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Items: 20


GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA.

Wilkinson-White L, Lester KL, Ripin N, Jacques DA, Mitchell Guss J, Matthews JM.

Protein Sci. 2015 Oct;24(10):1649-59. doi: 10.1002/pro.2760. Epub 2015 Aug 20.


The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket.

Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA.

Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1295-306. doi: 10.1107/S1399004715005817. Epub 2015 May 14.


Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC.

PLoS Pathog. 2014 Oct 30;10(10):e1004459. doi: 10.1371/journal.ppat.1004459. eCollection 2014 Oct.


The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface.

Kumar KK, Jacques DA, Guss JM, Gell DA.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):1032-7. doi: 10.1107/S2053230X14012175. Epub 2014 Jul 23.


Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens.

Tam JC, Jacques DA.

J Leukoc Biol. 2014 Aug;96(2):233-44. doi: 10.1189/jlb.4RI0214-090R. Epub 2014 Jun 4.


Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus.

Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA.

J Biol Chem. 2014 Mar 7;289(10):6728-38. doi: 10.1074/jbc.M113.545566. Epub 2014 Jan 14.


HIV-1 evades innate immune recognition through specific cofactor recruitment.

Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ.

Nature. 2013 Nov 21;503(7476):402-5. doi: 10.1038/nature12769. Epub 2013 Nov 6.


A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

Gadd MS, Jacques DA, Nisevic I, Craig VJ, Kwan AH, Guss JM, Matthews JM.

J Biol Chem. 2013 Jul 26;288(30):21924-35. doi: 10.1074/jbc.M113.478586. Epub 2013 Jun 9.


New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217.

Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP.

J Biol Chem. 2013 Apr 12;288(15):10616-27. doi: 10.1074/jbc.M112.441451. Epub 2013 Feb 22.


Crystallization and diffraction of an Isl1-Ldb1 complex.

Gadd MS, Jacques DA, Guss JM, Matthews JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1398-401. doi: 10.1107/S1744309112040031. Epub 2012 Oct 30.


Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution.

Jacques DA, Guss JM, Svergun DI, Trewhella J.

Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):620-6. doi: 10.1107/S0907444912012073. Epub 2012 May 17.


Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.

Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA.

J Biol Chem. 2011 Nov 4;286(44):38439-47. doi: 10.1074/jbc.M111.287300. Epub 2011 Sep 14.


The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase.

Jacques DA, Langley DB, Kuramitsu S, Yokoyama S, Trewhella J, Guss JM.

Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):105-11. doi: 10.1107/S0907444910051127. Epub 2011 Jan 8.


A novel structure of an antikinase and its inhibitor.

Jacques DA, Langley DB, Hynson RM, Whitten AE, Kwan A, Guss JM, Trewhella J.

J Mol Biol. 2011 Jan 7;405(1):214-26. doi: 10.1016/j.jmb.2010.10.047. Epub 2010 Nov 2.


1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis.

Hynson RM, Kwan AH, Jacques DA, Mackay JP, Trewhella J.

Biomol NMR Assign. 2010 Oct;4(2):167-9. doi: 10.1007/s12104-010-9237-6. Epub 2010 Jun 4.


Small-angle scattering for structural biology--expanding the frontier while avoiding the pitfalls.

Jacques DA, Trewhella J.

Protein Sci. 2010 Apr;19(4):642-57. doi: 10.1002/pro.351. Review.


Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state.

Jacques DA, Streamer M, Rowland SL, King GF, Guss JM, Trewhella J, Langley DB.

Acta Crystallogr D Biol Crystallogr. 2009 Jun;65(Pt 6):574-81. doi: 10.1107/S090744490901169X. Epub 2009 May 15.


Histidine kinase regulation by a cyclophilin-like inhibitor.

Jacques DA, Langley DB, Jeffries CM, Cunningham KA, Burkholder WF, Guss JM, Trewhella J.

J Mol Biol. 2008 Dec 12;384(2):422-35. doi: 10.1016/j.jmb.2008.09.017. Epub 2008 Sep 16.


The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition.

Whitten AE, Jacques DA, Hammouda B, Hanley T, King GF, Guss JM, Trewhella J, Langley DB.

J Mol Biol. 2007 Apr 27;368(2):407-20. Epub 2007 Feb 3.

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