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The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation.
Martines AMF, van Eunen K, Reijngoud DJ, Bakker BM. Martines AMF, et al. PLoS Comput Biol. 2017 Apr 3;13(4):e1005461. doi: 10.1371/journal.pcbi.1005461. eCollection 2017 Apr. PLoS Comput Biol. 2017. PMID: 28369071 Free PMC article.
Since CoA is also a substrate for distant enzymes, it efficiently communicated the 'traffic jam' at MCKAT to the entire pathway. This novel mechanism provides a basis to explore the role of mFAO in disease and elucidate similar principles in other pathways of lipid metabol …
Since CoA is also a substrate for distant enzymes, it efficiently communicated the 'traffic jam' at MCKAT to the entire pathway. This …
Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.
Feichtinger RG, Weis S, Mayr JA, Zimmermann FA, Bogner B, Sperl W, Kofler B. Feichtinger RG, et al. Neuro Oncol. 2016 Feb;18(2):184-94. doi: 10.1093/neuonc/nov105. Epub 2015 Jun 23. Neuro Oncol. 2016. PMID: 26106125 Free PMC article.
CONCLUSIONS: The reduction of OXPHOS complexes in meningiomas and peripheral nerve sheath tumors has potential therapeutic implications, since respiratory chain-deficient tumor cells might be selectively starved by inhibitors of glycolysis or by ketogenic diet....
CONCLUSIONS: The reduction of OXPHOS complexes in meningiomas and peripheral nerve sheath tumors has potential therapeutic implications, sin …
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD. Mitchell JA, et al. Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3. Circ Res. 2018. PMID: 29298774 Free PMC article.
Prostacyclin and thromboxane A(2) are formed after the concerted actions of cPLA(2)alpha (cytosolic phospholipase A(2)) and COX (cyclooxygenase). Urinary 2,3-dinor-6-keto-PGF(1alpha) (PGI-M) and 11-dehydro-TXB(2) (TX-M) have been taken as biomarkers of prostacyclin and thr …
Prostacyclin and thromboxane A(2) are formed after the concerted actions of cPLA(2)alpha (cytosolic phospholipase A(2)) and COX (cyclooxygen …
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression.
Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS, Warner TD, Nicolaou A, Herschman HR, Mitchell JA. Kirkby NS, et al. PLoS One. 2013 Jul 9;8(7):e69524. doi: 10.1371/journal.pone.0069524. Print 2013. PLoS One. 2013. PMID: 23874970 Free PMC article.
Our experiments have relied on immunoassays to detect the prostacyclin breakdown product, 6-keto-PGF1alpha and antibodies to detect COX-2 protein. Whilst these are standard approaches, used by many laboratories, antibody-based techniques are inherently indirect and have be …
Our experiments have relied on immunoassays to detect the prostacyclin breakdown product, 6-keto-PGF1alpha and antibodies to detect C …
[Change of chart genes expression in small intestines of mouse induced by electromagnetic pulse irradiation].
Ren D, Jin J, Li X, Zeng G. Ren D, et al. Wei Sheng Yan Jiu. 2008 Jan;37(1):22-4. Wei Sheng Yan Jiu. 2008. PMID: 18421856 Chinese.
Among the 56 genes, 19 were reported with known or inferred functions, 12 up-regulated genes were catenin alpha 1 (alpha-catenin), ly-6 alloantigen(Ly-6E), fructose-6-phosphate transaminase (GF6P), ribosomal protein S17 (rpS17), small proline-rich protein 2A (Sprr2a), glandular k …
Among the 56 genes, 19 were reported with known or inferred functions, 12 up-regulated genes were catenin alpha 1 (alpha-catenin), ly-6 allo …
Characterization of three protein components required for functional reconstitution of the epoxide carboxylase multienzyme complex from Xanthobacter strain Py2.
Allen JR, Ensign SA. Allen JR, et al. J Bacteriol. 1997 May;179(10):3110-5. doi: 10.1128/jb.179.10.3110-3115.1997. J Bacteriol. 1997. PMID: 9150202 Free PMC article.
Epoxide carboxylase from Xanthobacter strain Py2 catalyzes the reductant- and NAD+-dependent carboxylation of aliphatic epoxides to beta-keto acids. Epoxide carboxylase from Xanthobacter strain Py2 has been resolved from cell extracts by anion-exchange chromatography into …
Epoxide carboxylase from Xanthobacter strain Py2 catalyzes the reductant- and NAD+-dependent carboxylation of aliphatic epoxides to beta- …