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Results: 1 to 20 of 202

1.

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment.

Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

PLoS One. 2015 Feb 23;10(2):e0118463. doi: 10.1371/journal.pone.0118463. eCollection 2015.

2.

Age-associated white matter lesions: the MRC Cognitive Function and Ageing Study.

Wharton SB, Simpson JE, Brayne C, Ince PG.

Brain Pathol. 2015 Jan;25(1):35-43. doi: 10.1111/bpa.12219.

PMID:
25521175
3.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the MRC-CFAS ageing brain cohort.

Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2014 Dec 1. doi: 10.1111/nan.12202. [Epub ahead of print]

PMID:
25443110
4.

Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology.

Beer AM, Cooper-Knock J, Higginbottom A, Highley JR, Wharton SB, Ince PG, Milano A, Jones AA, Al-Chalabi A, Kirby J, Shaw PJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec 1:1-3. [Epub ahead of print] No abstract available.

PMID:
25436637
5.

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm. 2014 Nov 25. [Epub ahead of print] No abstract available.

PMID:
25418279
6.

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.

Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study.

Brain Pathol. 2014 Oct 14. doi: 10.1111/bpa.12216. [Epub ahead of print]

7.

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm. 2014 Sep 20. [Epub ahead of print]

PMID:
25239189
8.

TDP-43 pathology in the population: prevalence and associations with dementia and age.

Keage HA, Hunter S, Matthews FE, Ince PG, Hodges J, Hokkanen SR, Highley JR, Dening T, Brayne C.

J Alzheimers Dis. 2014;42(2):641-50. doi: 10.3233/JAD-132351.

PMID:
25170584
9.

TDP-43 in the Population: Prevalence and Associations with Dementia and Age.

Keage HA, Hunter S, Matthews FE, Ince PG, Hodges J, Hokkanen S, Highley JR, Dening T, Brayne C.

J Alzheimers Dis. 2014 Jun 13. [Epub ahead of print]

PMID:
24927703
10.

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Cooper-Knock J, Walsh MJ, Higginbottom A, Robin Highley J, Dickman MJ, Edbauer D, Ince PG, Wharton SB, Wilson SA, Kirby J, Hautbergue GM, Shaw PJ.

Brain. 2014 Jul;137(Pt 7):2040-51. doi: 10.1093/brain/awu120. Epub 2014 May 27.

11.

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.

Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB; MRC Cognitive Function and Ageing Study.

Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. doi: 10.1111/nan.12156.

PMID:
24861546
12.

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.

Highley JR, Kirby J, Jansweijer JA, Webb PS, Hewamadduma CA, Heath PR, Higginbottom A, Raman R, Ferraiuolo L, Cooper-Knock J, McDermott CJ, Wharton SB, Shaw PJ, Ince PG.

Neuropathol Appl Neurobiol. 2014 Oct;40(6):670-85. doi: 10.1111/nan.12148.

PMID:
24750229
13.

PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.

Yang DJ, Wang XL, Ismail A, Ashman CJ, Valori CF, Wang G, Gao S, Higginbottom A, Ince PG, Azzouz M, Xu J, Shaw PJ, Ning K.

Cell Death Dis. 2014 Feb 27;5:e1096. doi: 10.1038/cddis.2014.55.

14.

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, Alafuzoff I, Antonell A, Bogdanovic N, Brooks W, Cairns NJ, Cooper-Knock J, Cotman C, Cras P, Cruts M, De Deyn PP, DeCarli C, Dobson-Stone C, Engelborghs S, Fox N, Galasko D, Gearing M, Gijselinck I, Grafman J, Hartikainen P, Hatanpaa KJ, Highley JR, Hodges J, Hulette C, Ince PG, Jin LW, Kirby J, Kofler J, Kril J, Kwok JB, Levey A, Lieberman A, Llado A, Martin JJ, Masliah E, McDermott CJ, McKee A, McLean C, Mead S, Miller CA, Miller J, Munoz DG, Murrell J, Paulson H, Piguet O, Rossor M, Sanchez-Valle R, Sano M, Schneider J, Silbert LC, Spina S, van der Zee J, Van Langenhove T, Warren J, Wharton SB, White CL 3rd, Woltjer RL, Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS.

Acta Neuropathol. 2014 Mar;127(3):407-18. doi: 10.1007/s00401-013-1239-x. Epub 2014 Jan 19.

15.

C9ORF72 expansions, parkinsonism, and Parkinson disease: a clinicopathologic study.

Cooper-Knock J, Frolov A, Highley JR, Charlesworth G, Kirby J, Milano A, Hartley J, Ince PG, McDermott CJ, Lashley T, Revesz T, Shaw PJ, Wood NW, Bandmann O.

Neurology. 2013 Aug 27;81(9):808-11. doi: 10.1212/WNL.0b013e3182a2cc38. Epub 2013 Jul 24.

16.

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

Richardson K, Allen SP, Mortiboys H, Grierson AJ, Wharton SB, Ince PG, Shaw PJ, Heath PR.

PLoS One. 2013 Jun 28;8(6):e68256. doi: 10.1371/journal.pone.0068256. Print 2013.

17.

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.

Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study.

Neuropathol Appl Neurobiol. 2014 Apr;40(3):258-69. doi: 10.1111/nan.12062.

18.

Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study.

Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I.

J Neuropathol Exp Neurol. 2013 Jun;72(6):452-61. doi: 10.1097/NEN.0b013e318292492a.

PMID:
23656988
19.

Focal cortical dysplasia mimicking neoplasia.

Bahl A, Romanowski CA, Ince PG, McKevitt FM, Jellinek DA.

Pract Neurol. 2013 Oct;13(5):343-5. doi: 10.1136/practneurol-2012-000317. Epub 2013 Mar 15. No abstract available.

PMID:
23504031
20.

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.

Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2013 Dec;39(7):788-99. doi: 10.1111/nan.12033.

PMID:
23421725
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