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Results: 1 to 20 of 159

1.

Engineering bacterial transcription regulation to create a synthetic in vitro two-hybrid system for protein interaction assays.

Zhou Y, Asahara H, Schneider N, Dranchak P, Inglese J, Chong S.

J Am Chem Soc. 2014 Sep 4. [Epub ahead of print]

PMID:
25188838
[PubMed - as supplied by publisher]
2.

Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-Tooth disease.

Inglese J, Dranchak P, Moran JJ, Jang SW, Srinivasan R, Santiago Y, Zhang L, Guha R, Martinez N, Macarthur R, Cost GJ, Svaren JP.

ACS Chem Biol. 2014 Sep 4. [Epub ahead of print]

PMID:
25188731
[PubMed - as supplied by publisher]
3.

Identification of Small Molecule Modulators of Gene Transcription with Anti-Cancer Activity.

Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED.

ACS Chem Biol. 2014 Sep 4. [Epub ahead of print]

PMID:
25188650
[PubMed - as supplied by publisher]
4.

The increasing urgency for standards in basic biologic research.

Freedman LP, Inglese J.

Cancer Res. 2014 Aug 1;74(15):4024-9. doi: 10.1158/0008-5472.CAN-14-0925. Epub 2014 Jul 17.

PMID:
25035389
[PubMed - in process]
5.

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT.

PLoS One. 2014 Mar 25;9(3):e90766. doi: 10.1371/journal.pone.0090766. eCollection 2014.

PMID:
24667240
[PubMed - in process]
Free PMC Article
6.

A high content screening approach to identify molecules neuroprotective for photoreceptor cells.

Fuller JA, Shaw GC, Bonnet-Wersinger D, Hansen BS, Berlinicke CA, Inglese J, Zack DJ.

Adv Exp Med Biol. 2014;801:773-81. doi: 10.1007/978-1-4614-3209-8_97.

PMID:
24664770
[PubMed - indexed for MEDLINE]
7.

Chemical genomics for studying parasite gene function and interaction.

Li J, Yuan J, Cheng KC, Inglese J, Su XZ.

Trends Parasitol. 2013 Dec;29(12):603-11. doi: 10.1016/j.pt.2013.10.005. Epub 2013 Nov 9. Review.

PMID:
24215777
[PubMed - indexed for MEDLINE]
8.

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR.

ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

PMID:
24040486
[PubMed]
Free PMC Article
9.

Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.

Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL; VRC 312 Study Team.

Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8.

PMID:
23929949
[PubMed - indexed for MEDLINE]
10.

Innovation in academic chemical screening: filling the gaps in chemical biology.

Hasson SA, Inglese J.

Curr Opin Chem Biol. 2013 Jun;17(3):329-38. doi: 10.1016/j.cbpa.2013.04.018. Epub 2013 May 14. Review.

PMID:
23683346
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.

Dranchak P, MacArthur R, Guha R, Zuercher WJ, Drewry DH, Auld DS, Inglese J.

PLoS One. 2013;8(3):e57888. doi: 10.1371/journal.pone.0057888. Epub 2013 Mar 7.

PMID:
23505445
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50. doi: 10.1073/pnas.1211284110. Epub 2013 Feb 19.

PMID:
23431148
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ.

Medchemcomm. 2012 Dec;3(12):1505-1511.

PMID:
23205265
[PubMed]
Free PMC Article
14.

Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT.

Maret D, Telmon N, Peters OA, Lepage B, Treil J, Inglèse JM, Peyre A, Kahn JL, Sixou M.

Dentomaxillofac Radiol. 2012 Dec;41(8):649-55. doi: 10.1259/dmf/81804525.

PMID:
23166362
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A coincidence reporter-gene system for high-throughput screening.

Cheng KC, Inglese J.

Nat Methods. 2012 Oct;9(10):937. doi: 10.1038/nmeth.2170. No abstract available.

PMID:
23018994
[PubMed - indexed for MEDLINE]
16.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

PMID:
22922757
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J.

Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015.

PMID:
22921073
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies.

Hughes M, Inglese J, Kurtz A, Andalibi A, Patton L, Austin C, Baltezor M, Beckloff M, Sittampalam S, Weingarten M, Weir S.

In: Sittampalam GS, Gal-Edd N, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Lemmon V, Li Z, McGee J, McManus O, Minor L, Napper A, Riss T, Trask OJ, Weidner J, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 01 [updated 2012 Oct 01].

PMID:
22553881
[PubMed]
Books & Documents
19.

Identification of drug modulators targeting gene-dosage disease CMT1A.

Jang SW, Lopez-Anido C, MacArthur R, Svaren J, Inglese J.

ACS Chem Biol. 2012 Jul 20;7(7):1205-13. doi: 10.1021/cb300048d. Epub 2012 May 2.

PMID:
22530759
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.

Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W.

Medchemcomm. 2011 Oct;2(10):1016-1020.

PMID:
22408719
[PubMed]
Free PMC Article

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