Format

Send to:

Choose Destination

See 1 citation found using an alternative search:

See comment in PubMed Commons below
AIDS. 2012 Aug 24;26(13):1645-52.

Increased regression and decreased incidence of human papillomavirus-related cervical lesions among HIV-infected women on HAART.

Author information

  • 1Department of Emergency Medicine, University of Rochester, Rochester, NY 14642, USA. david_adler@urmc.rochester.edu

Abstract

OBJECTIVE:

To determine the impact of HAART on incidence, regression, and progression of cytopathological abnormalities in HIV-infected women.

DESIGN:

Prospective cohort.

METHODS:

HIV-infected women (N=1123) from Soweto, South Africa underwent serial cervical smears that were analyzed and reported using the Bethesda System. The results of HAART and non-HAART users were compared using two statistical approaches: a survival analysis assessing risk of incident smear abnormality among women with baseline normal smear results; and analysis with marginal models assessing for an association between HAART use and likelihood of regression/progression in consecutive smears.

RESULTS:

After multivariate survival analysis, women using HAART with a normal baseline smear were 38% less likely to have an incident smear abnormality during follow-up than nonusers [confidence interval (CI) 0.42-0.91; P=0.01]. Multivariate marginal models analysis identified a significantly increased likelihood (odds ratio 2.61; CI 1.75-3.89; P<0.0001) of regression of cervical lesions among women on HAART.

CONCLUSION:

Our large prospective cohort study adds significant weight to the side of the balance of clinical research supporting the positive impact of HAART on the natural history of human papillomavirus-related cervical disease in HIV-infected women.

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

PMID:
22555167
[PubMed - indexed for MEDLINE]
PMCID:
PMC3709565
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk