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Items: 1 to 20 of 53

1.

Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.

Lutz J, Dittmann K, Bösl MR, Winkler TH, Wienands J, Engels N.

Nat Commun. 2015 Oct 13;6:8575. doi: 10.1038/ncomms9575.

2.

The Memory Function of the B Cell Antigen Receptor.

Wienands J, Engels N.

Curr Top Microbiol Immunol. 2016;393:107-21. doi: 10.1007/82_2015_480.

PMID:
26362935
3.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
4.

The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.

Engels N, König LM, Schulze W, Radtke D, Vanshylla K, Lutz J, Winkler TH, Nitschke L, Wienands J.

Nat Commun. 2014 Nov 21;5:5456. doi: 10.1038/ncomms6456.

5.

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy.

Spitzner M, Ebner R, Wolff HA, Ghadimi BM, Wienands J, Grade M.

Cancers (Basel). 2014 Sep 29;6(4):1986-2011. doi: 10.3390/cancers6041986. Review.

6.

Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells.

Engelke M, Pirkuliyeva S, Kühn J, Wong L, Boyken J, Herrmann N, Becker S, Griesinger C, Wienands J.

Sci Signal. 2014 Aug 19;7(339):ra79. doi: 10.1126/scitranslmed.2005104.

PMID:
25140054
7.

Seroprevalence of autoantibodies against brain antigens in health and disease.

Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H.

Ann Neurol. 2014 Jul;76(1):82-94. doi: 10.1002/ana.24189. Epub 2014 Jun 23.

PMID:
24853231
8.

Reprint of: Environments of B cell development.

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F.

Immunol Lett. 2014 Aug;160(2):109-12. doi: 10.1016/j.imlet.2014.05.005. Epub 2014 May 20.

PMID:
24852107
9.

Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation.

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J.

Arthritis Rheumatol. 2014 Apr;66(4):831-40. doi: 10.1002/art.38325.

10.

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.

Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B.

Mol Cell Biol. 2014 Apr;34(8):1398-411. doi: 10.1128/MCB.00038-14. Epub 2014 Feb 3.

11.

Environments of B cell development.

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F.

Immunol Lett. 2014 Jan-Feb;157(1-2):60-3. doi: 10.1016/j.imlet.2013.11.011. Epub 2013 Nov 24. Review.

PMID:
24284375
12.

Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.

Engelke M, Oellerich T, Dittmann K, Hsiao HH, Urlaub H, Serve H, Griesinger C, Wienands J.

J Immunol. 2013 Dec 1;191(11):5354-8. doi: 10.4049/jimmunol.1301326. Epub 2013 Oct 28.

13.

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M.

Int J Cancer. 2014 Feb 15;134(4):997-1007. doi: 10.1002/ijc.28429. Epub 2013 Sep 3.

14.

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

König S, Regen T, Dittmann K, Engelke M, Wienands J, Schwendener R, Hanisch UK, Pukrop T, Hahn H.

Cancer Immunol Immunother. 2013 Oct;62(10):1587-97. doi: 10.1007/s00262-013-1444-4. Epub 2013 Aug 6.

PMID:
23917775
15.

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.

Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD.

Nat Immunol. 2013 Sep;14(9):966-75. doi: 10.1038/ni.2685. Epub 2013 Aug 4.

PMID:
23913047
16.

β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Oellerich T, Oellerich MF, Engelke M, Münch S, Mohr S, Nimz M, Hsiao HH, Corso J, Zhang J, Bohnenberger H, Berg T, Rieger MA, Wienands J, Bug G, Brandts C, Urlaub H, Serve H.

Blood. 2013 May 9;121(19):3889-99, S1-66. doi: 10.1182/blood-2012-09-457887. Epub 2013 Mar 18.

17.

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.

Marklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H.

PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.

18.

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B.

J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24.

19.

The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.

Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M.

J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5.

20.

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.

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