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Results: 1 to 20 of 70

1.

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.

Valbuena GN, Rizzardini M, Cimini S, Siskos AP, Bendotti C, Cantoni L, Keun HC.

Mol Neurobiol. 2015 May 12. [Epub ahead of print]

PMID:
25963727
2.

diXa: a data infrastructure for chemical safety assessment.

Hendrickx DM, Aerts HJ, Caiment F, Clark D, Ebbels TM, Evelo CT, Gmuender H, Hebels DG, Herwig R, Hescheler J, Jennen DG, Jetten MJ, Kanterakis S, Keun HC, Matser V, Overington JP, Pilicheva E, Sarkans U, Segura-Lepe MP, Sotiriadou I, Wittenberger T, Wittwehr C, Zanzi A, Kleinjans JC.

Bioinformatics. 2015 May 1;31(9):1505-7. doi: 10.1093/bioinformatics/btu827. Epub 2014 Dec 12.

3.

Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH.

Cancer Prev Res (Phila). 2015 Jan;8(1):86-93. doi: 10.1158/1940-6207.CAPR-14-0100. Epub 2014 Nov 11.

PMID:
25388013
4.

Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.

Trousil S, Lee P, Pinato DJ, Ellis JK, Dina R, Aboagye EO, Keun HC, Sharma R.

Cancer Res. 2014 Dec 1;74(23):6867-77. doi: 10.1158/0008-5472.CAN-13-2409. Epub 2014 Sep 29.

PMID:
25267063
5.

Over-representation of correlation analysis (ORCA): a method for identifying associations between variable sets.

Pomyen Y, Segura M, Ebbels TM, Keun HC.

Bioinformatics. 2015 Jan 1;31(1):102-8. doi: 10.1093/bioinformatics/btu589. Epub 2014 Sep 2.

PMID:
25183485
6.

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

Maitre L, Fthenou E, Athersuch T, Coen M, Toledano MB, Holmes E, Kogevinas M, Chatzi L, Keun HC.

BMC Med. 2014 Jul 11;12:110. doi: 10.1186/1741-7015-12-110.

7.

Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy.

Chan PH, Zhang WL, Lau CH, Cheung CY, Keun HC, Tsim KW, Lam H.

Molecules. 2014 Mar 20;19(3):3460-70. doi: 10.3390/molecules19033460.

8.

The human early-life exposome (HELIX): project rationale and design.

Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražulevičienė R, Gutzkow KB, Julvez J, Keun HC, Kogevinas M, McEachan RR, Meltzer HM, Sabidó E, Schwarze PE, Siroux V, Sunyer J, Want EJ, Zeman F, Nieuwenhuijsen MJ.

Environ Health Perspect. 2014 Jun;122(6):535-44. doi: 10.1289/ehp.1307204. Epub 2014 Mar 7.

9.

Metabolomic characterization of nipple aspirate fluid by (1)H NMR spectroscopy and GC-MS.

Tredwell GD, Miller JA, Chow HH, Thompson PA, Keun HC.

J Proteome Res. 2014 Feb 7;13(2):883-9. doi: 10.1021/pr400924k. Epub 2014 Jan 7.

10.

Serum metabolomic pertubations among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Saberi Hosnijeh F, Pechlivanis A, Keun HC, Portengen L, Bueno-de-Mesquita HB, Heederik D, Vermeulen R.

Environ Mol Mutagen. 2013 Aug;54(7):558-65. doi: 10.1002/em.21802. Epub 2013 Aug 1.

PMID:
23907991
11.

Evaluation of 1H NMR metabolic profiling using biofluid mixture design.

Athersuch TJ, Malik S, Weljie A, Newton J, Keun HC.

Anal Chem. 2013 Jul 16;85(14):6674-81. doi: 10.1021/ac400449f. Epub 2013 Jun 26.

PMID:
23730812
12.

Metabolomics in toxicology and preclinical research.

Ramirez T, Daneshian M, Kamp H, Bois FY, Clench MR, Coen M, Donley B, Fischer SM, Ekman DR, Fabian E, Guillou C, Heuer J, Hogberg HT, Jungnickel H, Keun HC, Krennrich G, Krupp E, Luch A, Noor F, Peter E, Riefke B, Seymour M, Skinner N, Smirnova L, Verheij E, Wagner S, Hartung T, van Ravenzwaay B, Leist M.

ALTEX. 2013;30(2):209-25.

13.

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R.

J Proteome Res. 2013 Jun 7;12(6):2732-41. doi: 10.1021/pr400085n. Epub 2013 May 15.

PMID:
23641669
14.

Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research.

Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA; EnviroGenomarkers Project Consortium.

Environ Health Perspect. 2013 Apr;121(4):480-7. doi: 10.1289/ehp.1205657. Epub 2013 Feb 5.

15.

Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry.

Athersuch TJ, Wilson ID, Keun HC, Lindon JC.

Xenobiotica. 2013 Sep;43(9):792-802. doi: 10.3109/00498254.2013.767953. Epub 2013 Feb 6.

PMID:
23384072
16.

1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.

Jiménez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JK.

J Proteome Res. 2013 Feb 1;12(2):959-68. doi: 10.1021/pr3010106. Epub 2013 Jan 16.

PMID:
23240862
17.

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures.

Vinken M, Maes M, Cavill R, Valkenborg D, Ellis JK, Decrock E, Leybaert L, Staes A, Gevaert K, Oliveira AG, Menezes GB, Cogliati B, Dagli ML, Ebbels TM, Witters E, Keun HC, Vanhaecke T, Rogiers V.

Arch Toxicol. 2013 May;87(5):883-94. doi: 10.1007/s00204-012-0994-0. Epub 2012 Dec 7.

PMID:
23224291
18.

Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.

Lamour SD, Choi BS, Keun HC, Müller I, Saric J.

J Proteome Res. 2012 Aug 3;11(8):4211-22. doi: 10.1021/pr3003358. Epub 2012 Jul 12.

19.

Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population.

Ellis JK, Athersuch TJ, Thomas LD, Teichert F, Pérez-Trujillo M, Svendsen C, Spurgeon DJ, Singh R, Järup L, Bundy JG, Keun HC.

BMC Med. 2012 Jun 19;10:61. doi: 10.1186/1741-7015-10-61.

20.

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis.

Stewart JD, Marchan R, Lesjak MS, Lambert J, Hergenroeder R, Ellis JK, Lau CH, Keun HC, Schmitz G, Schiller J, Eibisch M, Hedberg C, Waldmann H, Lausch E, Tanner B, Sehouli J, Sagemueller J, Staude H, Steiner E, Hengstler JG.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8155-60. doi: 10.1073/pnas.1117654109. Epub 2012 May 8.

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