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13 results

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Page 1
Safety and Efficacy of Axicabtagene Ciloleucel versus Standard of Care in Patients 65 Years of Age or Older with Relapsed/Refractory Large B-Cell Lymphoma.
Westin JR, Locke FL, Dickinson M, Ghobadi A, Elsawy M, van Meerten T, Miklos DB, Ulrickson ML, Perales MA, Farooq U, Wannesson L, Leslie L, Kersten MJ, Jacobson CA, Pagel JM, Wulf G, Johnston P, Rapoport AP, Du L, Vardhanabhuti S, Filosto S, Shah J, Snider JT, Cheng P, To C, Oluwole OO, Sureda A. Westin JR, et al. Clin Cancer Res. 2023 May 15;29(10):1894-1905. doi: 10.1158/1078-0432.CCR-22-3136. Clin Cancer Res. 2023. PMID: 36999993 Free PMC article. Clinical Trial.

In the quality-of-life analysis, the mean change in PRO scores from baseline at days 100 and 150 favored axi-cel for EORTC QLQ-C30 Global Health, Physical Functioning, and EQ-5D-5L visual analog scale (descriptive P < 0.05). CAR T-cell expansion and baseline serum infla

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In the quality-of-life analysis, the mean change in PRO scores from baseline at days 100 and 150 favored axi-cel for EORTC QLQ-C30 Global He …
Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.
Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, Jeong LS. Kim G, et al. J Med Chem. 2023 Sep 14;66(17):12249-12265. doi: 10.1021/acs.jmedchem.3c00806. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37603705
All tested compounds completely antagonized hA(2A)AR, including 5d with the highest affinity (K(i,A(2A)) = 7.7 0.5 nM). The hA(2A)AR-5d X-ray structure revealed that C8-heteroaromatic rings prevented receptor activation-associated conformational changes. ...Also, …
All tested compounds completely antagonized hA(2A)AR, including 5d with the highest affinity (K(i,A(2A)) = 7.7 0.5 nM). The hA(2A)AR- …
Validity and responsiveness of the euroqol as a measure of health-related quality of life in people enrolled in an AIDS clinical trial.
Wu AW, Jacobson KL, Frick KD, Clark R, Revicki DA, Freedberg KA, Scott-Lennox J, Feinberg J. Wu AW, et al. Qual Life Res. 2002 May;11(3):273-82. doi: 10.1023/a:1015240103565. Qual Life Res. 2002. PMID: 12074264

METHODS: Subjects with advanced HIV disease (CD4 < 100) were enrolled in a randomized trial for CMV prophylaxis (n = 990). The EQ-5D includes a weighted sum of five domains (EQ-5D Index) and a visual analog scale (EQ-VAS). ...Correlations between MOS-HIV PHS and

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METHODS: Subjects with advanced HIV disease (CD4 < 100) were enrolled in a randomized trial for CMV prophylaxis (n = 990). The EQ-5D

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Leukocyte proliferation and immune modulator production in patients with chronic kidney disease.
Mansouri L, Paulsson JM, Moshfegh A, Jacobson SH, Lundahl J. Mansouri L, et al. PLoS One. 2013 Aug 9;8(8):e73141. doi: 10.1371/journal.pone.0073141. eCollection 2013. PLoS One. 2013. PMID: 23951343 Free PMC article.
METHODS: Whole blood was drawn from healthy controls, patients with eGFR <20 ml/min/1.73 m(2) (Pre-dialysis, CKD stages 4 and 5) and hemodialysis patients (stage 5D). Peripheral cells were incubated for six days with pokeweed mitogen, concanavalin A, Staphylococcus ente …
METHODS: Whole blood was drawn from healthy controls, patients with eGFR <20 ml/min/1.73 m(2) (Pre-dialysis, CKD stages 4 and 5) and hemo …
The accommodative process in children with cerebral palsy: different strategies to obtain clear vision at short distance.
Pansell T, Hellgren K, Jacobson L, Brautaset R, Tedroff K. Pansell T, et al. Dev Med Child Neurol. 2014 Feb;56(2):171-7. doi: 10.1111/dmcn.12266. Epub 2013 Sep 4. Dev Med Child Neurol. 2014. PMID: 24000971 Free article.
RESULTS: The stimuli-response gain (input/output) was approximately 80% in typical children inducing a focusing error (0.2-0.5D) increasing with minus lens power. Children with CP accommodated significantly less (gain: ~30%; p<0.001), inducing a larger focusing error (1 …
RESULTS: The stimuli-response gain (input/output) was approximately 80% in typical children inducing a focusing error (0.2-0.5D) incr …
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.
Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS. Pal S, et al. Bioorg Med Chem. 2009 May 15;17(10):3733-8. doi: 10.1016/j.bmc.2009.03.034. Epub 2009 Mar 25. Bioorg Med Chem. 2009. PMID: 19375920 Free PMC article.
The 2-Cl series generally were better than the 2-H series in view of binding affinity and selectivity. Among compounds tested, compound 5d (X=Cl, R=3-bromobenzyl) showed the highest binding affinity (K(i)=13.0+/-6.9 nM) at the hA(3) AR with high selectivity (at least 88-fo …
The 2-Cl series generally were better than the 2-H series in view of binding affinity and selectivity. Among compounds tested, compound 5 …
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