 10.1017/dmp.2014.9. Epub 2014 Mar 10.


Altered orientation of spatial attention in depersonalization disorder.

Adler J, Beutel ME, Knebel A, Berti S, Unterrainer J, Michal M.

Psychiatry Res. 2014 May 15;216(2):230-5. doi: 10.1016/j.psychres.2014.02.021. Epub 2014 Feb 19.


TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF.

EMBO J. 2013 Oct 30;32(21):2848-60. doi: 10.1038/emboj.2013.209. Epub 2013 Sep 27.


Implementing panic-focused psychodynamic psychotherapy into clinical practice.

Beutel ME, Scheurich V, Knebel A, Michal M, Wiltink J, Graf-Morgenstern M, Tschan R, Milrod B, Wellek S, Subic-Wrana C.

Can J Psychiatry. 2013 Jun;58(6):326-34.


CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.

Zemla A, Thomas Y, Kedziora S, Knebel A, Wood NT, Rabut G, Kurz T.

Nat Commun. 2013;4:1641. doi: 10.1038/ncomms2628.


Systematic review of strategies to manage and allocate scarce resources during mass casualty events.

Timbie JW, Ringel JS, Fox DS, Pillemer F, Waxman DA, Moore M, Hansen CK, Knebel AR, Ricciardi R, Kellermann AL.

Ann Emerg Med. 2013 Jun;61(6):677-689.e101. doi: 10.1016/j.annemergmed.2013.02.005. Epub 2013 Mar 20. Review.


The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.

Strickson S, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N, Cohen P.

Biochem J. 2013 May 1;451(3):427-37. doi: 10.1042/BJ20121651.


The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

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