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Items: 1 to 20 of 214

1.

Microglial immunophenotype in dementia with Alzheimer's pathology.

Minett T, Classey J, Matthews FE, Fahrenhold M, Taga M, Brayne C, Ince PG, Nicoll JA, Boche D; MRC CFAS.

J Neuroinflammation. 2016 Jun 2;13(1):135. doi: 10.1186/s12974-016-0601-z.

2.

Expression microdissection isolation of enriched cell populations from archival brain tissue.

Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG, Heath PR.

J Neurosci Methods. 2016 Aug 1;268:125-30. doi: 10.1016/j.jneumeth.2016.05.007. Epub 2016 May 10.

PMID:
27178137
3.

Metaflammasome components in the human brain: a role in dementia with alzheimer's pathology?

Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll JA, Hugon J, Boche D; MRC CFAS.

Brain Pathol. 2016 Apr 22. doi: 10.1111/bpa.12388. [Epub ahead of print]

PMID:
27106634
4.

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study.

Wharton SB, Minett T, Drew D, Forster G, Matthews F, Brayne C, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group.

Acta Neuropathol Commun. 2016 Feb 8;4:11. doi: 10.1186/s40478-016-0275-x.

5.

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE; MRC Cognitive Function Ageing Neuropathology Study Group.

Neurosci Lett. 2015 Nov 16;609:11-7. doi: 10.1016/j.neulet.2015.10.001. Epub 2015 Oct 8.

6.

Genome-wide association study of neocortical Lewy-related pathology.

Peuralinna T, Myllykangas L, Oinas M, Nalls MA, Keage HA, Isoviita VM, Valori M, Polvikoski T, Paetau A, Sulkava R, Ince PG, Zaccai J, Brayne C, Traynor BJ, Hardy J, Singleton AB, Tienari PJ.

Ann Clin Transl Neurol. 2015 Sep;2(9):920-31. doi: 10.1002/acn3.231. Epub 2015 Aug 18.

7.

Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS.

Bury JJ, Highley JR, Cooper-Knock J, Goodall EF, Higginbottom A, McDermott CJ, Ince PG, Shaw PJ, Kirby J.

Neuropathology. 2016 Apr;36(2):125-34. doi: 10.1111/neup.12240. Epub 2015 Aug 24.

PMID:
26303227
8.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.

Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG, Wharton SB.

Mol Brain. 2015 Aug 22;8:51. doi: 10.1186/s13041-015-0138-6.

9.

Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions.

Highley JR, Lorente Pons A, Cooper-Knock J, Wharton SB, Ince PG, Shaw PJ, Wood J, Kirby J.

Neuropathol Appl Neurobiol. 2016 Jun;42(4):377-89. doi: 10.1111/nan.12254. Epub 2015 Jul 7.

PMID:
26095883
10.

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):167-79. doi: 10.1111/nan.12252. Epub 2015 Jul 7.

PMID:
26095650
11.

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.

Cooper-Knock J, Higginbottom A, Stopford MJ, Highley JR, Ince PG, Wharton SB, Pickering-Brown S, Kirby J, Hautbergue GM, Shaw PJ.

Acta Neuropathol. 2015 Jul;130(1):63-75. doi: 10.1007/s00401-015-1429-9. Epub 2015 May 6.

12.

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly.

Zaccai J, Brayne C, Matthews FE, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study.

Alzheimers Res Ther. 2015 Apr 13;7(1):19. doi: 10.1186/s13195-015-0101-x. eCollection 2015.

13.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

PLoS One. 2015 Feb 23;10(2):e0118463. doi: 10.1371/journal.pone.0118463. eCollection 2015.

14.

Age-associated white matter lesions: the MRC Cognitive Function and Ageing Study.

Wharton SB, Simpson JE, Brayne C, Ince PG.

Brain Pathol. 2015 Jan;25(1):35-43. doi: 10.1111/bpa.12219.

PMID:
25521175
15.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2015 Jun;41(4):483-96. doi: 10.1111/nan.12202. Epub 2015 Apr 23.

16.

Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology.

Beer AM, Cooper-Knock J, Higginbottom A, Highley JR, Wharton SB, Ince PG, Milano A, Jones AA, Al-Chalabi A, Kirby J, Shaw PJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2015 Jun;16(3-4):249-51. doi: 10.3109/21678421.2014.977296. Epub 2014 Dec 1. No abstract available.

PMID:
25436637
17.

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm (Vienna). 2015 Jul;122(7):973-4. doi: 10.1007/s00702-014-1337-5. No abstract available.

PMID:
25418279
18.

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.

Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study.

Brain Pathol. 2015 Sep;25(5):565-74. doi: 10.1111/bpa.12216. Epub 2014 Nov 20.

19.

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm (Vienna). 2015 Jul;122(7):957-72. doi: 10.1007/s00702-014-1304-1. Epub 2014 Sep 20. Erratum in: J Neural Transm (Vienna). 2015 Jul;122(7):973-4.

PMID:
25239189
20.

TDP-43 pathology in the population: prevalence and associations with dementia and age.

Keage HA, Hunter S, Matthews FE, Ince PG, Hodges J, Hokkanen SR, Highley JR, Dening T, Brayne C.

J Alzheimers Dis. 2014;42(2):641-50. doi: 10.3233/JAD-132351.

PMID:
25170584
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