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Results: 1 to 20 of 115

1.

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, Kornhuber J, Peters O, Naj AC, Chouraki V, Bellenguez C, Gerrish A; International Genomics of Alzheimer's Project (IGAP); Alzheimer's Disease Neuroimaging Initiative (ADNI), Heun R, Frölich L, Hüll M, Buscemi L, Herms S, Kölsch H, Scheltens P, Breteler MM, Rüther E, Wiltfang J, Goate A, Jessen F, Maier W, Heneka MT, Becker T, Nöthen MM.

Hum Mol Genet. 2014 Jul 15. pii: ddu372. [Epub ahead of print]

PMID:
25027320
[PubMed - as supplied by publisher]
2.

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease.

Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Mann D, Snowden J, Neary D, Harris J, Bras J; ARUK Consortium, Morgan K, Powell JF, Singleton A, Hardy J.

Neurobiol Aging. 2014 Oct;35(10):2422.e13-6. doi: 10.1016/j.neurobiolaging.2014.04.026. Epub 2014 May 2.

PMID:
24880964
[PubMed - in process]
Free Article
3.

Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.

Morgen K, Ramirez A, Frölich L, Tost H, Plichta MM, Kölsch H, Rakebrandt F, Rienhoff O, Jessen F, Peters O, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Hampel H, Teipel SJ, Pantel J, Heuser I, Wiltfang J, Rüther E, Kornhuber J, Maier W, Meyer-Lindenberg A.

Alzheimers Dement. 2014 Mar 6. pii: S1552-5260(13)02912-9. doi: 10.1016/j.jalz.2013.11.001. [Epub ahead of print]

PMID:
24613704
[PubMed - as supplied by publisher]
4.

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M; UK Brain Expression Consortium, Hardy J, Ryten M, Trabzuni D, Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K; Alzheimer’s Research UK Consortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kauwe JS, Goate AM.

Nature. 2014 Jan 23;505(7484):550-4. doi: 10.1038/nature12825. Epub 2013 Dec 11.

PMID:
24336208
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies.

Liu G, Yao L, Liu J, Jiang Y, Ma G; Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium, Chen Z, Zhao B, Li K.

Neurobiol Aging. 2014 Apr;35(4):786-92. doi: 10.1016/j.neurobiolaging.2013.10.084. Epub 2013 Oct 19.

PMID:
24231519
[PubMed - in process]
6.

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P.

Nat Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. Epub 2013 Oct 27.

PMID:
24162737
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease.

Morgen K, Frölich L, Tost H, Plichta MM, Kölsch H, Rakebrandt F, Rienhoff O, Jessen F, Peters O, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Hampel H, Teipel SJ, Pantel J, Heuser I, Wiltfang J, Rüther E, Kornhuber J, Maier W, Meyer-Lindenberg A.

J Alzheimers Dis. 2013;37(2):389-401. doi: 10.3233/JAD-130326.

PMID:
23948881
[PubMed - indexed for MEDLINE]
8.

The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.

Medway C, Combarros O, Cortina-Borja M, Butler HT, Ibrahim-Verbaas CA, de Bruijn RF, Koudstaal PJ, van Duijn CM, Ikram MA, Mateo I, Sánchez-Juan P, Lehmann MG, Heun R, Kölsch H, Deloukas P, Hammond N, Coto E, Alvarez V, Kehoe PG, Barber R, Wilcock GK, Brown K, Belbin O, Warden DR, Smith AD, Morgan K, Lehmann DJ.

Eur J Hum Genet. 2014 Feb;22(2):216-20. doi: 10.1038/ejhg.2013.116. Epub 2013 Jun 5.

PMID:
23736221
[PubMed - in process]
9.

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease.

Popp J, Meichsner S, Kölsch H, Lewczuk P, Maier W, Kornhuber J, Jessen F, Lütjohann D.

Biochem Pharmacol. 2013 Jul 1;86(1):37-42. doi: 10.1016/j.bcp.2012.12.007. Epub 2013 Jan 3.

PMID:
23291240
[PubMed - indexed for MEDLINE]
10.

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

Lee SH, Harold D, Nyholt DR; ANZGene Consortium; International Endogene Consortium; Genetic and Environmental Risk for Alzheimer's disease Consortium, Goddard ME, Zondervan KT, Williams J, Montgomery GW, Wray NR, Visscher PM.

Hum Mol Genet. 2013 Feb 15;22(4):832-41. doi: 10.1093/hmg/dds491. Epub 2012 Nov 28.

