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Year Number of Results
1965 1
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1989 1
1990 1
1991 2
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1994 3
1996 2
1998 4
1999 3
2000 2
2001 2
2002 2
2004 3
2005 2
2006 4
2007 2
2008 1
2009 1
2010 3
2011 4
2012 3
2013 5
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143 results

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Page 1
Imperialine and Verticinone from Bulbs of Fritillaria wabuensis Inhibit Pro-inflammatory Mediators in LPS-stimulated RAW 264.7 Macrophages.
Wu K, Mo C, Xiao H, Jiang Y, Ye B, Wang S. Wu K, et al. Planta Med. 2015 Jul;81(10):821-9. doi: 10.1055/s-0035-1546170. Epub 2015 Jul 1. Planta Med. 2015. PMID: 26132855
The effect of verticinone and imperialine on the activation of nuclear factor-kappaB was also evaluated. ...According to the results of our researches, verticinone and imperialine may present great potentials to be developed as therapeutics for inflammatory diseases …
The effect of verticinone and imperialine on the activation of nuclear factor-kappaB was also evaluated. ...According to the results …
Intestinal absorption characteristics of imperialine: in vitro and in situ assessments.
Lin Q, Ling LQ, Guo L, Gong T, Sun X, Zhang ZR. Lin Q, et al. Acta Pharmacol Sin. 2015 Jul;36(7):863-73. doi: 10.1038/aps.2015.27. Epub 2015 Jun 8. Acta Pharmacol Sin. 2015. PMID: 26051111 Free PMC article.
METHODS: Caco-2 cells were used to examine uptake and transport of imperialine in vitro, and a rat in situ intestinal perfusion model was used to characterize the absorption of imperialine. The amount of imperialine in the samples was quantified using LC-MS/M …
METHODS: Caco-2 cells were used to examine uptake and transport of imperialine in vitro, and a rat in situ intestinal perfusion model …
Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine.
Lin Q, Qu M, Zhou B, Patra HK, Sun Z, Luo Q, Yang W, Wu Y, Zhang Y, Li L, Deng L, Wang L, Gong T, He Q, Zhang L, Sun X, Zhang Z. Lin Q, et al. J Control Release. 2019 Oct;311-312:104-116. doi: 10.1016/j.jconrel.2019.08.037. Epub 2019 Sep 1. J Control Release. 2019. PMID: 31484040
Here, we report a highly biocompatible tumor cell-targeting delivery systems utilizing exosome-like vesicles (ELVs) that delivers a low-toxicity anti-cancer agent imperialine against non-small cell lung cancer (NSCLC). First, we introduced a novel micelle-aided method to e …
Here, we report a highly biocompatible tumor cell-targeting delivery systems utilizing exosome-like vesicles (ELVs) that delivers a low-toxi …
Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer.
Lin Q, Qu M, Patra HK, He S, Wang L, Hu X, Xiao L, Fu Y, Gong T, He Q, Zhang L, Sun X, Zhang Z. Lin Q, et al. J Ethnopharmacol. 2020 Jan 30;247:112283. doi: 10.1016/j.jep.2019.112283. Epub 2019 Oct 9. J Ethnopharmacol. 2020. PMID: 31605736
RESULTS: The results showed that imperialine could suppress both NSCLC tumor and associated inflammation through an inflammation-cancer feedback loop in which NF-kappaB activity was dramatically inhibited by imperialine. ...This work has identified imperialine …
RESULTS: The results showed that imperialine could suppress both NSCLC tumor and associated inflammation through an inflammation-canc …
The Isosteroid Alkaloid Imperialine from Bulbs of Fritillaria cirrhosa Mitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model.
Wang D, Du Q, Li H, Wang S. Wang D, et al. Mediators Inflamm. 2016;2016:4192483. doi: 10.1155/2016/4192483. Epub 2016 Jul 20. Mediators Inflamm. 2016. PMID: 27524867 Free PMC article.
Steroidal alkaloids are the major biological active constituents in BFC, whereby imperialine is one of the important steroidal alkaloids. So far, there are no studies reporting the effect of imperialine on COPD. In this study, we investigated the effect of imperi …
Steroidal alkaloids are the major biological active constituents in BFC, whereby imperialine is one of the important steroidal alkalo …
Chemical profiling of Fritillariae thunbergii Miq prepared by different processing methods reveals two new quality markers: Zhebeininoside and imperialine-3-beta-D-glucoside.
Shi YH, Huang QW, Zhu SM, Zhou YM, Zhang LJ, Huang WK, Shao JJ, Zhou JL, Zhang WT. Shi YH, et al. J Ethnopharmacol. 2022 Jan 30;283:114670. doi: 10.1016/j.jep.2021.114670. Epub 2021 Oct 12. J Ethnopharmacol. 2022. PMID: 34653522
RESULTS: we have previously found two new steroidal alkaloids: zhebeininoside and imperialine-3-beta-D-glucoside from the different processing methods of FTM, which is the difference between the different processing methods of FTM, mainly on the steroidal alkaloids. The ac …
RESULTS: we have previously found two new steroidal alkaloids: zhebeininoside and imperialine-3-beta-D-glucoside from the different p …
A (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)-dispersed sustained-release tablet for imperialine to simultaneously prolong the drug release and improve the oral bioavailability.
Lin Q, Fu Y, Li J, Qu M, Deng L, Gong T, Zhang Z. Lin Q, et al. Eur J Pharm Sci. 2015 Nov 15;79:44-52. doi: 10.1016/j.ejps.2015.08.018. Epub 2015 Sep 5. Eur J Pharm Sci. 2015. PMID: 26349052
Imperialine, extracted from Bulbus Fritillariae Cirrhosae, is an efficient antitussive and expectorant medicine. However, its short half-life and stomach degradation limited imperialine from further clinical use. The current study was conducted to develop a sustaine …
Imperialine, extracted from Bulbus Fritillariae Cirrhosae, is an efficient antitussive and expectorant medicine. However, its short h …
Fusarium redolens 6WBY3, an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis, produces peimisine and imperialine-3beta-D-glucoside.
Pan BF, Su X, Hu B, Yang N, Chen Q, Wu W. Pan BF, et al. Fitoterapia. 2015 Jun;103:213-21. doi: 10.1016/j.fitote.2015.04.006. Epub 2015 Apr 11. Fitoterapia. 2015. PMID: 25869849
Using color reaction analysis, high performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD), and mass spectrometry (MS), it was demonstrated that F. redolens 6WBY3 could produce peimisine and imperialine-3beta-D-glucoside, similar to its h …
Using color reaction analysis, high performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD), and mass spec …
143 results