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Results: 1 to 20 of 269

1.

Molecular phenotyping of a UK population: defining the human serum metabolome.

Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O'Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FC, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB.

Metabolomics. 2015;11:9-26. Epub 2014 Jul 25.

PMID:
25598764
[PubMed]
Free PMC Article
2.

The virtue of innovation: innovation through the lenses of biological evolution.

Kell DB, Lurie-Luke E.

J R Soc Interface. 2015 Feb 6;12(103). pii: 20141183. Review.

PMID:
25505138
[PubMed - as supplied by publisher]
Free Article
3.

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Currin A, Swainston N, Day PJ, Kell DB.

Chem Soc Rev. 2014 Dec 15. [Epub ahead of print]

PMID:
25503938
[PubMed - as supplied by publisher]
4.

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

Kell DB.

Trends Pharmacol Sci. 2015 Jan;36(1):15-21. doi: 10.1016/j.tips.2014.10.005. Epub 2014 Nov 10. Review.

PMID:
25458537
[PubMed - as supplied by publisher]
Free Article
5.

Eryptosis as a marker of Parkinson's disease.

Pretorius E, Swanepoel AC, Buys AV, Vermeulen N, Duim W, Kell DB.

Aging (Albany NY). 2014 Oct;6(10):788-819.

PMID:
25411230
[PubMed - in process]
Free PMC Article
6.

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.

Kell DB, Oliver SG.

Front Pharmacol. 2014 Oct 31;5:231. doi: 10.3389/fphar.2014.00231. eCollection 2014. Review.

PMID:
25400580
[PubMed]
Free PMC Article
7.

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).

Kell DB, Pretorius E.

Integr Biol (Camb). 2014 Dec 22;7(1):24-52. doi: 10.1039/c4ib00173g.

PMID:
25335120
[PubMed - in process]
8.

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

Anderson SG, Dunn WB, Banerjee M, Brown M, Broadhurst DI, Goodacre R, Cooper GJ, Kell DB, Cruickshank JK.

PLoS One. 2014 Sep 3;9(9):e103217. doi: 10.1371/journal.pone.0103217. eCollection 2014.

PMID:
25184286
[PubMed - in process]
Free PMC Article
9.

SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution.

Currin A, Swainston N, Day PJ, Kell DB.

Protein Eng Des Sel. 2014 Sep;27(9):273-80. doi: 10.1093/protein/gzu029. Epub 2014 Aug 9.

PMID:
25108914
[PubMed - in process]
Free PMC Article
10.

Event-based text mining for biology and functional genomics.

Ananiadou S, Thompson P, Nawaz R, McNaught J, Kell DB.

Brief Funct Genomics. 2014 Jun 6. pii: elu015. [Epub ahead of print]

PMID:
24907365
[PubMed - as supplied by publisher]
Free Article
11.

GeneGenie: optimized oligomer design for directed evolution.

Swainston N, Currin A, Day PJ, Kell DB.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W395-400. doi: 10.1093/nar/gku336. Epub 2014 Apr 29.

PMID:
24782527
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.

Pretorius E, Kell DB.

Integr Biol (Camb). 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k. Review.

PMID:
24714688
[PubMed - indexed for MEDLINE]
13.

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.

Kell DB, Pretorius E.

Metallomics. 2014 Apr;6(4):748-73. doi: 10.1039/c3mt00347g.

PMID:
24549403
[PubMed - indexed for MEDLINE]
14.

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.

Pretorius E, Bester J, Vermeulen N, Lipinski B, Gericke GS, Kell DB.

PLoS One. 2014 Jan 9;9(1):e85271. doi: 10.1371/journal.pone.0085271. eCollection 2014.

PMID:
24416376
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.

Bester J, Buys AV, Lipinski B, Kell DB, Pretorius E.

Front Aging Neurosci. 2013 Dec 6;5:88. doi: 10.3389/fnagi.2013.00088. eCollection 2013.

PMID:
24367334
[PubMed]
Free PMC Article
16.

Path2Models: large-scale generation of computational models from biochemical pathway maps.

Büchel F, Rodriguez N, Swainston N, Wrzodek C, Czauderna T, Keller R, Mittag F, Schubert M, Glont M, Golebiewski M, van Iersel M, Keating S, Rall M, Wybrow M, Hermjakob H, Hucka M, Kell DB, Müller W, Mendes P, Zell A, Chaouiya C, Saez-Rodriguez J, Schreiber F, Laibe C, Dräger A, Le Novère N.

BMC Syst Biol. 2013 Nov 1;7:116. doi: 10.1186/1752-0509-7-116.

PMID:
24180668
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Yeast cells with impaired drug resistance accumulate glycerol and glucose.

Dikicioglu D, Oc S, Rash BM, Dunn WB, Pir P, Kell DB, Kirdar B, Oliver SG.

Mol Biosyst. 2014 Jan;10(1):93-102. doi: 10.1039/c2mb25512j.

PMID:
24157722
[PubMed - indexed for MEDLINE]
18.

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.

Kell DB, Goodacre R.

Drug Discov Today. 2014 Feb;19(2):171-82. doi: 10.1016/j.drudis.2013.07.014. Epub 2013 Jul 26. Erratum in: Drug Discov Today. 2014 Nov;19(11):1828.

PMID:
23892182
[PubMed - in process]
Free PMC Article
19.

An analysis of a 'community-driven' reconstruction of the human metabolic network.

Swainston N, Mendes P, Kell DB.

Metabolomics. 2013 Aug;9(4):757-764. Epub 2013 Jul 12.

PMID:
23888127
[PubMed]
Free PMC Article
20.

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes.

Smallbone K, Messiha HL, Carroll KM, Winder CL, Malys N, Dunn WB, Murabito E, Swainston N, Dada JO, Khan F, Pir P, Simeonidis E, Spasić I, Wishart J, Weichart D, Hayes NW, Jameson D, Broomhead DS, Oliver SG, Gaskell SJ, McCarthy JE, Paton NW, Westerhoff HV, Kell DB, Mendes P.

FEBS Lett. 2013 Sep 2;587(17):2832-41. doi: 10.1016/j.febslet.2013.06.043. Epub 2013 Jul 4.

PMID:
23831062
[PubMed - indexed for MEDLINE]
Free PMC Article

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