PMID:
23193196
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A polymorphic microsatellite repeat within the ECE-1c promoter is involved in transcriptional start site determination, human evolution, and Alzheimer's disease.

Li Y, Seidel K, Marschall P, Klein M, Hope A, Schacherl J, Schmitz J, Menk M, Schefe JH, Reinemund J, Hugel R, Walden P, Schlosser A, Volkmer R, Schimkus J, Kölsch H, Maier W, Kornhuber J, Frölich L, Klare S, Kirsch S, Schmerbach K, Scheele S, Grittner U, Zollmann F, Goldin-Lang P, Peters O, Kintscher U, Unger T, Funke-Kaiser H.

J Neurosci. 2012 Nov 21;32(47):16807-20. doi: 10.1523/JNEUROSCI.2636-12.2012.

PMID:
23175834
[PubMed - indexed for MEDLINE]
Free Article
12.

TREM2 variants in Alzheimer's disease.

Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group.

N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14.

PMID:
23150934
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.

Chapman J, Rees E, Harold D, Ivanov D, Gerrish A, Sims R, Hollingworth P, Stretton A; GERAD1 Consortium, Holmans P, Owen MJ, O'Donovan MC, Williams J, Kirov G.

Hum Mol Genet. 2013 Feb 15;22(4):816-24. doi: 10.1093/hmg/dds476. Epub 2012 Nov 11.

PMID:
23148125
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.

Bullock JM, Medway C, Cortina-Borja M, Turton JC, Prince JA, Ibrahim-Verbaas CA, Schuur M, Breteler MM, van Duijn CM, Kehoe PG, Barber R, Coto E, Alvarez V, Deloukas P, Hammond N, Combarros O, Mateo I, Warden DR, Lehmann MG, Belbin O, Brown K, Wilcock GK, Heun R, Kölsch H, Smith AD, Lehmann DJ, Morgan K.

Neurobiol Aging. 2013 Apr;34(4):1309.e1-7. doi: 10.1016/j.neurobiolaging.2012.08.010. Epub 2012 Oct 1.

PMID:
23036584
[PubMed - indexed for MEDLINE]
15.

Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment.

Scheef L, Spottke A, Daerr M, Joe A, Striepens N, Kölsch H, Popp J, Daamen M, Gorris D, Heneka MT, Boecker H, Biersack HJ, Maier W, Schild HH, Wagner M, Jessen F.

Neurology. 2012 Sep 25;79(13):1332-9. Epub 2012 Aug 22.

PMID:
22914828
[PubMed - indexed for MEDLINE]
16.

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation.

Marinova M, Lütjohann D, Breuer O, Kölsch H, Westhofen P, Watzka M, Mengel M, Stoffel-Wagner B, Hartmann G, Coch C, Oldenburg J.

Eur J Clin Pharmacol. 2013 Mar;69(3):467-75. doi: 10.1007/s00228-012-1362-y. Epub 2012 Aug 5.

PMID:
22864379
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.

Popp J, Lewczuk P, Kölsch H, Meichsner S, Maier W, Kornhuber J, Jessen F, Lütjohann D.

J Neurochem. 2012 Oct;123(2):310-6. doi: 10.1111/j.1471-4159.2012.07893.x. Epub 2012 Aug 23.

PMID:
22845771
[PubMed - indexed for MEDLINE]
18.

Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease.

Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F, Böger RH, Popp J.

J Alzheimers Dis. 2012;31(4):751-8. doi: 10.3233/JAD-2012-112138.

PMID:
22710910
[PubMed - indexed for MEDLINE]
19.

The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk.

Hamilton G, Harris SE, Davies G, Liewald DC, Tenesa A, Payton A, Horan MA, Ollier WE, Pendleton N; Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium, Starr JM, Porteous D, Deary IJ.

Am J Med Genet B Neuropsychiatr Genet. 2012 Sep;159B(6):696-709. doi: 10.1002/ajmg.b.32073. Epub 2012 Jun 12.

PMID:
22693153
[PubMed - indexed for MEDLINE]
20.

Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis Project.

Heun R, Kölsch H, Ibrahim-Verbaas CA, Combarros O, Aulchenko YS, Breteler M, Schuur M, van Duijn CM, Hammond N, Belbin O, Cortina-Borja M, Wilcock GK, Brown K, Barber R, Kehoe PG, Coto E, Alvarez V, Lehmann MG, Deloukas P, Mateo I, Morgan K, Warden DR, Smith AD, Lehmann DJ.

Int J Mol Epidemiol Genet. 2012;3(1):39-47. Epub 2012 Feb 23.

PMID:
22493750
[PubMed]
Free PMC Article

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