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CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation.

Kaji T, Hijikata A, Ishige A, Kitami T, Watanabe T, Ohara O, Yanaka N, Okada M, Shimoda M, Taniguchi M, Takemori T.

Int Immunol. 2016 Jun;28(6):267-82. doi: 10.1093/intimm/dxv071. Epub 2015 Dec 29.


Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus.

Kaji T, Furukawa K, Ishige A, Toyokura I, Nomura M, Okada M, Takahashi Y, Shimoda M, Takemori T.

Int Immunol. 2013 Dec;25(12):683-95. doi: 10.1093/intimm/dxt030. Epub 2013 Sep 10.


Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, Nagashima T, Takahashi Y, Kurosaki T, Okada M, Ohara O, Rajewsky K, Takemori T.

J Exp Med. 2012 Oct 22;209(11):2079-97. doi: 10.1084/jem.20120127. Epub 2012 Oct 1.


A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development.

Yamamoto M, Yamaguchi R, Munakata K, Takashima K, Nishiyama M, Hioki K, Ohnishi Y, Nagasaki M, Imoto S, Miyano S, Ishige A, Watanabe K.

BMC Genomics. 2012 Jul 23;13:335. doi: 10.1186/1471-2164-13-335.


Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice.

Matsumoto M, Ishige A, Yazawa Y, Kondo M, Muramatsu K, Watanabe K.

PLoS One. 2012;7(2):e31700. doi: 10.1371/journal.pone.0031700. Epub 2012 Feb 22.


Type A aortic dissection with transient myocardial ischemia caused by intimal flap inverting into the left ventricle.

Ishige A, Tanaka H, Ueda T, Ninomiya M, Ohtsuka T.

J Echocardiogr. 2011 Sep;9(3):112-4. doi: 10.1007/s12574-010-0075-4. Epub 2010 Dec 28.


Administration of chinpi, a component of the herbal medicine ninjin-youei-to, reverses age-induced demyelination.

Sato N, Seiwa C, Uruse M, Yamamoto M, Tanaka K, Kawakita T, Komatsu Y, Yasukawa A, Takao M, Kudo C, Hasegawa A, Ishige A, Watanabe K, Asou H.

Evid Based Complement Alternat Med. 2011;2011:617438. doi: 10.1093/ecam/neq001. Epub 2011 Jun 5.


Maternal stress affects postnatal growth and the pituitary expression of prolactin in mouse offspring.

Gao P, Ishige A, Murakami Y, Nakata H, Oka J, Munakata K, Yamamoto M, Nishimura K, Watanabe K.

J Neurosci Res. 2011 Mar;89(3):329-40. doi: 10.1002/jnr.22550. Epub 2010 Dec 17. Erratum in: J Neurosci Res. 2011 Nov;89(11):1894.


Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment.

Nakata H, Watanabe K, Murakami Y, Gao P, Tsuiji K, Nishimura K, Plotnikoff GA, Kurihara N, Irie Y, Ishige A.

Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):433-41. doi: 10.1358/mf.2009.31.7.1407221.


Prolonged survival of fully mismatched cardiac allografts and generation of regulatory cells by Sairei-to, a Japanese herbal medicine.

Zhang Q, Iwami D, Aramaki O, Yakubo S, Nishimura K, Ishige A, Watanabe K, Matsuno K, Shirasugi N, Niimi M.

Transplantation. 2009 Jun 27;87(12):1787-91. doi: 10.1097/TP.0b013e3181a75917.


Intestinal flora induces the expression of Cyp3a in the mouse liver.

Toda T, Saito N, Ikarashi N, Ito K, Yamamoto M, Ishige A, Watanabe K, Sugiyama K.

Xenobiotica. 2009 Apr;39(4):323-34. doi: 10.1080/00498250802651984.


Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine.

Watanabe-Fukuda Y, Yamamoto M, Miura N, Fukutake M, Ishige A, Yamaguchi R, Nagasaki M, Saito A, Imoto S, Miyano S, Takeda J, Watanabe K.

J Gastroenterol. 2009;44(5):380-9. doi: 10.1007/s00535-009-0005-2. Epub 2009 Mar 25.


A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats.

Yamakawa J, Moriya J, Takahashi T, Ishige A, Motoo Y, Yoshizaki F, Kanda T.

Evid Based Complement Alternat Med. 2010 Mar;7(1):87-95. doi: 10.1093/ecam/nem153. Epub 2007 Nov 14.


A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1).

Yamamoto M, Yoshimura K, Kitada M, Nakahara J, Seiwa C, Ueki T, Shimoda Y, Ishige A, Watanabe K, Asou H.

J Neurosci Res. 2009 Feb;87(2):503-13. doi: 10.1002/jnr.21853.


Identification of activated transcription factors from microarray gene expression data of Kampo medicine-treated mice.

Yamaguchi R, Yamamoto M, Imoto S, Nagasaki M, Yoshida R, Tsuiji K, Ishige A, Asou H, Watanabe K, Miyano S.

Genome Inform. 2007;18:119-29.


Importance of the interferon-alpha system in murine large intestine indicated by microarray analysis of commensal bacteria-induced immunological changes.

Munakata K, Yamamoto M, Anjiki N, Nishiyama M, Imamura S, Iizuka S, Takashima K, Ishige A, Hioki K, Ohnishi Y, Watanabe K.

BMC Genomics. 2008 Apr 26;9:192. doi: 10.1186/1471-2164-9-192.


[Angina pectoris in patients who underwent stent implantations for severe atherosclerotic coronary lesions 16 years after heart transplantation].

Yamada A, Ishii Y, Kakizawa Y, Ishige A, Ueno H, Omichi C, Tanaka T, Nagashima H, Kanmatsuse K, Endo M.

Kyobu Geka. 2007 Oct;60(11):969-73. Japanese.


Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes.

Ikeda Y, Takei H, Matsumoto C, Mase A, Yamamoto M, Takeda S, Ishige A, Watanabe K.

Arch Dermatol Res. 2007 Sep;299(7):345-51. Epub 2007 Jul 21.


Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse.

Kato M, Ishige A, Anjiki N, Yamamoto M, Irie Y, Taniyama M, Kibe R, Oka J, Benno Y, Watanabe K.

World J Gastroenterol. 2007 Apr 28;13(16):2289-97.


Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice.

Sakai R, Irie Y, Murata T, Ishige A, Anjiki N, Watanabe K.

Phytother Res. 2007 Sep;21(9):868-73.

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