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Results: 1 to 20 of 57

1.

Entanglement model of antibody viscosity.

Schmit JD, He F, Mishra S, Ketchem RR, Woods CE, Kerwin BA.

J Phys Chem B. 2014 May 15;118(19):5044-9. doi: 10.1021/jp500434b. Epub 2014 May 2.

PMID:
24758234
[PubMed - in process]
2.

Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation.

Wang Y, Latypov RF, Lomakin A, Meyer JA, Kerwin BA, Vunnum S, Benedek GB.

Mol Pharm. 2014 May 5;11(5):1391-402. doi: 10.1021/mp400521b. Epub 2014 Apr 15.

PMID:
24679215
[PubMed - in process]
3.

Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints.

Clark NJ, Zhang H, Krueger S, Lee HJ, Ketchem RR, Kerwin B, Kanapuram SR, Treuheit MJ, McAuley A, Curtis JE.

J Phys Chem B. 2013 Nov 14;117(45):14029-38. doi: 10.1021/jp408710r. Epub 2013 Oct 31.

PMID:
24171386
[PubMed - indexed for MEDLINE]
4.

Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature.

Cheng W, Joshi SB, Jain NK, He F, Kerwin BA, Volkin DB, Middaugh CR.

J Pharm Sci. 2013 Dec;102(12):4291-304. doi: 10.1002/jps.23748. Epub 2013 Oct 18.

PMID:
24142544
[PubMed - indexed for MEDLINE]
5.

Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics.

Bi V, Jawa V, Joubert MK, Kaliyaperumal A, Eakin C, Richmond K, Pan O, Sun J, Hokom M, Goletz TJ, Wypych J, Zhou L, Kerwin BA, Narhi LO, Arora T.

J Pharm Sci. 2013 Oct;102(10):3545-55. doi: 10.1002/jps.23663. Epub 2013 Aug 7.

PMID:
23925953
[PubMed - indexed for MEDLINE]
6.

Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies.

Thakkar SV, Sahni N, Joshi SB, Kerwin BA, He F, Volkin DB, Middaugh CR.

Protein Sci. 2013 Oct;22(10):1295-305. doi: 10.1002/pro.2316. Epub 2013 Aug 19.

PMID:
23893936
[PubMed - indexed for MEDLINE]
7.

Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody.

Zhou S, Mozziconacci O, Kerwin BA, Schöneich C.

Pharm Res. 2013 May;30(5):1311-27. doi: 10.1007/s11095-012-0970-7. Epub 2013 Feb 15.

PMID:
23412915
[PubMed - indexed for MEDLINE]
8.

Light-induced conversion of Trp to Gly and Gly hydroperoxide in IgG1.

Haywood J, Mozziconacci O, Allegre KM, Kerwin BA, Schöneich C.

Mol Pharm. 2013 Mar 4;10(3):1146-50. doi: 10.1021/mp300680c. Epub 2013 Feb 6.

PMID:
23363477
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The photolysis of disulfide bonds in IgG1 and IgG2 leads to selective intramolecular hydrogen transfer reactions of cysteine Thiyl radicals, probed by covalent H/D exchange and RPLC-MS/MS analysis.

Zhou S, Mozziconacci O, Kerwin BA, Schöneich C.

Pharm Res. 2013 May;30(5):1291-9. doi: 10.1007/s11095-012-0968-1. Epub 2013 Jan 11.

PMID:
23307417
[PubMed - indexed for MEDLINE]
10.

Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses.

Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V.

J Biol Chem. 2012 Jul 20;287(30):25266-79. doi: 10.1074/jbc.M111.330902. Epub 2012 May 14.

PMID:
22584577
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements.

Cheng W, Joshi SB, He F, Brems DN, He B, Kerwin BA, Volkin DB, Middaugh CR.

J Pharm Sci. 2012 May;101(5):1701-20. doi: 10.1002/jps.23076. Epub 2012 Feb 9.

PMID:
22323186
[PubMed - indexed for MEDLINE]
12.

Effect of pH and light on aggregation and conformation of an IgG1 mAb.

Mason BD, Schöneich C, Kerwin BA.

Mol Pharm. 2012 Apr 2;9(4):774-90. doi: 10.1021/mp2004719. Epub 2012 Feb 15.

PMID:
22300012
[PubMed - indexed for MEDLINE]
13.

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA; National Heart, Lung, and Blood Institute ARDS Network.

Chest. 2012 May;141(5):1160-9. doi: 10.1378/chest.11-1766. Epub 2011 Dec 29.

PMID:
22207676
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury.

Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P; NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators.

JAMA. 2011 Oct 12;306(14):1574-81. doi: 10.1001/jama.2011.1435. Epub 2011 Oct 5. Erratum in: JAMA. 2012 Feb 8;307(6):563.

PMID:
21976613
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.

Mozziconacci O, Kerwin BA, Schöneich C.

J Phys Chem B. 2011 Oct 27;115(42):12287-305. doi: 10.1021/jp2070453. Epub 2011 Sep 30.

PMID:
21895001
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Designed experiments with binary responses.

Bower KM, Germansderfer A, Kerwin BA, Kleemann GR, Litowski JR.

J Pharm Sci. 2011 Nov;100(11):5078-9. doi: 10.1002/jps.22699. Epub 2011 Jul 5. No abstract available.

PMID:
21732372
[PubMed - indexed for MEDLINE]
17.

Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions.

He F, Woods CE, Litowski JR, Roschen LA, Gadgil HS, Razinkov VI, Kerwin BA.

Pharm Res. 2011 Jul;28(7):1552-60. doi: 10.1007/s11095-011-0388-7. Epub 2011 May 15.

PMID:
21573867
[PubMed - indexed for MEDLINE]
18.

Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):561-8. doi: 10.1164/rccm.201012-2090OC.

PMID:
21562125
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange.

Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW.

J Pharm Sci. 2011 May 5. doi: 10.1002/jps.22601. [Epub ahead of print]

PMID:
21557223
[PubMed - as supplied by publisher]
20.

Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity measurements: design of experiment and statistical analysis.

He F, Woods CE, Trilisky E, Bower KM, Litowski JR, Kerwin BA, Becker GW, Narhi LO, Razinkov VI.

J Pharm Sci. 2011 Apr;100(4):1330-40. doi: 10.1002/jps.22384. Epub 2010 Nov 2.

PMID:
24081468
[PubMed - in process]

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