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Results: 9

1.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M.

EMBO J. 2015 Apr 20. pii: e201490791. [Epub ahead of print]

PMID:
25896511
2.

ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo.

Ketscher L, Knobeloch KP.

Cytokine. 2015 Mar 21. pii: S1043-4666(15)00112-X. doi: 10.1016/j.cyto.2015.03.006. [Epub ahead of print]

PMID:
25805508
3.

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.

PMID:
25605921
4.

Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.

Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A.

Circulation. 2014 Oct 28;130(18):1589-600. doi: 10.1161/CIRCULATIONAHA.114.009847. Epub 2014 Aug 27.

PMID:
25165091
5.

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.

Basters A, Geurink PP, El Oualid F, Ketscher L, Casutt MS, Krause E, Ovaa H, Knobeloch KP, Fritz G.

FEBS J. 2014 Apr;281(7):1918-28. doi: 10.1111/febs.12754. Epub 2014 Mar 3.

PMID:
24533902
6.

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.

7.

mHERC6 is the essential ISG15 E3 ligase in the murine system.

Ketscher L, Basters A, Prinz M, Knobeloch KP.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40. doi: 10.1016/j.bbrc.2011.11.071. Epub 2011 Nov 23.

PMID:
22138649
8.

A one-day, dispense-only IP-One HTRF assay for high-throughput screening of Galphaq protein-coupled receptors: towards cells as reagents.

Bergsdorf C, Kropp-Goerkis C, Kaehler I, Ketscher L, Boemer U, Parczyk K, Bader B.

Assay Drug Dev Technol. 2008 Feb;6(1):39-53. doi: 10.1089/adt.2007.108.

PMID:
18315499
9.

Phospholipase A2 inhibition at different substrate concentrations.

Böhl M, Ketscher L, Tietböhl C, Gutzeit HO.

Anal Biochem. 2006 Dec 15;359(2):280-2. Epub 2006 Sep 22. No abstract available.

PMID:
17045950
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