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In Memoriam: Richard G.H. Cotton (1940-2015).

Kazazian HH Jr, Paalman MH, Cutting GR.

Hum Mutat. 2015 Aug;36(8):741-2. doi: 10.1002/humu.22826. Epub 2015 Jul 3. No abstract available.


The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.

Goodier JL, Pereira GC, Cheung LE, Rose RJ, Kazazian HH Jr.

PLoS Genet. 2015 May 22;11(5):e1005252. doi: 10.1371/journal.pgen.1005252. eCollection 2015 May.


2014 William Allan Award introduction: Stuart Orkin.

Kazazian HH Jr.

Am J Hum Genet. 2015 Mar 5;96(3):352-3. doi: 10.1016/j.ajhg.2014.11.018. No abstract available.


Processed pseudogene insertions in somatic cells.

Kazazian HH Jr.

Mob DNA. 2014 Jul 2;5:20. doi: 10.1186/1759-8753-5-20. eCollection 2014.


In vitro screening for compounds that enhance human L1 mobilization.

Terasaki N, Goodier JL, Cheung LE, Wang YJ, Kajikawa M, Kazazian HH Jr, Okada N.

PLoS One. 2013 Sep 11;8(9):e74629. doi: 10.1371/journal.pone.0074629. eCollection 2013.


Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

Zhao K, Du J, Han X, Goodier JL, Li P, Zhou X, Wei W, Evans SL, Li L, Zhang W, Cheung LE, Wang G, Kazazian HH Jr, Yu XF.

Cell Rep. 2013 Sep 26;4(6):1108-15. doi: 10.1016/j.celrep.2013.08.019. Epub 2013 Sep 12.


Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition.

Goodier JL, Cheung LE, Kazazian HH Jr.

Nucleic Acids Res. 2013 Aug;41(15):7401-19. doi: 10.1093/nar/gkt512. Epub 2013 Jun 9.


Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles.

Mandal PK, Ewing AD, Hancks DC, Kazazian HH Jr.

Hum Mol Genet. 2013 Sep 15;22(18):3730-48. doi: 10.1093/hmg/ddt225. Epub 2013 May 21.


MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

Goodier JL, Cheung LE, Kazazian HH Jr.

PLoS Genet. 2012;8(10):e1002941. doi: 10.1371/journal.pgen.1002941. Epub 2012 Oct 18.


The minimal active human SVA retrotransposon requires only the 5'-hexamer and Alu-like domains.

Hancks DC, Mandal PK, Cheung LE, Kazazian HH Jr.

Mol Cell Biol. 2012 Nov;32(22):4718-26. doi: 10.1128/MCB.00860-12. Epub 2012 Sep 24.


Extensive somatic L1 retrotransposition in colorectal tumors.

Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, Kazazian HH Jr.

Genome Res. 2012 Dec;22(12):2328-38. doi: 10.1101/gr.145235.112. Epub 2012 Sep 11.


Active human retrotransposons: variation and disease.

Hancks DC, Kazazian HH Jr.

Curr Opin Genet Dev. 2012 Jun;22(3):191-203. doi: 10.1016/j.gde.2012.02.006. Epub 2012 Mar 8. Review.


Mobile elements in the human genome: implications for disease.

Solyom S, Kazazian HH Jr.

Genome Med. 2012 Feb 24;4(2):12. doi: 10.1186/gm311.


Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon.

Solyom S, Ewing AD, Hancks DC, Takeshima Y, Awano H, Matsuo M, Kazazian HH Jr.

Hum Mutat. 2012 Feb;33(2):369-71. doi: 10.1002/humu.21663. Epub 2011 Dec 8.


Mobile DNA transposition in somatic cells.

Kazazian HH Jr.

BMC Biol. 2011 Sep 29;9:62. doi: 10.1186/1741-7007-9-62. Review.


Retrotransposition of marked SVA elements by human L1s in cultured cells.

Hancks DC, Goodier JL, Mandal PK, Cheung LE, Kazazian HH Jr.

Hum Mol Genet. 2011 Sep 1;20(17):3386-400. doi: 10.1093/hmg/ddr245. Epub 2011 Jun 2.


Efficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors.

Sabatino DE, Lange AM, Altynova ES, Sarkar R, Zhou S, Merricks EP, Franck HG, Nichols TC, Arruda VR, Kazazian HH Jr.

Mol Ther. 2011 Mar;19(3):442-9. doi: 10.1038/mt.2010.240. Epub 2010 Nov 16.


Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans.

Ewing AD, Kazazian HH Jr.

Genome Res. 2011 Jun;21(6):985-90. doi: 10.1101/gr.114777.110. Epub 2010 Oct 27.


Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy.

Finn JD, Ozelo MC, Sabatino DE, Franck HW, Merricks EP, Crudele JM, Zhou S, Kazazian HH, Lillicrap D, Nichols TC, Arruda VR.

Blood. 2010 Dec 23;116(26):5842-8. doi: 10.1182/blood-2010-06-288001. Epub 2010 Sep 28.


High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes.

Ewing AD, Kazazian HH Jr.

Genome Res. 2010 Sep;20(9):1262-70. doi: 10.1101/gr.106419.110. Epub 2010 May 20.

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