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Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial.

Deschamps A, Hall R, Grocott H, Mazer CD, Choi PT, Turgeon AF, de Medicis E, Bussières JS, Hudson C, Syed S, Seal D, Herd S, Lambert J, Denault A, Deschamps A, Mutch A, Turgeon A, Denault A, Todd A, Jerath A, Fayad A, Finnegan B, Kent B, Kennedy B, Cuthbertson BH, Kavanagh B, Warriner B, MacAdams C, Lehmann C, Fudorow C, Hudson C, McCartney C, McIsaac D, Dubois D, Campbell D, Mazer D, Neilpovitz D, Rosen D, Cheng D, Drapeau D, Dillane D, Tran D, Mckeen D, Wijeysundera D, Jacobsohn E, Couture E, de Medicis E, Alam F, Abdallah F, Ralley FE, Chung F, Lellouche F, Dobson G, Germain G, Djaiani G, Gilron I, Hare G, Bryson G, Clarke H, McDonald H, Roman-Smith H, Grocott H, Yang H, Douketis J, Paul J, Beaubien J, Bussières J, Pridham J, Armstrong JN, Parlow J, Murkin J, Gamble J, Duttchen K, Karkouti K, Turner K, Baghirzada L, Szabo L, Lalu M, Wasowicz M, Bautista M, Jacka M, Murphy M, Schmidt M, Verret M, Perrault MA, Beaudet N, Buckley N, Choi P, MacDougall P, Jones P, Drolet P, Beaulieu P, Taneja R, Martin R, Hall R, George R, Chun R, McMullen S, Beattie S, Sampson S, Choi S, Kowalski S, McCluskey S, Syed S, Boet S, Ramsay T, Saha T, Mutter T, Chowdhury T, Uppal V, Mckay W; Canadian Perioperative Anesthesia Clinical Trials Group.

Anesthesiology. 2016 Apr;124(4):826-36. doi: 10.1097/ALN.0000000000001029.


In Reply.

Karkouti K, Callum J, Rao V, McCluskey SA.

Anesthesiology. 2015 Oct;123(4):975-6. doi: 10.1097/ALN.0000000000000812. No abstract available.


Validity of Thromboelastometry for Rapid Assessment of Fibrinogen Levels in Heparinized Samples During Cardiac Surgery: A Retrospective, Single-center, Observational Study.

Mace H, Lightfoot N, McCluskey S, Selby R, Roy D, Timoumi T, Karkouti K.

J Cardiothorac Vasc Anesth. 2016 Jan;30(1):90-5. doi: 10.1053/j.jvca.2015.04.030. Epub 2015 May 5.


Reliability of a point-of-care device for international normalized ratio testing during the three surgical phases of orthotopic liver transplantation: a retrospective observational study.

Mace HS, Lightfoot NJ, Cordero-Rochet MJ, Srinivas C, Karkouti K, McCluskey SA.

Can J Anaesth. 2015 Mar;62(3):258-64. doi: 10.1007/s12630-014-0283-x. Epub 2015 Feb 10.


Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study.

Karkouti K, Grocott HP, Hall R, Jessen ME, Kruger C, Lerner AB, MacAdams C, Mazer CD, de Medicis É, Myles P, Ralley F, Rheault MR, Rochon A, Slaughter MS, Sternlicht A, Syed S, Waters T.

Can J Anaesth. 2015 Apr;62(4):377-84. doi: 10.1007/s12630-014-0302-y. Epub 2014 Dec 24.


Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis.

Karkouti K, McCluskey SA, Callum J, Freedman J, Selby R, Timoumi T, Roy D, Rao V.

Anesthesiology. 2015 Mar;122(3):560-70. doi: 10.1097/ALN.0000000000000556.


Off-label use of recombinant activated factor VII in surgical and non-surgical patients at 16 Canadian hospitals from 2007 to 2010 (Canadian Registry Report).

Karkouti K, Arellano R, Aye T, Dupuis JY, Kent B, Lee TW, Lin Y, Ralley F, MacAdams C, Mazer CD, Muirhead B, Rheault MR, Rochon A, Syed S, Waters T, Wong B.

Can J Anaesth. 2014 Aug;61(8):727-35. doi: 10.1007/s12630-014-0184-z. Epub 2014 Jun 3.


Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations.

