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Results: 1 to 20 of 65

1.

Consent for nondiagnostic research biopsies: a pilot study of participant recall and therapeutic orientation.

Abadie R, Kimmelman J, Lafleur J, Lemmens T.

IRB. 2014 May-Jun;36(3):9-15. No abstract available.

PMID:
24946507
[PubMed - indexed for MEDLINE]
2.

Distinguishing between exploratory and confirmatory preclinical research will improve translation.

Kimmelman J, Mogil JS, Dirnagl U.

PLoS Biol. 2014 May 20;12(5):e1001863. doi: 10.1371/journal.pbio.1001863. eCollection 2014 May.

PMID:
24844265
[PubMed - in process]
Free PMC Article
3.

Late, never or non-existent: the inaccessibility of preclinical evidence for new drugs.

Federico CA, Carlisle B, Kimmelman J, Fergusson DA.

Br J Pharmacol. 2014 May 13. doi: 10.1111/bph.12771. [Epub ahead of print]

PMID:
24825131
[PubMed - as supplied by publisher]
4.

The questionable use of unequal allocation in confirmatory trials.

Hey SP, Kimmelman J.

Neurology. 2014 Jan 7;82(1):77-9. doi: 10.1212/01.wnl.0000438226.10353.1c. Epub 2013 Dec 4. Review.

PMID:
24306005
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

Henderson VC, Kimmelman J, Fergusson D, Grimshaw JM, Hackam DG.

PLoS Med. 2013;10(7):e1001489. doi: 10.1371/journal.pmed.1001489. Epub 2013 Jul 23. Review.

PMID:
23935460
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Reporting practices of pharmacodynamic studies involving invasive research procedures in cancer trials.

Freeman GA, Kimmelman J, Dancey J, Monzon JG.

Br J Cancer. 2013 Aug 20;109(4):897-908. doi: 10.1038/bjc.2013.417. Epub 2013 Jul 25.

PMID:
23887602
[PubMed - indexed for MEDLINE]
7.

Ethics, error, and initial trials of efficacy.

Hey SP, Kimmelman J.

Sci Transl Med. 2013 May 8;5(184):184fs16. doi: 10.1126/scitranslmed.3005684.

PMID:
23658242
[PubMed - indexed for MEDLINE]
8.

Position statement on the provision and procurement of human eggs for stem cell research.

Haimes E, Skene L, Ballantyne AJ, Caulfield T, Goldstein LS, Hyun I, Kimmelman J, Robert JS, Roxland BE, Scott CT, Solbakk JH, Sugarman J, Taylor PL, Testa G; ISSCR.

Cell Stem Cell. 2013 Mar 7;12(3):285-91. doi: 10.1016/j.stem.2013.02.002.

PMID:
23472870
[PubMed - indexed for MEDLINE]
Free Article
9.

Beyond human subjects: risk, ethics, and clinical development of nanomedicines.

Kimmelman J.

J Law Med Ethics. 2012 Winter;40(4):841-7. doi: 10.1111/j.1748-720X.2012.00712.x.

PMID:
23289686
[PubMed - indexed for MEDLINE]
10.

Ethical and policy issues in the clinical translation of stem cells: report of a focus session at the ISSCR Tenth Annual Meeting.

Kato K, Kimmelman J, Robert J, Sipp D, Sugarman J.

Cell Stem Cell. 2012 Dec 7;11(6):765-7. doi: 10.1016/j.stem.2012.11.004.

PMID:
23217422
[PubMed - indexed for MEDLINE]
Free Article
11.

Analysis of consent validity for invasive, nondiagnostic research procedures.

Kimmelman J, Lemmens T, Kim SY.

IRB. 2012 Sep-Oct;34(5):1-7. No abstract available.

PMID:
23072039
[PubMed - indexed for MEDLINE]
12.

The social function of clinical equipoise.

Kimmelman J.

Clin Trials. 2012 Oct;9(5):630-1. doi: 10.1177/1740774512455261. No abstract available.

PMID:
23060321
[PubMed - indexed for MEDLINE]
13.

A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries.

Kimmelman J.

Trials. 2012 Sep 22;13:173. doi: 10.1186/1745-6215-13-173. Review.

PMID:
22999017
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Publication and reporting conduct for pharmacodynamic analyses of tumor tissue in early-phase oncology trials.

Freeman GA, Kimmelman J.

Clin Cancer Res. 2012 Dec 1;18(23):6478-84. doi: 10.1158/1078-0432.CCR-12-1384. Epub 2012 Aug 21.

PMID:
22912391
[PubMed - indexed for MEDLINE]
Free Article
15.

Are phase 1 trials therapeutic? Risk, ethics, and division of labor.

Anderson JA, Kimmelman J.

Bioethics. 2014 Mar;28(3):138-46. doi: 10.1111/j.1467-8519.2012.01979.x. Epub 2012 Jun 10.

PMID:
22681632
[PubMed - in process]
16.

Should preclinical studies be registered?

Kimmelman J, Anderson JA.

Nat Biotechnol. 2012 Jun 7;30(6):488-9. doi: 10.1038/nbt.2261. No abstract available.

PMID:
22678379
[PubMed - indexed for MEDLINE]
17.

Research ethics. Rethinking research ethics: the case of postmarketing trials.

London AJ, Kimmelman J, Carlisle B.

Science. 2012 May 4;336(6081):544-5. doi: 10.1126/science.1216086. No abstract available.

PMID:
22556237
[PubMed - indexed for MEDLINE]
18.

Informed consent documents do not encourage good-quality decision making.

Brehaut JC, Carroll K, Elwyn G, Saginur R, Kimmelman J, Shojania K, Syrowatka A, Nguyen T, Hoe E, Fergusson D.

J Clin Epidemiol. 2012 Jul;65(7):708-24. doi: 10.1016/j.jclinepi.2012.01.004. Epub 2012 Apr 25.

PMID:
22537428
[PubMed - indexed for MEDLINE]
19.

A canadian perspective on ethics review and neuroimaging: tensions and solutions.

Racine E, Northoff G, Menon RS, Kimmelman J, Illes J.

Can J Neurol Sci. 2011 Jul;38(4):572-9. Review.

PMID:
21672697
[PubMed - indexed for MEDLINE]
20.

Risk of surgical delivery to deep nuclei: a meta-analysis.

Kimmelman J, Duckworth K, Ramsay T, Voss T, Ravina B, Emborg ME.

Mov Disord. 2011 Jul;26(8):1415-21. doi: 10.1002/mds.23770. Epub 2011 May 14.

PMID:
21574186
[PubMed - indexed for MEDLINE]

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