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Results: 1 to 20 of 108

1.
2.

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice.

van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PP, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DP, Heeringa P.

Aging (Albany NY). 2015 Apr;7(4):256-68.

3.

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology.

Liang W, Menke AL, Driessen A, Koek GH, Lindeman JH, Stoop R, Havekes LM, Kleemann R, van den Hoek AM.

PLoS One. 2014 Dec 23;9(12):e115922. doi: 10.1371/journal.pone.0115922. eCollection 2014.

4.

Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R.

J Hepatol. 2015 May;62(5):1180-6. doi: 10.1016/j.jhep.2014.12.011. Epub 2014 Dec 13.

5.

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.

Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T.

BMC Med Genomics. 2014 Jun 17;7:35. doi: 10.1186/1755-8794-7-35.

6.

Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation.

Liang W, Lindeman JH, Menke AL, Koonen DP, Morrison M, Havekes LM, van den Hoek AM, Kleemann R.

Lab Invest. 2014 May;94(5):491-502. doi: 10.1038/labinvest.2014.11. Epub 2014 Feb 24.

7.

Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo.

Morrison M, van der Heijden R, Heeringa P, Kaijzel E, Verschuren L, Blomhoff R, Kooistra T, Kleemann R.

Atherosclerosis. 2014 Mar;233(1):149-56. doi: 10.1016/j.atherosclerosis.2013.12.027. Epub 2014 Jan 8.

PMID:
24529136
8.

Coordinated and interactive expression of genes of lipid metabolism and inflammation in adipose tissue and liver during metabolic overload.

Liang W, Tonini G, Mulder P, Kelder T, van Erk M, van den Hoek AM, Mariman R, Wielinga PY, Baccini M, Kooistra T, Biggeri A, Kleemann R.

PLoS One. 2013 Sep 25;8(9):e75290. doi: 10.1371/journal.pone.0075290. eCollection 2013.

9.

Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trials.

van de Steeg E, Kleemann R, Jansen HT, van Duyvenvoorde W, Offerman EH, Wortelboer HM, Degroot J.

J Pharmacol Exp Ther. 2013 Dec;347(3):635-44. doi: 10.1124/jpet.113.208595. Epub 2013 Sep 18.

10.

Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression.

Kim ES, Cha Y, Ham M, Jung J, Kim SG, Hwang S, Kleemann R, Moon A.

Oncogene. 2014 Jul 3;33(27):3583-93. doi: 10.1038/onc.2013.319. Epub 2013 Aug 19.

PMID:
23955082
11.

Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet.

Yakala GK, Wielinga PY, Suarez M, Bunschoten A, van Golde JM, Arola L, Keijer J, Kleemann R, Kooistra T, Heeringa P.

Mol Nutr Food Res. 2013 Nov;57(11):2039-48. doi: 10.1002/mnfr.201200858. Epub 2013 Aug 15.

PMID:
23946229
12.

Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Radonjic M, Wielinga PY, Wopereis S, Kelder T, Goelela VS, Verschuren L, Toet K, van Duyvenvoorde W, van der Werff van der Vat B, Stroeve JH, Cnubben N, Kooistra T, van Ommen B, Kleemann R.

PLoS One. 2013;8(2):e56122. doi: 10.1371/journal.pone.0056122. Epub 2013 Feb 15.

13.

A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation.

van der Meij E, Koning GG, Vriens PW, Peeters MF, Meijer CA, Kortekaas KE, Dalman RL, van Bockel JH, Hanemaaijer R, Kooistra T, Kleemann R, Lindeman JH.

PLoS One. 2013;8(1):e53882. doi: 10.1371/journal.pone.0053882. Epub 2013 Jan 22.

14.

Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

Oksaharju A, Kooistra T, Kleemann R, van Duyvenvoorde W, Miettinen M, Lappalainen J, Lindstedt KA, Kovanen PT, Korpela R, Kekkonen RA.

Br J Nutr. 2013 Jul 14;110(1):77-85. doi: 10.1017/S0007114512004801. Epub 2012 Dec 5.

PMID:
23211714
15.

Heart failure determines the myocardial inflammatory response to injury.

Kortekaas KA, Lindeman JH, Versteegh MI, van Beelen E, Kleemann R, Klautz RJ.

Eur J Heart Fail. 2013 Apr;15(4):400-7. doi: 10.1093/eurjhf/hfs183. Epub 2012 Nov 9.

PMID:
23143795
16.

Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy.

Verschuren L, Radonjic M, Wielinga PY, Kelder T, Kooistra T, van Ommen B, Kleemann R.

Pharmacogenet Genomics. 2012 Dec;22(12):837-45. doi: 10.1097/FPC.0b013e328359d274.

PMID:
23086299
17.

Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function.

Yakala GK, van der Heijden R, Molema G, Schipper M, Wielinga PY, Kleemann R, Kooistra T, Heeringa P.

PLoS One. 2012;7(9):e45866. doi: 10.1371/journal.pone.0045866. Epub 2012 Sep 25.

18.

Building multivariate systems biology models.

Kirwan GM, Johansson E, Kleemann R, Verheij ER, Wheelock ÅM, Goto S, Trygg J, Wheelock CE.

Anal Chem. 2012 Aug 21;84(16):7064-71. doi: 10.1021/ac301269r. Epub 2012 Aug 2.

PMID:
22856472
19.

Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice.

Wielinga PY, Harthoorn LF, Verschuren L, Schoemaker MH, Jouni ZE, van Tol EA, Kleemann R, Kooistra T.

Mol Nutr Food Res. 2012 Jul;56(7):1081-9. doi: 10.1002/mnfr.201100762. Epub 2012 May 18.

PMID:
22611002
20.

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status.

Pellis L, van Erk MJ, van Ommen B, Bakker GC, Hendriks HF, Cnubben NH, Kleemann R, van Someren EP, Bobeldijk I, Rubingh CM, Wopereis S.

Metabolomics. 2012 Apr;8(2):347-359. Epub 2011 May 28.

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