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Results: 1 to 20 of 111

1.

Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved.

Wiehe K, Easterhoff D, Luo K, Nicely NI, Bradley T, Jaeger FH, Dennison SM, Zhang R, Lloyd KE, Stolarchuk C, Parks R, Sutherland LL, Scearce RM, Morris L, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Sinangil F, Phogat S, Michael NL, Kim JH, Kelsoe G, Montefiori DC, Tomaras GD, Bonsignori M, Santra S, Kepler TB, Alam SM, Moody MA, Liao HX, Haynes BF.

Immunity. 2014 Dec 18;41(6):909-18. doi: 10.1016/j.immuni.2014.11.014. Epub 2014 Nov 29.

PMID:
25526306
[PubMed - in process]
2.

Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.

Xu H, Schmidt AG, O'donnell T, Therkelsen MD, Kepler TB, Moody MA, Haynes BF, Liao H, Harrison SC, Shaw DE.

Proteins. 2014 Dec 18. doi: 10.1002/prot.24745. [Epub ahead of print]

PMID:
25524709
[PubMed - as supplied by publisher]
3.

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.

Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF.

Cell Host Microbe. 2014 Sep 10;16(3):304-13. doi: 10.1016/j.chom.2014.08.006.

PMID:
25211073
[PubMed - in process]
4.

HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

Trama AM, Moody MA, Alam SM, Jaeger FH, Lockwood B, Parks R, Lloyd KE, Stolarchuk C, Scearce R, Foulger A, Marshall DJ, Whitesides JF, Jeffries TL Jr, Wiehe K, Morris L, Lambson B, Soderberg K, Hwang KK, Tomaras GD, Vandergrift N, Jackson KJ, Roskin KM, Boyd SD, Kepler TB, Liao HX, Haynes BF.

Cell Host Microbe. 2014 Aug 13;16(2):215-26. doi: 10.1016/j.chom.2014.07.003.

PMID:
25121750
[PubMed - in process]
5.

Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.

Sacha CR, Vandergrift N, Jeffries TL Jr, McGuire E, Fouda GG, Liebl B, Marshall DJ, Gurley TC, Stiegel L, Whitesides JF, Friedman J, Badiabo A, Foulger A, Yates NL, Tomaras GD, Kepler TB, Liao HX, Haynes BF, Moody MA, Permar SR.

Mucosal Immunol. 2014 Aug 6. doi: 10.1038/mi.2014.69. [Epub ahead of print]

PMID:
25100291
[PubMed - as supplied by publisher]
6.

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF.

Cell. 2014 Jul 31;158(3):481-91. doi: 10.1016/j.cell.2014.06.022. Epub 2014 Jul 24.

PMID:
25065977
[PubMed - in process]
7.

Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.

Fera D, Schmidt AG, Haynes BF, Gao F, Liao HX, Kepler TB, Harrison SC.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10275-80. doi: 10.1073/pnas.1409954111. Epub 2014 Jun 30.

PMID:
24982157
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation.

Kepler TB, Munshaw S, Wiehe K, Zhang R, Yu JS, Woods CW, Denny TN, Tomaras GD, Alam SM, Moody MA, Kelsoe G, Liao HX, Haynes BF.

Front Immunol. 2014 Apr 22;5:170. doi: 10.3389/fimmu.2014.00170. eCollection 2014.

PMID:
24795717
[PubMed]
Free PMC Article
9.

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Nair SK, Tomaras GD, Sales AP, Boczkowski D, Chan C, Plonk K, Cai Y, Dannull J, Kepler TB, Pruitt SK, Weinhold KJ.

Sci Rep. 2014 Apr 23;4:4632. doi: 10.1038/srep04632.

PMID:
24755960
[PubMed - in process]
10.

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.

J Clin Invest. 2014 Apr 1;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10.

PMID:
24614107
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors.

Kepler TB.

F1000Res. 2013 Apr 3;2:103. doi: 10.12688/f1000research.2-103.v1. eCollection 2013.

PMID:
24555054
[PubMed]
Free PMC Article
12.

Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.

Lynch HE, Stewart SM, Kepler TB, Sempowski GD, Alam SM.

J Immunol Methods. 2014 Feb;404:1-12. doi: 10.1016/j.jim.2013.11.026. Epub 2013 Dec 4.

PMID:
24316020
[PubMed - indexed for MEDLINE]
13.

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.

Alam SM, Dennison SM, Aussedat B, Vohra Y, Park PK, Fernández-Tejada A, Stewart S, Jaeger FH, Anasti K, Blinn JH, Kepler TB, Bonsignori M, Liao HX, Sodroski JG, Danishefsky SJ, Haynes BF.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18214-9. doi: 10.1073/pnas.1317855110. Epub 2013 Oct 21.

PMID:
24145434
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Microbial colonization influences early B-lineage development in the gut lamina propria.

Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW.

Nature. 2013 Sep 5;501(7465):112-5. doi: 10.1038/nature12496. Epub 2013 Aug 21.

PMID:
23965619
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Quantification of total T-cell receptor diversity by flow cytometry and spectratyping.

Ciupe SM, Devlin BH, Markert ML, Kepler TB.

BMC Immunol. 2013 Aug 6;14:35. doi: 10.1186/1471-2172-14-35.

PMID:
23914737
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.

Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR, Haynes BF.

Nature. 2013 Apr 25;496(7446):469-76. doi: 10.1038/nature12053. Epub 2013 Apr 3.

PMID:
23552890
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.

Yang G, Holl TM, Liu Y, Li Y, Lu X, Nicely NI, Kepler TB, Alam SM, Liao HX, Cain DW, Spicer L, VandeBerg JL, Haynes BF, Kelsoe G.

J Exp Med. 2013 Feb 11;210(2):241-56. doi: 10.1084/jem.20121977. Epub 2013 Jan 28.

PMID:
23359068
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao HX, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, Pollara J, Rao M, Peachman KK, Santra S, Letvin NL, Karasavvas N, Yang ZY, Dai K, Pancera M, Gorman J, Wiehe K, Nicely NI, Rerks-Ngarm S, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Sinangil F, Kim JH, Michael NL, Kepler TB, Kwong PD, Mascola JR, Nabel GJ, Pinter A, Zolla-Pazner S, Haynes BF.

Immunity. 2013 Jan 24;38(1):176-86. doi: 10.1016/j.immuni.2012.11.011. Epub 2013 Jan 11.

PMID:
23313589
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.

Chan C, Billard M, Ramirez SA, Schmidl H, Monson E, Kepler TB.

Bull Math Biol. 2013 Jan;75(1):185-205. doi: 10.1007/s11538-012-9799-9. Epub 2013 Jan 8.

PMID:
23296998
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.

Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):264-9. doi: 10.1073/pnas.1218256109. Epub 2012 Nov 21.

PMID:
23175789
[PubMed - indexed for MEDLINE]
Free PMC Article

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