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Results: 1 to 20 of 132

1.

Circulating FGF21 is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding.

Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ.

Diabetes. 2014 Jul 9. pii: DB_140595. [Epub ahead of print]

PMID:
25008183
[PubMed - as supplied by publisher]
2.

Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Epub 2013 Dec 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.

PMID:
24379397
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA.

Nat Med. 2013 Sep;19(9):1147-52. doi: 10.1038/nm.3249. Epub 2013 Aug 11.

PMID:
23933984
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

FGF21 contributes to neuroendocrine control of female reproduction.

Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ.

Nat Med. 2013 Sep;19(9):1153-6. doi: 10.1038/nm.3250. Epub 2013 Aug 11.

PMID:
23933983
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.

Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2013 Apr;27(4):598-605. doi: 10.1210/me.2012-1371. Epub 2013 Mar 15.

PMID:
23504956
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor.

Nelson BT, Ding X, Boney-Montoya J, Gerard RD, Kliewer SA, Andrews MT.

PLoS One. 2013;8(1):e53574. doi: 10.1371/journal.pone.0053574. Epub 2013 Jan 2.

PMID:
23301087
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G371-80. doi: 10.1152/ajpgi.00400.2012. Epub 2012 Dec 20.

PMID:
23257920
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ.

Elife (Cambridge). 2012 Oct 15;1:e00065. doi: 10.7554/eLife.00065.

PMID:
23066506
[PubMed]
Free PMC Article
9.

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.

Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ.

J Biol Chem. 2012 Nov 30;287(49):41334-41. doi: 10.1074/jbc.M112.421834. Epub 2012 Oct 4.

PMID:
23038264
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.

Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2012 Sep 5;16(3):387-93. doi: 10.1016/j.cmet.2012.08.002.

PMID:
22958921
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR, Kliewer SA, Mangelsdorf DJ, Schulman IG.

J Clin Invest. 2012 May 1;122(5):1688-99. doi: 10.1172/JCI59817. Epub 2012 Apr 9.

PMID:
22484817
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3143-8. doi: 10.1073/pnas.1200797109. Epub 2012 Feb 6.

PMID:
22315431
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA.

Cell. 2012 Feb 3;148(3):556-67. doi: 10.1016/j.cell.2011.11.062.

PMID:
22304921
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.

Potthoff MJ, Kliewer SA, Mangelsdorf DJ.

Genes Dev. 2012 Feb 15;26(4):312-24. doi: 10.1101/gad.184788.111. Epub 2012 Feb 2. Review.

PMID:
22302876
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.

Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE.

J Biol Chem. 2012 Feb 10;287(7):4894-903. doi: 10.1074/jbc.M111.315242. Epub 2011 Dec 14.

PMID:
22170062
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ.

Genes Dev. 2011 Aug 15;25(16):1674-9. doi: 10.1101/gad.16860911.

PMID:
21852532
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Roles of FGF19 in liver metabolism.

Kir S, Kliewer SA, Mangelsdorf DJ.

Cold Spring Harb Symp Quant Biol. 2011;76:139-44. doi: 10.1101/sqb.2011.76.010710. Epub 2011 Aug 3. Review.

PMID:
21813638
[PubMed - indexed for MEDLINE]
18.

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2011 Jun 8;13(6):729-38. doi: 10.1016/j.cmet.2011.03.019.

PMID:
21641554
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2011 Jun;25(6):1066-71. doi: 10.1210/me.2010-0460. Epub 2011 Mar 31.

PMID:
21454404
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ.

Science. 2011 Mar 25;331(6024):1621-4. doi: 10.1126/science.1198363.

PMID:
21436455
[PubMed - indexed for MEDLINE]
Free PMC Article

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