Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 227

1.

Aminolysis of an N-diazeniumdiolated amidine as an approach to diazeniumdiolated ammonia.

Biswas D, Hrabie JA, Saavedra JE, Cao Z, Keefer LK, Ivanic J, Holland RJ.

J Org Chem. 2014 May 16;79(10):4512-6. doi: 10.1021/jo500551n. Epub 2014 May 5.

PMID:
24766285
[PubMed - in process]
2.

Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.

Maciag AE, Holland RJ, Kim Y, Kumari V, Luthers CE, Sehareen WS, Biswas D, Morris NL, Ji X, Anderson LM, Saavedra JE, Keefer LK.

J Med Chem. 2014 Mar 27;57(6):2292-302. doi: 10.1021/jm401550d. Epub 2014 Feb 25.

PMID:
24521039
[PubMed - indexed for MEDLINE]
3.

Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells.

Kaczmarek MZ, Holland RJ, Lavanier SA, Troxler JA, Fesenkova VI, Hanson CA, Cmarik JL, Saavedra JE, Keefer LK, Ruscetti SK.

Leuk Res. 2014 Mar;38(3):377-82. doi: 10.1016/j.leukres.2013.12.002. Epub 2013 Dec 12.

PMID:
24461365
[PubMed - indexed for MEDLINE]
4.

Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase.

Holland RJ, Paulisch R, Cao Z, Keefer LK, Saavedra JE, Donzelli S.

Nitric Oxide. 2013 Nov 30;35:131-6. doi: 10.1016/j.niox.2013.10.003. Epub 2013 Oct 11.

PMID:
24126017
[PubMed - indexed for MEDLINE]
5.

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.

Maciag AE, Holland RJ, Robert Cheng YS, Rodriguez LG, Saavedra JE, Anderson LM, Keefer LK.

Redox Biol. 2013 Feb 1;1(1):115-24. doi: 10.1016/j.redox.2012.12.002. eCollection 2013.

PMID:
24024144
[PubMed]
Free PMC Article
6.

Decoding nitric oxide release rates of amine-based diazeniumdiolates.

Wang YN, Collins J, Holland RJ, Keefer LK, Ivanic J.

J Phys Chem A. 2013 Aug 1;117(30):6671-7. doi: 10.1021/jp404589p. Epub 2013 Jul 23.

PMID:
23834533
[PubMed - indexed for MEDLINE]
7.

Green tea intake is associated with urinary estrogen profiles in Japanese-American women.

Fuhrman BJ, Pfeiffer RM, Wu AH, Xu X, Keefer LK, Veenstra TD, Ziegler RG.

Nutr J. 2013 Feb 15;12:25. doi: 10.1186/1475-2891-12-25.

PMID:
23413779
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.

Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A.

Nitric Oxide. 2013 Apr 1;30:17-25. doi: 10.1016/j.niox.2013.01.003. Epub 2013 Jan 28.

PMID:
23370169
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

O2-functionalized methylamine diazeniumdiolates: evidence for E ⇄ Z equilibration in an acyclic system.

Biswas D, Holland RJ, Deschamps JR, Cao Z, Keefer LK, Saavedra JE.

J Org Chem. 2012 Dec 7;77(23):10804-10. doi: 10.1021/jo3020837. Epub 2012 Nov 20.

PMID:
23137026
[PubMed - indexed for MEDLINE]
10.

Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".

Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK.

Chem Res Toxicol. 2012 Dec 17;25(12):2670-7. doi: 10.1021/tx3003142. Epub 2012 Nov 9.

PMID:
23106594
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Richard Loeppky (1937-2012).

Eisenbrand G, Gates KS, Hecht SS, Janzowski C, Keefer LK, Marnett LJ, Tannenbaum SR.

Chem Res Toxicol. 2012 Jun 18;25(6):1155-6. doi: 10.1021/tx300219b. Epub 2012 May 25. No abstract available.

PMID:
22632260
[PubMed - indexed for MEDLINE]
12.

Nitrous oxide as a primary product in base-mediated β-elimination reactions of diazeniumdiolated benzylamine derivatives.

Biswas D, Cao Z, Keefer LK, Saavedra JE.

Chem Commun (Camb). 2012 Jun 14;48(47):5931-3. doi: 10.1039/c2cc32284f. Epub 2012 May 9.

PMID:
22572739
[PubMed - indexed for MEDLINE]
13.

Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs.

Nandurdikar RS, Maciag AE, Holland RJ, Cao Z, Shami PJ, Anderson LM, Keefer LK, Saavedra JE.

Bioorg Med Chem. 2012 May 1;20(9):3094-9. doi: 10.1016/j.bmc.2012.02.045. Epub 2012 Mar 9.

PMID:
22480849
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Diazeniumdiolated carbamates: a novel class of nitric oxide donors.

Nandurdikar RS, Maciag AE, Cao Z, Keefer LK, Saavedra JE.

Bioorg Med Chem. 2012 Mar 15;20(6):2025-9. doi: 10.1016/j.bmc.2012.01.046. Epub 2012 Feb 4.

PMID:
22356735
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Estrogen metabolism and risk of breast cancer in postmenopausal women.

Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG.

J Natl Cancer Inst. 2012 Feb 22;104(4):326-39. doi: 10.1093/jnci/djr531. Epub 2012 Jan 9.

PMID:
22232133
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class.

Maciag AE, Holland RJ, Saavedra JE, Chakrapani H, Shami PJ, Keefer LK.

For Immunopathol Dis Therap. 2012;3(2):91-95.

PMID:
23585982
[PubMed]
Free PMC Article
17.

Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among premenopausal women.

Eliassen AH, Spiegelman D, Xu X, Keefer LK, Veenstra TD, Barbieri RL, Willett WC, Hankinson SE, Ziegler RG.

Cancer Res. 2012 Feb 1;72(3):696-706. doi: 10.1158/0008-5472.CAN-11-2507. Epub 2011 Dec 5.

PMID:
22144471
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The role of estrogen receptor α and β in regulating vascular smooth muscle cell proliferation is based on sex.

Hogg ME, Vavra AK, Banerjee MN, Martinez J, Jiang Q, Keefer LK, Chambon P, Kibbe MR.

J Surg Res. 2012 Mar;173(1):e1-10. doi: 10.1016/j.jss.2011.09.021. Epub 2011 Oct 8.

PMID:
22099601
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.

Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE.

J Med Chem. 2011 Nov 24;54(22):7751-8. doi: 10.1021/jm2004128. Epub 2011 Oct 28.

PMID:
22003962
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances.

Keefer LK.

ACS Chem Biol. 2011 Nov 18;6(11):1147-55. doi: 10.1021/cb200274r. Epub 2011 Sep 30. Review.

PMID:
21932836
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Loading ...
Write to the Help Desk