Song HK, von Heymann C, Jespersen CM, Karkouti K, Korte W, Levy JH, Ranucci M, Saugstrup T, Sellke FW.

Ann Thorac Surg. 2014 May;97(5):1630-5. doi: 10.1016/j.athoracsur.2013.12.025. Epub 2014 Mar 19.


Platelet dysfunction as measured by a point-of-care monitor is an independent predictor of high blood loss in cardiac surgery.

Orlov D, McCluskey SA, Selby R, Yip P, Pendergrast J, Karkouti K.

Anesth Analg. 2014 Feb;118(2):257-63. doi: 10.1213/ANE.0000000000000054.


From the Journal archives: The red blood cell storage lesion: past, present, and future.

Karkouti K.

Can J Anaesth. 2014 Jun;61(6):583-6. doi: 10.1007/s12630-013-0106-5. Epub 2014 Jan 9.


Universal definition of perioperative bleeding in adult cardiac surgery.

Dyke C, Aronson S, Dietrich W, Hofmann A, Karkouti K, Levi M, Murphy GJ, Sellke FW, Shore-Lesserson L, von Heymann C, Ranucci M.

J Thorac Cardiovasc Surg. 2014 May;147(5):1458-1463.e1. doi: 10.1016/j.jtcvs.2013.10.070. Epub 2013 Dec 9. Review.


Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial.

Karkouti K, von Heymann C, Jespersen CM, Korte W, Levy JH, Ranucci M, Sellke FW, Song HK.

J Thorac Cardiovasc Surg. 2013 Oct;146(4):927-39. doi: 10.1016/j.jtcvs.2013.04.044. Epub 2013 Jun 29.


Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study.

McCluskey SA, Karkouti K, Wijeysundera D, Minkovich L, Tait G, Beattie WS.

Anesth Analg. 2013 Aug;117(2):412-21. doi: 10.1213/ANE.0b013e318293d81e. Epub 2013 Jun 11.


The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study.

Karkouti K, Callum J, Crowther MA, McCluskey SA, Pendergrast J, Tait G, Yau TM, Beattie WS.

Anesth Analg. 2013 Jul;117(1):14-22. doi: 10.1213/ANE.0b013e318292efa4. Epub 2013 May 17.


Starches for fluid therapy: is it time for a re-appraisal, or has the horse left the barn?

McCluskey SA, Karkouti K.

Can J Anaesth. 2013 Jul;60(7):630-3. doi: 10.1007/s12630-013-9949-z. Epub 2013 Apr 30. No abstract available.


Seek and you shall find--but then what do you do? Cold agglutinins in cardiopulmonary bypass and a single-center experience with cold agglutinin screening before cardiac surgery.

Jain MD, Cabrerizo-Sanchez R, Karkouti K, Yau T, Pendergrast JM, Cserti-Gazdewich CM.

Transfus Med Rev. 2013 Apr;27(2):65-73. doi: 10.1016/j.tmrv.2012.12.001. Epub 2013 Feb 1.


The rationale for platelet transfusion during cardiopulmonary bypass: an observational study.

Zaffar N, Joseph A, Mazer CD, Nisenbaum R, Karkouti K, Tinmouth A, Peterson MD, Pavenski K, Callum J, Cserti-Gazdewich C, Shehata N.

Can J Anaesth. 2013 Apr;60(4):345-54. doi: 10.1007/s12630-012-9878-2. Epub 2013 Jan 24.


Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort.

Karkouti K, Stukel TA, Beattie WS, Elsaadany S, Li P, Berger R, Wijeysundera DN.

Anesthesiology. 2012 Dec;117(6):1175-83. doi: 10.1097/ALN.0b013e318271604e.


Use of clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients.

Beattie WS, Karkouti K, Tait G, Steel A, Yip P, McCluskey S, Farkouh M, Wijeysundera DN.

Can J Anaesth. 2012 Nov;59(11):1013-22. doi: 10.1007/s12630-012-9782-9. Epub 2012 Sep 8.


Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial.

Karkouti K, Wijeysundera DN, Yau TM, McCluskey SA, Chan CT, Wong PY, Crowther MA, Hozhabri S, Beattie WS.

Anesthesiology. 2012 Mar;116(3):613-21. doi: 10.1097/ALN.0b013e3182475e39.

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