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AVI-7288 for Marburg Virus in Nonhuman Primates and Humans.

Heald AE, Charleston JS, Iversen PL, Warren TK, Saoud JB, Al-Ibrahim M, Wells J, Warfield KL, Swenson DL, Welch LS, Sazani P, Wong M, Berry D, Kaye EM, Bavari S.

N Engl J Med. 2015 Jul 23;373(4):339-48. doi: 10.1056/NEJMoa1410345.


A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection.

Warren TK, Whitehouse CA, Wells J, Welch L, Heald AE, Charleston JS, Sazani P, Reid SP, Iversen PL, Bavari S.

MBio. 2015 Feb 10;6(1). pii: e02344-14. doi: 10.1128/mBio.02344-14.


Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.

Heald AE, Iversen PL, Saoud JB, Sazani P, Charleston JS, Axtelle T, Wong M, Smith WB, Vutikullird A, Kaye E.

Antimicrob Agents Chemother. 2014 Nov;58(11):6639-47. doi: 10.1128/AAC.03442-14. Epub 2014 Aug 25.


Induced IL-10 splice altering approach to antiviral drug discovery.

Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S.

Nucleic Acid Ther. 2014 Jun;24(3):179-85. doi: 10.1089/nat.2013.0457. Epub 2014 Mar 21.


Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.

Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI.

PLoS One. 2014 Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726. eCollection 2014.


Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice.

Mourich DV, Oda SK, Schnell FJ, Crumley SL, Hauck LL, Moentenich CA, Marshall NB, Hinrichs DJ, Iversen PL.

Nucleic Acid Ther. 2014 Apr;24(2):114-26. doi: 10.1089/nat.2013.0449. Epub 2014 Feb 4.


Gene-silencing antisense oligomers inhibit acinetobacter growth in vitro and in vivo.

Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE.

J Infect Dis. 2013 Nov 15;208(10):1553-60. doi: 10.1093/infdis/jit460. Epub 2013 Oct 14.


Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells.

Schnell FJ, Crumley SL, Mourich DV, Iversen PL.

Biores Open Access. 2013 Feb;2(1):61-6. doi: 10.1089/biores.2012.0276.


Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.

Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV.

PLoS Pathog. 2012 Dec;8(12):e1003073. doi: 10.1371/journal.ppat.1003073. Epub 2012 Dec 27.


Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.

Iversen PL, Warren TK, Wells JB, Garza NL, Mourich DV, Welch LS, Panchal RG, Bavari S.

Viruses. 2012 Nov 6;4(11):2806-30. doi: 10.3390/v4112806.


Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers.

Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL.

Antimicrob Agents Chemother. 2012 Dec;56(12):6147-53. doi: 10.1128/AAC.00850-12. Epub 2012 Sep 17.


Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S.

Nucleic Acid Ther. 2012 Oct;22(5):316-22. doi: 10.1089/nat.2012.0362. Epub 2012 Sep 14.


Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.

Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR.

Cancer Gene Ther. 2012 Jan;19(1):30-7. doi: 10.1038/cgt.2011.63. Epub 2011 Oct 14.


Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs.

Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S.

Oncogene. 2012 Feb 23;31(8):1024-33. doi: 10.1038/onc.2011.300. Epub 2011 Jul 18.


Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.

Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA.

Hum Mol Genet. 2011 Aug 15;20(16):3151-60. doi: 10.1093/hmg/ddr217. Epub 2011 May 16.


Advanced antisense therapies for postexposure protection against lethal filovirus infections.

Warren TK, Warfield KL, Wells J, Swenson DL, Donner KS, Van Tongeren SA, Garza NL, Dong L, Mourich DV, Crumley S, Nichols DK, Iversen PL, Bavari S.

Nat Med. 2010 Sep;16(9):991-4. doi: 10.1038/nm.2202. Epub 2010 Aug 22.


Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.

Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL.

J Infect Dis. 2010 Jun 15;201(12):1822-30. doi: 10.1086/652807.


Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.

Mellbye BL, Weller DD, Hassinger JN, Reeves MD, Lovejoy CE, Iversen PL, Geller BL.

J Antimicrob Chemother. 2010 Jan;65(1):98-106. doi: 10.1093/jac/dkp392. Epub .


Cellular uptake of neutral phosphorodiamidate morpholino oligomers.

Iversen PL, Aird KM, Wu R, Morse MM, Devi GR.

Curr Pharm Biotechnol. 2009 Sep;10(6):579-88. Epub 2009 Sep 1.


Inhibition of intracellular growth of Salmonella enterica serovar Typhimurium in tissue culture by antisense peptide-phosphorodiamidate morpholino oligomer.

Mitev GM, Mellbye BL, Iversen PL, Geller BL.

Antimicrob Agents Chemother. 2009 Sep;53(9):3700-4. doi: 10.1128/AAC.00099-09. Epub 2009 Jul 6.

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