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Items: 1 to 20 of 39


Testing an aflatoxin B1 gene signature in rat archival tissues.

Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR.

Chem Res Toxicol. 2012 May 21;25(5):1132-44. doi: 10.1021/tx3000945. Epub 2012 May 4.


Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

Zheng C, Voutetakis A, Goldstein B, Afione S, Rivera VM, Clackson T, Wenk ML, Boyle M, Nyska A, Chiorini JA, Vallant M, Irwin RD, Baum BJ.

Toxicol Sci. 2011 Sep;123(1):247-55. doi: 10.1093/toxsci/kfr144. Epub 2011 May 30.


Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning.

Auerbach SS, Shah RR, Mav D, Smith CS, Walker NJ, Vallant MK, Boorman GA, Irwin RD.

Toxicol Appl Pharmacol. 2010 Mar 15;243(3):300-14. doi: 10.1016/j.taap.2009.11.021. Epub 2009 Dec 11.


Gene set enrichment analysis for non-monotone association and multiple experimental categories.

Lin R, Dai S, Irwin RD, Heinloth AN, Boorman GA, Li L.

BMC Bioinformatics. 2008 Nov 14;9:481. doi: 10.1186/1471-2105-9-481.


A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.

Auerbach SS, Mahler J, Travlos GS, Irwin RD.

Toxicology. 2008 Nov 20;253(1-3):79-88. doi: 10.1016/j.tox.2008.08.014. Epub 2008 Sep 4.


Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.


Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.

Voutetakis A, Zheng C, Wang J, Goldsmith CM, Afione S, Chiorini JA, Wenk ML, Vallant M, Irwin RD, Baum BJ.

Hum Gene Ther. 2007 Nov;18(11):1109-18.


Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age.

Mori K, Blackshear PE, Lobenhofer EK, Parker JS, Orzech DP, Roycroft JH, Walker KL, Johnson KA, Marsh TA, Irwin RD, Boorman GA.

Toxicol Pathol. 2007 Feb;35(2):242-51.


Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.

Zheng C, Goldsmith CM, Mineshiba F, Chiorini JA, Kerr A, Wenk ML, Vallant M, Irwin RD, Baum BJ.

Hum Gene Ther. 2006 Nov;17(11):1122-33.


Gene interaction network analysis suggests differences between high and low doses of acetaminophen.

Toyoshiba H, Sone H, Yamanaka T, Parham FM, Irwin RD, Boorman GA, Portier CJ.

Toxicol Appl Pharmacol. 2006 Sep 15;215(3):306-16. Epub 2006 May 15.


Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland.

Zheng C, Voutetakis A, Kok MR, Goldsmith CM, Smith GB, Elmore S, Nyska A, Vallant M, Irwin RD, Baum BJ.

Oral Dis. 2006 Mar;12(2):137-44.


A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen.

Irwin RD.

J Appl Toxicol. 2006 Jan-Feb;26(1):72-80. Review.


Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments.

Boorman GA, Blackshear PE, Parker JS, Lobenhofer EK, Malarkey DE, Vallant MK, Gerken DK, Irwin RD.

Toxicol Sci. 2005 Jul;86(1):185-93. Epub 2005 Apr 6.


Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen.

Irwin RD, Parker JS, Lobenhofer EK, Burka LT, Blackshear PE, Vallant MK, Lebetkin EH, Gerken DF, Boorman GA.

Toxicol Pathol. 2005;33(1):111-7.


Variation in the hepatic gene expression in individual male Fischer rats.

Boorman GA, Irwin RD, Vallant MK, Gerken DK, Lobenhofer EK, Hejtmancik MR, Hurban P, Brys AM, Travlos GS, Parker JS, Portier CJ.

Toxicol Pathol. 2005;33(1):102-10.


Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data.

Irwin RD, Boorman GA, Cunningham ML, Heinloth AN, Malarkey DE, Paules RS.

Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:72-83. Review.


Gene expression profiling of rat livers reveals indicators of potential adverse effects.

Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS.

Toxicol Sci. 2004 Jul;80(1):193-202. Epub 2004 Apr 14.


Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.

Hayashi SM, Ton TV, Hong HH, Irwin RD, Haseman JK, Devereux TR, Sills RC.

Chem Biol Interact. 2003 Dec 15;146(3):251-61.

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