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Results: 1 to 20 of 260

1.

Event-based text mining for biology and functional genomics.

Ananiadou S, Thompson P, Nawaz R, McNaught J, Kell DB.

Brief Funct Genomics. 2014 Jun 6. pii: elu015. [Epub ahead of print]

PMID:
24907365
[PubMed - as supplied by publisher]
Free Article
2.

GeneGenie: optimized oligomer design for directed evolution.

Swainston N, Currin A, Day PJ, Kell DB.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W395-400. doi: 10.1093/nar/gku336. Epub 2014 Apr 29.

PMID:
24782527
[PubMed - in process]
Free Article
3.

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.

Pretorius E, Kell DB.

Integr Biol (Camb). 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k.

PMID:
24714688
[PubMed - in process]
4.

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.

Kell DB, Pretorius E.

Metallomics. 2014 Apr;6(4):748-73. doi: 10.1039/c3mt00347g.

PMID:
24549403
[PubMed - in process]
5.

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.

Pretorius E, Bester J, Vermeulen N, Lipinski B, Gericke GS, Kell DB.

PLoS One. 2014 Jan 9;9(1):e85271. doi: 10.1371/journal.pone.0085271. eCollection 2014.

PMID:
24416376
[PubMed - in process]
Free PMC Article
6.

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.

Bester J, Buys AV, Lipinski B, Kell DB, Pretorius E.

Front Aging Neurosci. 2013 Dec 6;5:88. doi: 10.3389/fnagi.2013.00088. eCollection 2013.

PMID:
24367334
[PubMed]
Free PMC Article
7.

Path2Models: large-scale generation of computational models from biochemical pathway maps.

Büchel F, Rodriguez N, Swainston N, Wrzodek C, Czauderna T, Keller R, Mittag F, Schubert M, Glont M, Golebiewski M, van Iersel M, Keating S, Rall M, Wybrow M, Hermjakob H, Hucka M, Kell DB, Müller W, Mendes P, Zell A, Chaouiya C, Saez-Rodriguez J, Schreiber F, Laibe C, Dräger A, Le Novère N.

BMC Syst Biol. 2013 Nov 1;7:116. doi: 10.1186/1752-0509-7-116.

PMID:
24180668
[PubMed - in process]
Free Article
8.

Yeast cells with impaired drug resistance accumulate glycerol and glucose.

Dikicioglu D, Oc S, Rash BM, Dunn WB, Pir P, Kell DB, Kirdar B, Oliver SG.

Mol Biosyst. 2014 Jan;10(1):93-102. doi: 10.1039/c2mb25512j.

PMID:
24157722
[PubMed - indexed for MEDLINE]
9.

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.

Kell DB, Goodacre R.

Drug Discov Today. 2014 Feb;19(2):171-82. doi: 10.1016/j.drudis.2013.07.014. Epub 2013 Jul 26.

PMID:
23892182
[PubMed - in process]
Free PMC Article
10.

An analysis of a 'community-driven' reconstruction of the human metabolic network.

Swainston N, Mendes P, Kell DB.

Metabolomics. 2013 Aug;9(4):757-764. Epub 2013 Jul 12.

PMID:
23888127
[PubMed]
Free PMC Article
11.

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes.

Smallbone K, Messiha HL, Carroll KM, Winder CL, Malys N, Dunn WB, Murabito E, Swainston N, Dada JO, Khan F, Pir P, Simeonidis E, Spasić I, Wishart J, Weichart D, Hayes NW, Jameson D, Broomhead DS, Oliver SG, Gaskell SJ, McCarthy JE, Paton NW, Westerhoff HV, Kell DB, Mendes P.

FEBS Lett. 2013 Sep 2;587(17):2832-41. doi: 10.1016/j.febslet.2013.06.043. Epub 2013 Jul 4.

PMID:
23831062
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text.

Miwa M, Ohta T, Rak R, Rowley A, Kell DB, Pyysalo S, Ananiadou S.

Bioinformatics. 2013 Jul 1;29(13):i44-52. doi: 10.1093/bioinformatics/btt227.

PMID:
23813008
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

A community-driven global reconstruction of human metabolism.

Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novère N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BØ.

Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3.

PMID:
23455439
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy.

Pretorius E, Vermeulen N, Bester J, Lipinski B, Kell DB.

Toxicol Mech Methods. 2013 Jun;23(5):352-9. doi: 10.3109/15376516.2012.762082. Epub 2013 Apr 19.

PMID:
23278212
[PubMed - indexed for MEDLINE]
16.

Genetics and iron in the systems biology of Parkinson's disease and some related disorders.

Funke C, Schneider SA, Berg D, Kell DB.

Neurochem Int. 2013 Apr;62(5):637-52. doi: 10.1016/j.neuint.2012.11.015. Epub 2012 Dec 7. Review.

PMID:
23220386
[PubMed - indexed for MEDLINE]
Free Article
17.

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so.

Kell DB, Dobson PD, Bilsland E, Oliver SG.

Drug Discov Today. 2013 Mar;18(5-6):218-39. doi: 10.1016/j.drudis.2012.11.008. Epub 2012 Nov 30.

PMID:
23207804
[PubMed - indexed for MEDLINE]
18.

Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing.

O'Hagan S, Knowles J, Kell DB.

PLoS One. 2012;7(11):e48862. doi: 10.1371/journal.pone.0048862. Epub 2012 Nov 21.

PMID:
23185279
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Publishing: Reviews turn facts into understanding.

Kell DB.

Nature. 2012 Oct 4;490(7418):37. doi: 10.1038/490037e. No abstract available.

PMID:
23038456
[PubMed - indexed for MEDLINE]
20.

Improving metabolic flux predictions using absolute gene expression data.

Lee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P, Swainston N.

BMC Syst Biol. 2012 Jun 19;6:73. doi: 10.1186/1752-0509-6-73.

PMID:
22713172
[PubMed - indexed for MEDLINE]
Free PMC Article

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