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Items: 1 to 20 of 114

1.

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis (NASH) and hepatic fibrosis in LDLR-/-.Leiden mice.

Morrison MC, Mulder P, Salic K, Verheij J, Liang W, van Duyvenvoorde W, Menke A, Kooistra T, Kleemann R, Wielinga PY.

Int J Obes (Lond). 2016 Apr 28. doi: 10.1038/ijo.2016.74. [Epub ahead of print]

PMID:
27121255
2.

Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity.

Arnoldussen IA, Zerbi V, Wiesmann M, Noordman RH, Bolijn S, Mutsaers MP, Dederen PJ, Kleemann R, Kooistra T, van Tol EA, Gross G, Schoemaker MH, Heerschap A, Wielinga PY, Kiliaan AJ.

J Nutr Biochem. 2016 Apr;30:177-88. doi: 10.1016/j.jnutbio.2015.12.011. Epub 2016 Jan 21.

PMID:
27012634
3.

Obesity-induced chronic inflammation in high fat diet challenged C57BL/6J mice is associated with acceleration of age-dependent renal amyloidosis.

van der Heijden RA, Bijzet J, Meijers WC, Yakala GK, Kleemann R, Nguyen TQ, de Boer RA, Schalkwijk CG, Hazenberg BP, Tietge UJ, Heeringa P.

Sci Rep. 2015 Nov 13;5:16474. doi: 10.1038/srep16474.

4.

Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity.

Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R.

Int J Obes (Lond). 2016 Apr;40(4):675-84. doi: 10.1038/ijo.2015.226. Epub 2015 Oct 26.

5.

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil.

Morrison MC, Mulder P, Stavro PM, Suárez M, Arola-Arnal A, van Duyvenvoorde W, Kooistra T, Wielinga PY, Kleemann R.

PLoS One. 2015 Sep 25;10(9):e0139196. doi: 10.1371/journal.pone.0139196. eCollection 2015.

6.

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.

Liang W, Verschuren L, Mulder P, van der Hoorn JW, Verheij J, van Dam AD, Boon MR, Princen HM, Havekes LM, Kleemann R, van den Hoek AM.

Br J Pharmacol. 2015 Nov;172(22):5293-305. doi: 10.1111/bph.13315. Epub 2015 Oct 22.

PMID:
26292849
7.
8.

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice.

van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PP, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DP, Heeringa P.

Aging (Albany NY). 2015 Apr;7(4):256-68.

9.

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology.

Liang W, Menke AL, Driessen A, Koek GH, Lindeman JH, Stoop R, Havekes LM, Kleemann R, van den Hoek AM.

PLoS One. 2014 Dec 23;9(12):e115922. doi: 10.1371/journal.pone.0115922. eCollection 2014.

10.

Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R.

J Hepatol. 2015 May;62(5):1180-6. doi: 10.1016/j.jhep.2014.12.011. Epub 2014 Dec 13.

11.

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.

Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T.

BMC Med Genomics. 2014 Jun 17;7:35. doi: 10.1186/1755-8794-7-35.

12.

Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation.

Liang W, Lindeman JH, Menke AL, Koonen DP, Morrison M, Havekes LM, van den Hoek AM, Kleemann R.

Lab Invest. 2014 May;94(5):491-502. doi: 10.1038/labinvest.2014.11. Epub 2014 Feb 24.

13.

Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo.

Morrison M, van der Heijden R, Heeringa P, Kaijzel E, Verschuren L, Blomhoff R, Kooistra T, Kleemann R.

Atherosclerosis. 2014 Mar;233(1):149-56. doi: 10.1016/j.atherosclerosis.2013.12.027. Epub 2014 Jan 8.

PMID:
24529136
14.

Coordinated and interactive expression of genes of lipid metabolism and inflammation in adipose tissue and liver during metabolic overload.

Liang W, Tonini G, Mulder P, Kelder T, van Erk M, van den Hoek AM, Mariman R, Wielinga PY, Baccini M, Kooistra T, Biggeri A, Kleemann R.

PLoS One. 2013 Sep 25;8(9):e75290. doi: 10.1371/journal.pone.0075290. eCollection 2013.

15.

Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trials.

van de Steeg E, Kleemann R, Jansen HT, van Duyvenvoorde W, Offerman EH, Wortelboer HM, Degroot J.

J Pharmacol Exp Ther. 2013 Dec;347(3):635-44. doi: 10.1124/jpet.113.208595. Epub 2013 Sep 18.

16.

Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression.

Kim ES, Cha Y, Ham M, Jung J, Kim SG, Hwang S, Kleemann R, Moon A.

Oncogene. 2014 Jul 3;33(27):3583-93. doi: 10.1038/onc.2013.319. Epub 2013 Aug 19.

PMID:
23955082
17.

Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet.

Yakala GK, Wielinga PY, Suarez M, Bunschoten A, van Golde JM, Arola L, Keijer J, Kleemann R, Kooistra T, Heeringa P.

Mol Nutr Food Res. 2013 Nov;57(11):2039-48. doi: 10.1002/mnfr.201200858. Epub 2013 Aug 15.

PMID:
23946229
18.

Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Radonjic M, Wielinga PY, Wopereis S, Kelder T, Goelela VS, Verschuren L, Toet K, van Duyvenvoorde W, van der Werff van der Vat B, Stroeve JH, Cnubben N, Kooistra T, van Ommen B, Kleemann R.

PLoS One. 2013;8(2):e56122. doi: 10.1371/journal.pone.0056122. Epub 2013 Feb 15.

19.

A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation.

van der Meij E, Koning GG, Vriens PW, Peeters MF, Meijer CA, Kortekaas KE, Dalman RL, van Bockel JH, Hanemaaijer R, Kooistra T, Kleemann R, Lindeman JH.

PLoS One. 2013;8(1):e53882. doi: 10.1371/journal.pone.0053882. Epub 2013 Jan 22.

20.

Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

Oksaharju A, Kooistra T, Kleemann R, van Duyvenvoorde W, Miettinen M, Lappalainen J, Lindstedt KA, Kovanen PT, Korpela R, Kekkonen RA.

Br J Nutr. 2013 Jul 14;110(1):77-85. doi: 10.1017/S0007114512004801. Epub 2012 Dec 5.

PMID:
23211714
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