J Surg Oncol. 2011 May 1;103(6):518-30. doi: 10.1002/jso.21815.

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients.

Leong SP, Zuber M, Ferris RL, Kitagawa Y, Cabanas R, Levenback C, Faries M, Saha S.

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Center for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical and Research Institute, San Francisco, California 94115, USA. leongsx@cpmcri.org

Abstract

The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

PMID:: 21480244; [PubMed - indexed for MEDLINE]

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Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical ...
Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients.
J Surg Oncol. 2011 May 1 ;103(6):518-30. doi: 10.1002/jso.21815.

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