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Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells.

Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z.

J Basic Clin Physiol Pharmacol. 2015 Nov 5. pii: /j/jbcpp.ahead-of-print/jbcpp-2015-0071/jbcpp-2015-0071.xml. doi: 10.1515/jbcpp-2015-0071. [Epub ahead of print]


HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells.

Kozela E, Haj C, Hanuš L, Chourasia M, Shurki A, Juknat A, Kaushansky N, Mechoulam R, Vogel Z.

Chem Biol Drug Des. 2015 Aug 11. doi: 10.1111/cbdd.12637. [Epub ahead of print]


Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells.

Kozela E, Juknat A, Kaushansky N, Ben-Nun A, Coppola G, Vogel Z.

J Neuroinflammation. 2015 Mar 15;12:52. doi: 10.1186/s12974-015-0273-0.


Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.

Rimmerman N, Ben-Hail D, Porat Z, Juknat A, Kozela E, Daniels MP, Connelly PS, Leishman E, Bradshaw HB, Shoshan-Barmatz V, Vogel Z.

Cell Death Dis. 2013 Dec 5;4:e949. doi: 10.1038/cddis.2013.471.


Cannabinoids decrease the th17 inflammatory autoimmune phenotype.

Kozela E, Juknat A, Kaushansky N, Rimmerman N, Ben-Nun A, Vogel Z.

J Neuroimmune Pharmacol. 2013 Dec;8(5):1265-76. doi: 10.1007/s11481-013-9493-1. Epub 2013 Jul 28.


Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells.

Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Gao F, Coppola G, Geschwind D, Vogel Z.

PLoS One. 2013 Apr 24;8(4):e61462. doi: 10.1371/journal.pone.0061462. Print 2013.


Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells.

Juknat A, Rimmerman N, Levy R, Vogel Z, Kozela E.

Neurochem Int. 2012 Nov;61(6):923-30. doi: 10.1016/j.neuint.2011.12.002. Epub 2011 Dec 9.


Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells.

Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Coppola G, Geschwind D, Vogel Z.

Br J Pharmacol. 2012 Apr;165(8):2512-28. doi: 10.1111/j.1476-5381.2011.01461.x.


The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells.

Rimmerman N, Juknat A, Kozela E, Levy R, Bradshaw HB, Vogel Z.

Cell Mol Neurobiol. 2011 Aug;31(6):921-30. doi: 10.1007/s10571-011-9692-3. Epub 2011 Apr 30.


Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line devoid of caveolin-1.

Rimmerman N, Bradshaw HB, Kozela E, Levy R, Juknat A, Vogel Z.

Br J Pharmacol. 2012 Apr;165(8):2436-49. doi: 10.1111/j.1476-5381.2011.01380.x.


Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice.

Kozela E, Lev N, Kaushansky N, Eilam R, Rimmerman N, Levy R, Ben-Nun A, Juknat A, Vogel Z.

Br J Pharmacol. 2011 Aug;163(7):1507-19. doi: 10.1111/j.1476-5381.2011.01379.x.


N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.

McHugh D, Hu SS, Rimmerman N, Juknat A, Vogel Z, Walker JM, Bradshaw HB.

BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44.


Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells.

Kozela E, Pietr M, Juknat A, Rimmerman N, Levy R, Vogel Z.

J Biol Chem. 2010 Jan 15;285(3):1616-26. doi: 10.1074/jbc.M109.069294. Epub 2009 Nov 12.


Differential changes in GPR55 during microglial cell activation.

Pietr M, Kozela E, Levy R, Rimmerman N, Lin YH, Stella N, Vogel Z, Juknat A.

FEBS Lett. 2009 Jun 18;583(12):2071-6. doi: 10.1016/j.febslet.2009.05.028. Epub 2009 May 22.


Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family.

Gonzalez LE, Juknat AA, Venosa AJ, Verrengia N, Kotler ML.

Neurochem Int. 2008 Dec;53(6-8):408-15. doi: 10.1016/j.neuint.2008.09.008. Epub 2008 Sep 21.


Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine.

Matas D, Juknat A, Pietr M, Klin Y, Vogel Z.

J Biol Chem. 2007 Mar 16;282(11):7885-92. Epub 2007 Jan 16.


Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas.

Butovsky E, Juknat A, Elbaz J, Shabat-Simon M, Eilam R, Zangen A, Altstein M, Vogel Z.

Mol Cell Neurosci. 2006 Apr;31(4):795-804. Epub 2006 Mar 2.


In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol.

Butovsky E, Juknat A, Goncharov I, Elbaz J, Eilam R, Zangen A, Vogel Z.

J Neurochem. 2005 May;93(4):802-11.


Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes.

Juknat AA, Méndez Mdel V, Quaglino A, Fameli CI, Mena M, Kotler ML.

J Pineal Res. 2005 Mar;38(2):84-92.


Necrotic cell death induced by delta-aminolevulinic acid in mouse astrocytes. Protective role of melatonin and other antioxidants.

Juknat AA, Kotler ML, Quaglino A, Carrillo NM, Hevor T.

J Pineal Res. 2003 Aug;35(1):1-11.

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