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Results: 1 to 20 of 99

1.

Preclinical target validation using patient-derived cells.

Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M, Barker P, Barsyte D, Bengtson MH, Bell C, Bowness P, Boycott KM, Buser-Doepner C, Carpenter CL, Carr AJ, Clark K, Das AM, Dhanak D, Dirks P, Ellis J, Fantin VR, Flores C, Fon EA, Frail DE, Gileadi O, O'Hagan RC, Howe T, Isaac JT, Jabado N, Jakobsson PJ, Klareskog L, Knapp S, Lee WH, Lima-Fernandes E, Lundberg IE, Marshall J, Massirer KB, MacKenzie AE, Maruyama T, Mueller-Fahrnow A, Muthuswamy S, Nanchahal J, O'Brien C, Oppermann U, Ostermann N, Petrecca K, Pollock BG, Poupon V, Prinjha RK, Rosenberg SH, Rouleau G, Skingle M, Slutsky AS, Smith GA, Verhelle D, Widmer H, Young LT.

Nat Rev Drug Discov. 2015 Mar;14(3):149-50. doi: 10.1038/nrd4565. Epub 2015 Feb 20.

PMID:
25722227
[PubMed - in process]
2.

IgG antibodies to cyclic citrullinated peptides exhibit profiles specific in terms of IgG subclasses, Fc-glycans and a fab-Peptide sequence.

Lundström SL, Fernandes-Cerqueira C, Ytterberg AJ, Ossipova E, Hensvold AH, Jakobsson PJ, Malmström V, Catrina AI, Klareskog L, Lundberg K, Zubarev RA.

PLoS One. 2014 Nov 26;9(11):e113924. doi: 10.1371/journal.pone.0113924. eCollection 2014.

PMID:
25426976
[PubMed - in process]
Free PMC Article
3.

Evaluation of urinary prostaglandin E2 metabolite as a biomarker in infants with fever due to viral infection.

Idborg H, Pawelzik SC, Perez-Manso M, Björk L, Hamrin J, Herlenius E, Jakobsson PJ.

Prostaglandins Leukot Essent Fatty Acids. 2014 Dec;91(6):269-75. doi: 10.1016/j.plefa.2014.09.006. Epub 2014 Sep 28.

PMID:
25305792
[PubMed - in process]
4.

Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint.

Ossipova E, Cerqueira CF, Reed E, Kharlamova N, Israelsson L, Holmdahl R, Nandakumar KS, Engström M, Harre U, Schett G, Catrina AI, Malmström V, Sommarin Y, Klareskog L, Jakobsson PJ, Lundberg K.

Arthritis Res Ther. 2014 Aug 12;16(4):R167. [Epub ahead of print]

PMID:
25112157
[PubMed - as supplied by publisher]
5.

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.

Ytterberg AJ, Joshua V, Reynisdottir G, Tarasova NK, Rutishauser D, Ossipova E, Haj Hensvold A, Eklund A, Sköld CM, Grunewald J, Malmström V, Jakobsson PJ, Rönnelid J, Padyukov L, Zubarev RA, Klareskog L, Catrina AI.

Ann Rheum Dis. 2014 May 9. doi: 10.1136/annrheumdis-2013-204912. [Epub ahead of print]

PMID:
24817415
[PubMed - as supplied by publisher]
6.

Persisting eicosanoid pathways in rheumatic diseases.

Korotkova M, Jakobsson PJ.

Nat Rev Rheumatol. 2014 Apr;10(4):229-41. doi: 10.1038/nrrheum.2014.1. Epub 2014 Feb 11. Review.

PMID:
24514915
[PubMed - indexed for MEDLINE]
7.

Differentially expressed proteins in malignant and benign adrenocortical tumors.

Kjellin H, Johansson H, Höög A, Lehtiö J, Jakobsson PJ, Kjellman M.

PLoS One. 2014 Feb 3;9(2):e87951. doi: 10.1371/journal.pone.0087951. eCollection 2014.

PMID:
24498411
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins.

Hensvold AH, Magnusson PK, Joshua V, Hansson M, Israelsson L, Ferreira R, Jakobsson PJ, Holmdahl R, Hammarström L, Malmström V, Askling J, Klareskog L, Catrina AI.

Ann Rheum Dis. 2015 Feb;74(2):375-80. doi: 10.1136/annrheumdis-2013-203947. Epub 2013 Nov 25.

PMID:
24276366
[PubMed - in process]
9.

