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Antihypertensive Medications and the Prevalence of Hyperkalemia in a Large Health System.

Chang AR, Sang Y, Leddy J, Yahya T, Kirchner HL, Inker LA, Matsushita K, Ballew SH, Coresh J, Grams ME.

Hypertension. 2016 Apr 11. pii: HYPERTENSIONAHA.116.07363. [Epub ahead of print]


Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.

Kirchner H, Sinha I, Gao H, Ruby MA, Schönke M, Lindvall JM, Barrès R, Krook A, Näslund E, Dahlman-Wright K, Zierath JR.

Mol Metab. 2016 Jan 2;5(3):171-83. doi: 10.1016/j.molmet.2015.12.004. eCollection 2016 Mar.


Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

Dewey FE, Gusarova V, O'Dushlaine C, Gottesman O, Trejos J, Hunt C, Van Hout CV, Habegger L, Buckler D, Lai KM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Ledbetter DH, Penn J, Lopez A, Borecki IB, Overton JD, Reid JG, Carey DJ, Murphy AJ, Yancopoulos GD, Baras A, Gromada J, Shuldiner AR.

N Engl J Med. 2016 Mar 24;374(12):1123-33. doi: 10.1056/NEJMoa1510926. Epub 2016 Mar 2.


The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research.

Carey DJ, Fetterolf SN, Davis FD, Faucett WA, Kirchner HL, Mirshahi U, Murray MF, Smelser DT, Gerhard GS, Ledbetter DH.

Genet Med. 2016 Feb 11. doi: 10.1038/gim.2015.187. [Epub ahead of print]



Verma A, Leader JB, Verma SS, Frase A, Wallace J, Dudek S, Lavage DR, VAN Hout CV, Dewey FE, Penn J, Lopez A, Overton JD, Carey DJ, Ledbetter DH, Kirchner HL, Ritchie MD, Pendergrass SA.

Pac Symp Biocomput. 2016;21:168-79.


Who Must We Target Now to Minimize Future Cardiovascular Events and Total Mortality?: Lessons From the Surveillance, Prevention and Management of Diabetes Mellitus (SUPREME-DM) Cohort Study.

Desai JR, Vazquez-Benitez G, Xu Z, Schroeder EB, Karter AJ, Steiner JF, Nichols GA, Reynolds K, Xu S, Newton K, Pathak RD, Waitzfelder B, Lafata JE, Butler MG, Kirchner HL, Thomas A, O'Connor PJ; SUPREME-DM Study Group.

Circ Cardiovasc Qual Outcomes. 2015 Sep;8(5):508-16.



Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.


Does Preoperative Platelet Function Predict Bleeding in Patients Undergoing Off Pump Coronary Artery Bypass Surgery?

Berger PB, Kirchner HL, Wagner ES, Ismail-Sayed I, Yahya S, Benoit C, Blankenship JC, Carter R, Casale AS, Green SM, Scott TD, Skelding KA, Woods E, Henry YM.

J Interv Cardiol. 2015 Jun;28(3):223-32. doi: 10.1111/joic.12200. Epub 2015 May 20.


Assessing the Quality of Death and Dying in an Integrated Health Care System in Rural Pennsylvania.

Darer JD, Clarke DN, Sees AC, Berger AL, Kirchner HL, Stametz RA, Davis D.

J Pain Symptom Manage. 2015 Sep;50(3):343-349.e6. doi: 10.1016/j.jpainsymman.2015.03.011. Epub 2015 May 15.


Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study.

Wiseman CA, Mandalakas AM, Kirchner HL, Gie RP, Schaaf HS, Walters E, Hesseling AC.

Int J Tuberc Lung Dis. 2015 Apr;19(4):446-53. doi: 10.5588/ijtld.14.0585.


mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.

Mannerås-Holm L, Kirchner H, Björnholm M, Chibalin AV, Zierath JR.

Physiol Rep. 2015 Apr;3(4). pii: e12372. doi: 10.14814/phy2.12372.


Tachykinin-1 in the central nervous system regulates adiposity in rodents.

Trivedi C, Shan X, Tung YC, Kabra D, Holland J, Amburgy S, Heppner K, Kirchner H, Yeo GS, Perez-Tilve D.

Endocrinology. 2015 May;156(5):1714-23. doi: 10.1210/en.2014-1781. Epub 2015 Mar 9.


Preventable major cardiovascular events associated with uncontrolled glucose, blood pressure, and lipids and active smoking in adults with diabetes with and without cardiovascular disease: a contemporary analysis.

Vazquez-Benitez G, Desai JR, Xu S, Goodrich GK, Schroeder EB, Nichols GA, Segal J, Butler MG, Karter AJ, Steiner JF, Newton KM, Morales LS, Pathak RD, Thomas A, Reynolds K, Kirchner HL, Waitzfelder B, Elston Lafata J, Adibhatla R, Xu Z, O'Connor PJ.

Diabetes Care. 2015 May;38(5):905-12. doi: 10.2337/dc14-1877. Epub 2015 Feb 20.


Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting.

Mandalakas AM, Kirchner HL, Walzl G, Gie RP, Schaaf HS, Cotton MF, Grewal HM, Hesseling AC.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):820-30. doi: 10.1164/rccm.201406-1165OC.


Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP.

Cell Metab. 2015 Jan 6;21(1):138-49. doi: 10.1016/j.cmet.2014.12.014.


Contrasting Association Results between Existing PheWAS Phenotype Definition Methods and Five Validated Electronic Phenotypes.

Leader JB, Pendergrass SA, Verma A, Carey DJ, Hartzel DN, Ritchie MD, Kirchner HL.

AMIA Annu Symp Proc. 2015 Nov 5;2015:824-32. eCollection 2015.


Trends in diabetes incidence among 7 million insured adults, 2006-2011: the SUPREME-DM project.

Nichols GA, Schroeder EB, Karter AJ, Gregg EW, Desai J, Lawrence JM, O'Connor PJ, Xu S, Newton KM, Raebel MA, Pathak RD, Waitzfelder B, Segal J, Lafata JE, Butler MG, Kirchner HL, Thomas A, Steiner JF; SUPREME-DM Study Group.

Am J Epidemiol. 2015 Jan 1;181(1):32-9. doi: 10.1093/aje/kwu255. Epub 2014 Dec 16.


The Ariadne principles: how to handle multimorbidity in primary care consultations.

Muth C, van den Akker M, Blom JW, Mallen CD, Rochon J, Schellevis FG, Becker A, Beyer M, Gensichen J, Kirchner H, Perera R, Prados-Torres A, Scherer M, Thiem U, van den Bussche H, Glasziou PP.

BMC Med. 2014 Dec 8;12:223. doi: 10.1186/s12916-014-0223-1.


Population risk factor estimates for abdominal aortic aneurysm from electronic medical records: a case control study.

Smelser DT, Tromp G, Elmore JR, Kuivaniemi H, Franklin DP, Kirchner HL, Carey DJ.

BMC Cardiovasc Disord. 2014 Dec 4;14:174. doi: 10.1186/1471-2261-14-174.


Improving the quality of care of patients with rheumatic disease using patient-centric electronic redesign software.

Newman ED, Lerch V, Billet J, Berger A, Kirchner HL.

Arthritis Care Res (Hoboken). 2015 Apr;67(4):546-53. doi: 10.1002/acr.22479.

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