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Results: 1 to 20 of 46

1.

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW.

J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27.

PMID:
23927482
[PubMed - indexed for MEDLINE]
2.

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).

Naesens L, Guddat LW, Keough DT, van Kuilenburg AB, Meijer J, Vande Voorde J, Balzarini J.

Mol Pharmacol. 2013 Oct;84(4):615-29. doi: 10.1124/mol.113.087247. Epub 2013 Aug 1.

PMID:
23907213
[PubMed - indexed for MEDLINE]
3.

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.

Eur J Med Chem. 2013 Sep;67:81-9. doi: 10.1016/j.ejmech.2013.06.032. Epub 2013 Jun 22.

PMID:
23850568
[PubMed - indexed for MEDLINE]
4.

Auditory-motor adaptation to frequency-altered auditory feedback occurs when participants ignore feedback.

Keough D, Hawco C, Jones JA.

BMC Neurosci. 2013 Mar 9;14:25. doi: 10.1186/1471-2202-14-25.

PMID:
23497238
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19.

PMID:
23448281
[PubMed - indexed for MEDLINE]
6.

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.

Hocková D, Keough DT, Janeba Z, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2012 Jul 12;55(13):6209-23. doi: 10.1021/jm300662d. Epub 2012 Jun 22.

PMID:
22725979
[PubMed - indexed for MEDLINE]
7.

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.

Krečmerová M, Dračínský M, Hocková D, Holý A, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Feb 1;20(3):1222-30. doi: 10.1016/j.bmc.2011.12.034. Epub 2011 Dec 30.

PMID:
22249123
[PubMed - indexed for MEDLINE]
8.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Jan 15;20(2):1076-89. doi: 10.1016/j.bmc.2011.11.034. Epub 2011 Dec 1.

PMID:
22178188
[PubMed - indexed for MEDLINE]
9.

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.

de Jersey J, Holý A, Hocková D, Naesens L, Keough DT, Guddat LW.

Curr Top Med Chem. 2011;11(16):2085-102. Review.

PMID:
21619515
[PubMed - indexed for MEDLINE]
10.

Contextual cuing contributes to the independent modification of multiple internal models for vocal control.

Keough D, Jones JA.

J Neurophysiol. 2011 May;105(5):2448-56. doi: 10.1152/jn.00291.2010. Epub 2011 Feb 23.

PMID:
21346208
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.

Keough DT, Hocková D, Krecmerová M, Cesnek M, Holý A, Naesens L, Brereton IM, Winzor DJ, de Jersey J, Guddat LW.

Mol Biochem Parasitol. 2010 Oct;173(2):165-9. doi: 10.1016/j.molbiopara.2010.05.018. Epub 2010 Jun 1.

PMID:
20595032
[PubMed - indexed for MEDLINE]
12.

ERP correlates of online monitoring of auditory feedback during vocalization.

Hawco CS, Jones JA, Ferretti TR, Keough D.

Psychophysiology. 2009 Nov;46(6):1216-25. doi: 10.1111/j.1469-8986.2009.00875.x. Epub 2009 Aug 7.

PMID:
19674393
[PubMed - indexed for MEDLINE]
13.

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Hocková D, Holý A, Masojídková M, Keough DT, de Jersey J, Guddat LW.

Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. doi: 10.1016/j.bmc.2009.07.044. Epub 2009 Jul 25.

PMID:
19666228
[PubMed - indexed for MEDLINE]
14.

The sensitivity of auditory-motor representations to subtle changes in auditory feedback while singing.

Keough D, Jones JA.

J Acoust Soc Am. 2009 Aug;126(2):837-46. doi: 10.1121/1.3158600.

PMID:
19640048
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.

Keough DT, Hocková D, Holý A, Naesens LM, Skinner-Adams TS, Jersey Jd, Guddat LW.

J Med Chem. 2009 Jul 23;52(14):4391-9. doi: 10.1021/jm900267n.

PMID:
19527031
[PubMed - indexed for MEDLINE]
16.

Auditory-motor mapping for pitch control in singers and nonsingers.

Jones JA, Keough D.

Exp Brain Res. 2008 Sep;190(3):279-87. doi: 10.1007/s00221-008-1473-y. Epub 2008 Jul 1.

PMID:
18592224
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Pigeons' memory for sequences of light flashes when gap duration is an unreliable discriminative cue.

Keough D, Santi A, Van Rooyen P.

Learn Behav. 2007 May;35(2):115-22.

PMID:
17688185
[PubMed - indexed for MEDLINE]
18.

Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

Keough DT, Skinner-Adams T, Jones MK, Ng AL, Brereton IM, Guddat LW, de Jersey J.

J Med Chem. 2006 Dec 14;49(25):7479-86.

PMID:
17149876
[PubMed - indexed for MEDLINE]
19.

Differential effects of empty and filled intervals on duration estimation by pigeons: tests of an attention-sharing explanation.

Santi A, Keough D, Gagne S, Van Rooyen P.

Behav Processes. 2007 Feb 22;74(2):176-86. Epub 2006 Sep 6.

PMID:
17014969
[PubMed - indexed for MEDLINE]
20.

The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle.

Keough DT, Brereton IM, de Jersey J, Guddat LW.

J Mol Biol. 2005 Aug 5;351(1):170-81.

PMID:
15990111
[PubMed - indexed for MEDLINE]

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