Neutralization of anticitrullinated protein antibodies in rheumatoid arthritis - a way to go?

Cerqueira CF, Klareskog L, Jakobsson PJ.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):13-7. doi: 10.1111/bcpt.12157. Epub 2013 Nov 11. Review.

PMID:
24206219
[PubMed - indexed for MEDLINE]
10.

Characterization of microsomal prostaglandin E synthase 1 inhibitors.

Korotkova M, Jakobsson PJ.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):64-9. doi: 10.1111/bcpt.12162. Epub 2013 Nov 11. Review.

PMID:
24138533
[PubMed - indexed for MEDLINE]
11.

Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation.

Leclerc P, Idborg H, Spahiu L, Larsson C, Nekhotiaeva N, Wannberg J, Stenberg P, Korotkova M, Jakobsson PJ.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:26-34. doi: 10.1016/j.prostaglandins.2013.09.001. Epub 2013 Sep 14.

PMID:
24045148
[PubMed - indexed for MEDLINE]
12.

Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice.

Idborg H, Olsson P, Leclerc P, Raouf J, Jakobsson PJ, Korotkova M.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:18-25. doi: 10.1016/j.prostaglandins.2013.07.004. Epub 2013 Aug 2.

PMID:
23916744
[PubMed - indexed for MEDLINE]
13.

NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis.

Liu HQ, Zhang XY, Edfeldt K, Nijhuis MO, Idborg H, Bäck M, Roy J, Hedin U, Jakobsson PJ, Laman JD, de Kleijn DP, Pasterkamp G, Hansson GK, Yan ZQ.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2193-201. doi: 10.1161/ATVBAHA.113.301715. Epub 2013 Jul 18.

PMID:
23868940
[PubMed - indexed for MEDLINE]
Free Article
14.

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells.

Zirath H, Frenzel A, Oliynyk G, Segerström L, Westermark UK, Larsson K, Munksgaard Persson M, Hultenby K, Lehtiö J, Einvik C, Påhlman S, Kogner P, Jakobsson PJ, Henriksson MA.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10258-63. doi: 10.1073/pnas.1222404110. Epub 2013 Jun 3.

PMID:
23733953
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mass spectrometry-based proteomics identifies UPF1 as a critical gene expression regulator in MonoMac 6 cells.

Ochs MJ, Ossipova E, Oliynyk G, Steinhilber D, Suess B, Jakobsson PJ.

J Proteome Res. 2013 Jun 7;12(6):2622-9. doi: 10.1021/pr301193f. Epub 2013 May 24.

PMID:
23642263
[PubMed - indexed for MEDLINE]
16.

Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.

Howe LR, Subbaramaiah K, Kent CV, Zhou XK, Chang SH, Hla T, Jakobsson PJ, Hudis CA, Dannenberg AJ.

Prostaglandins Other Lipid Mediat. 2013 Oct;106:99-105. doi: 10.1016/j.prostaglandins.2013.04.002. Epub 2013 Apr 25.

PMID:
23624019
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Characterization of a new mPGES-1 inhibitor in rat models of inflammation.

Leclerc P, Pawelzik SC, Idborg H, Spahiu L, Larsson C, Stenberg P, Korotkova M, Jakobsson PJ.

Prostaglandins Other Lipid Mediat. 2013 Apr-May;102-103:1-12. doi: 10.1016/j.prostaglandins.2013.03.005. Epub 2013 Mar 23.

PMID:
23528231
[PubMed - indexed for MEDLINE]
18.

IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.

Leclerc P, Wähämaa H, Idborg H, Jakobsson PJ, Harris HE, Korotkova M.

Scand J Immunol. 2013 May;77(5):350-60. doi: 10.1111/sji.12041.

PMID:
23488692
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma.

Carlson LM, Rasmuson A, Idborg H, Segerström L, Jakobsson PJ, Sveinbjörnsson B, Kogner P.

Carcinogenesis. 2013 May;34(5):1081-8. doi: 10.1093/carcin/bgt009. Epub 2013 Jan 24.

PMID:
23349014
[PubMed - indexed for MEDLINE]
Free Article
20.

Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis.

Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Rönnelid J, Klareskog L, Rantapää-Dahlqvist S.

Arthritis Rheum. 2013 Apr;65(4):899-910. doi: 10.1002/art.37835.

PMID:
23310951
[PubMed - indexed for MEDLINE]
Free Article
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