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Items: 1 to 20 of 102


MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells.

Das F, Dey N, Bera A, Kasinath BS, Ghosh-Choudhury N, Choudhury GG.

J Biol Chem. 2016 Jul 8;291(28):14662-76. doi: 10.1074/jbc.M115.694331. Epub 2016 May 13.


The podocyte and the proteoglycan.

Kasinath BS.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F310-1. doi: 10.1152/ajprenal.00295.2016. Epub 2016 May 25. No abstract available.


Hydrogen Sulfide in Renal Physiology and Disease.

Feliers D, Lee HJ, Kasinath BS.

Antioxid Redox Signal. 2016 May 31. [Epub ahead of print]


Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy.

Das F, Ghosh-Choudhury N, Mariappan MM, Kasinath BS, Choudhury GG.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C583-96. doi: 10.1152/ajpcell.00266.2015. Epub 2016 Jan 6.


Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Ghosh Choudhury G, Hubbard GB, Barnes JL, Richardson A, Kasinath BS.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):850-7. doi: 10.1093/gerona/glv170. Epub 2015 Oct 5.


High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression.

Dey N, Bera A, Das F, Ghosh-Choudhury N, Kasinath BS, Choudhury GG.

Cell Signal. 2015 Jul;27(7):1276-85. doi: 10.1016/j.cellsig.2015.03.007. Epub 2015 Mar 20.


Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes.

Lee HJ, Feliers D, Mariappan MM, Sataranatarajan K, Choudhury GG, Gorin Y, Kasinath BS.

J Biol Chem. 2015 May 8;290(19):12014-26. doi: 10.1074/jbc.M114.615377. Epub 2015 Mar 9.


Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury.

Mariappan MM, Prasad S, D'Silva K, Cedillo E, Sataranatarajan K, Barnes JL, Choudhury GG, Kasinath BS.

J Biol Chem. 2014 Dec 19;289(51):35363-75. doi: 10.1074/jbc.M114.587840. Epub 2014 Oct 22.


TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.

Das F, Bera A, Ghosh-Choudhury N, Abboud HE, Kasinath BS, Choudhury GG.

PLoS One. 2014 Oct 15;9(10):e109608. doi: 10.1371/journal.pone.0109608. eCollection 2014.


High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression.

Das F, Ghosh-Choudhury N, Dey N, Bera A, Mariappan MM, Kasinath BS, Ghosh Choudhury G.

J Biol Chem. 2014 Nov 21;289(47):32703-16. doi: 10.1074/jbc.M114.605196. Epub 2014 Oct 6.


Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells.

Feliers D, Lee DY, Gorin Y, Kasinath BS.

Cell Signal. 2015 Jan;27(1):1-5. doi: 10.1016/j.cellsig.2014.09.024. Epub 2014 Oct 8.


Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak U, Raffel LJ, Goodarzi MO, Chen YD, Taylor HA Jr, Correa A, Sims M, Couper D, Pankow JS, Boerwinkle E, Adeyemo A, Doumatey A, Chen G, Mathias RA, Vaidya D, Singleton AB, Zonderman AB, Igo RP Jr, Sedor JR; FIND Consortium, Kabagambe EK, Siscovick DS, McKnight B, Rice K, Liu Y, Hsueh WC, Zhao W, Bielak LF, Kraja A, Province MA, Bottinger EP, Gottesman O, Cai Q, Zheng W, Blot WJ, Lowe WL, Pacheco JA, Crawford DC; eMERGE Consortium; DIAGRAM Consortium, Grundberg E; MuTHER Consortium, Rich SS, Hayes MG, Shu XO, Loos RJ, Borecki IB, Peyser PA, Cummings SR, Psaty BM, Fornage M, Iyengar SK, Evans MK, Becker DM, Kao WH, Wilson JG, Rotter JI, Sale MM, Liu S, Rotimi CN, Bowden DW; MEta-analysis of type 2 DIabetes in African Americans Consortium.

PLoS Genet. 2014 Aug 7;10(8):e1004517. doi: 10.1371/journal.pgen.1004517. eCollection 2014 Aug.


microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion.

Bera A, Das F, Ghosh-Choudhury N, Kasinath BS, Abboud HE, Choudhury GG.

Exp Cell Res. 2014 Oct 15;328(1):99-117. doi: 10.1016/j.yexcr.2014.06.022. Epub 2014 Jul 9.


Hydrogen sulfide to the rescue in obstructive kidney injury.

Kasinath BS.

Kidney Int. 2014 Jun;85(6):1255-8. doi: 10.1038/ki.2013.529.


Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN.

Rai P, Lederman R, Haque S, Rehman S, Kumar V, Sataranatrajan K, Malhotra A, Kasinath BS, Singhal PC.

Exp Mol Pathol. 2014 Jun;96(3):431-7. doi: 10.1016/j.yexmp.2014.04.004. Epub 2014 Apr 21.


A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF.

Bera A, Das F, Ghosh-Choudhury N, Li X, Pal S, Gorin Y, Kasinath BS, Abboud HE, Ghosh Choudhury G.

Am J Physiol Cell Physiol. 2014 Jun 1;306(11):C1089-100. doi: 10.1152/ajpcell.00387.2013. Epub 2014 Apr 16.


Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney.

Mariappan MM, DeSilva K, Sorice GP, Muscogiuri G, Jimenez F, Ahuja S, Barnes JL, Choudhury GG, Musi N, DeFronzo R, Kasinath BS.

Am J Physiol Cell Physiol. 2014 Feb 1;306(3):C202-11. doi: 10.1152/ajpcell.00144.2013. Epub 2013 Oct 9.


NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation.

Bera A, Ghosh-Choudhury N, Dey N, Das F, Kasinath BS, Abboud HE, Choudhury GG.

Cell Signal. 2013 Dec;25(12):2575-86. doi: 10.1016/j.cellsig.2013.08.005. Epub 2013 Aug 24.


Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.

Das F, Ghosh-Choudhury N, Bera A, Dey N, Abboud HE, Kasinath BS, Choudhury GG.

J Biol Chem. 2013 Mar 15;288(11):7756-68. doi: 10.1074/jbc.M113.455782. Epub 2013 Jan 28.


TGFβ-induced PI 3 kinase-dependent Mnk-1 activation is necessary for Ser-209 phosphorylation of eIF4E and mesangial cell hypertrophy.

Das F, Ghosh-Choudhury N, Bera A, Kasinath BS, Choudhury GG.

J Cell Physiol. 2013 Jul;228(7):1617-26. doi: 10.1002/jcp.24327.

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